IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

DE FRANCESCO, RAFFAELE
 Distribuzione geografica
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Continente #
EU - Europa 6.842
NA - Nord America 5.404
AS - Asia 3.910
SA - Sud America 494
AF - Africa 105
OC - Oceania 54
Continente sconosciuto - Info sul continente non disponibili 3
Totale 16.812
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Nazione #
US - Stati Uniti d'America 5.215
DE - Germania 2.846
CN - Cina 1.448
GB - Regno Unito 1.346
SG - Singapore 1.167
IT - Italia 1.040
SE - Svezia 449
HK - Hong Kong 412
BR - Brasile 406
RU - Federazione Russa 310
IN - India 231
IE - Irlanda 165
CA - Canada 152
FR - Francia 145
NL - Olanda 143
ID - Indonesia 128
VN - Vietnam 120
KR - Corea 97
DK - Danimarca 77
FI - Finlandia 70
JP - Giappone 68
AU - Australia 46
TR - Turchia 45
AT - Austria 43
CH - Svizzera 32
UA - Ucraina 31
ES - Italia 28
AR - Argentina 27
BD - Bangladesh 27
BE - Belgio 25
IQ - Iraq 24
PH - Filippine 24
PL - Polonia 24
CI - Costa d'Avorio 23
MX - Messico 23
ZA - Sudafrica 23
TW - Taiwan 19
EC - Ecuador 15
CO - Colombia 12
EG - Egitto 12
AE - Emirati Arabi Uniti 11
PK - Pakistan 11
CL - Cile 10
CZ - Repubblica Ceca 10
MA - Marocco 10
SA - Arabia Saudita 10
GR - Grecia 9
KE - Kenya 9
RO - Romania 9
TH - Thailandia 9
MY - Malesia 8
NZ - Nuova Zelanda 8
UZ - Uzbekistan 8
PE - Perù 7
ET - Etiopia 6
IL - Israele 6
PT - Portogallo 6
SC - Seychelles 6
UY - Uruguay 6
IR - Iran 5
JO - Giordania 5
PA - Panama 5
VE - Venezuela 5
DZ - Algeria 4
KZ - Kazakistan 4
NO - Norvegia 4
NP - Nepal 4
OM - Oman 4
AZ - Azerbaigian 3
BG - Bulgaria 3
EU - Europa 3
HU - Ungheria 3
LB - Libano 3
LV - Lettonia 3
MK - Macedonia 3
RS - Serbia 3
SK - Slovacchia (Repubblica Slovacca) 3
TN - Tunisia 3
AL - Albania 2
BH - Bahrain 2
BO - Bolivia 2
BY - Bielorussia 2
DO - Repubblica Dominicana 2
KG - Kirghizistan 2
LT - Lituania 2
MD - Moldavia 2
NG - Nigeria 2
PY - Paraguay 2
UG - Uganda 2
A1 - Anonimo 1
AM - Armenia 1
BB - Barbados 1
BN - Brunei Darussalam 1
BS - Bahamas 1
BW - Botswana 1
CR - Costa Rica 1
EE - Estonia 1
GA - Gabon 1
GE - Georgia 1
GH - Ghana 1
Totale 16.800
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Città #
Hanover 1.929
Southend 1.135
Singapore 601
Ashburn 573
Fairfield 472
Dallas 435
Milan 396
Hong Kong 354
Frankfurt am Main 349
Chandler 342
Seattle 261
Beijing 255
Houston 241
Woodbridge 232
Wilmington 212
Cambridge 177
Dublin 164
Princeton 157
Council Bluffs 151
Ann Arbor 127
Los Angeles 110
Jakarta 103
Hefei 96
Toronto 94
Dearborn 81
Grafing 77
Guangzhou 72
New York 70
Bengaluru 69
Santa Clara 65
Buffalo 63
Shanghai 60
Columbus 58
Nanjing 58
Phoenix 56
Des Moines 55
Moscow 48
Munich 48
Rome 46
Andover 45
Tokyo 44
Ho Chi Minh City 42
Redwood City 41
San Diego 41
The Dalles 41
Berlin 39
Boardman 39
São Paulo 39
Nuremberg 35
Changsha 33
Seoul 33
Jinan 32
Shenyang 32
Cangzhou 31
Hangzhou 31
Helsinki 30
Silver Spring 28
London 27
Hanoi 26
Central District 25
Abidjan 23
Turin 23
Roxbury 22
Vienna 21
Chicago 20
Tianjin 20
Zhengzhou 20
Monza 19
San Francisco 19
Chongqing 18
Mumbai 17
Nanchang 17
Taipei 17
Wuhan 17
Amsterdam 16
Zurich 16
Chengdu 15
Redmond 15
Düsseldorf 14
Istanbul 14
Paris 14
Shenzhen 14
Brussels 13
Falls Church 13
Naples 13
Dong Ket 12
Florence 11
Johannesburg 11
Montreal 11
Rio de Janeiro 11
Ottawa 10
Pittsburgh 10
San Jose 10
Seongnam 10
Sydney 10
Trieste 10
Warsaw 10
Brooklyn 9
Chennai 9
Hebei 9
Totale 11.209
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Nome #
Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells 535
Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients 498
Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination 412
Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response 355
Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients 347
COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models 324
DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic 319
The association of IL28B genotype with the histological features of chronic hepatitis C is HCV genotype dependent 300
IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B 293
Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease 293
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion 288
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure 282
Anti-spike antibodies and neutralising antibody activity in people living with HIV vaccinated with COVID-19 mRNA-1273 vaccine: a prospective single-centre cohort study 256
The Enigmatic Role of Viruses in Multiple Sclerosis : Molecular Mimicry or Disturbed Immune Surveillance? 254
Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C 253
DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection 252
Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication? 251
Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment 236
Hepatitis C virus deletion mutants are found in individuals chronically infected with genotype 1 hepatitis c virus in association with age, high viral load and liver inflammatory activity 235
Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b 226
Interleukin 28B genotype and insulin resistance in chronic hepatitis C patients 217
Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants 213
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form 212
The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4 211
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor 211
Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells 207
A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand 205
New horizons in hepatitis C antiviral therapy with direct-acting antivirals 202
Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients 195
Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation 194
Naturally occurring hepatitis C virus subgenomic deletion mutants replicate efficiently in Huh-7 cells and are trans-packaged in vitro to generate infectious defective particles 193
A rapid and robust luciferase-based reporter system to assess SARS-CoV-2 protease activity 184
Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4 181
Hepatitis C virus NS5A is a direct substrate of casein kinase I-α, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors 178
Genetic variation in the interleukin-28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection 175
Daclatasvir : a team player rather than a prima donna in the treatment of hepatitis C 174
Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3 174
Novel interferon-sensitive genes unveiled by correlation-driven gene selection and systems biology 174
OXALAMIDO-SUBSTITUTED TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS 173
Characterization of the Inhibition of Hepatitis C Virus RNA Replication by Nonnucleosides 172
Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses 170
Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2 169
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain 167
Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site 165
NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains 164
Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations 162
The alpha isoform of protein kinase CKI is responsible for hepatitis C virus NS5A hyperphosphorylation 159
Inhibition of the lysine demethylase LSD1 modulates the balance between inflammatory and antiviral responses against coronaviruses 156
2-(2-thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: Discovery, SAR, modeling, and mutagenesis 154
HCV antiviral resistance: The impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase 152
Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking 150
B cell analyses after SARS-CoV-2 mRNA third vaccination reveals a hybrid immunity like antibody response 149
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases 148
Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture 145
Tricyclic inhibitors of hepatitis B virus 141
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex 140
Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase 135
Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity 134
Challenges and successes in developing new therapies for hepatitis C 133
Mutations in encephalomyocarditis virus 3A protein uncouple the dependency of genome replication on host factors phosphatidylinositol 4-kinase IIIα and oxysterol-binding protein 132
Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors 132
Flavodoxin-cytochrome c interactions : circular dichroism and nuclear magnetic resonance studies 129
Tracking the immune response profiles elicited by the BNT162b2 vaccine in COVID-19 unexperienced and experienced individuals 128
Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis 125
Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus 125
A series of novel, potent, and selective histone deacetylase inhibitors 125
Photodynamic antibacterial and antibiofilm activity of RLP068/Cl against Staphylococcus aureus and Pseudomonas aeruginosa forming biofilms on prosthetic material 124
Nirmatrelvir treatment of SARS-CoV-2-infected mice blunts antiviral adaptive immune responses 122
Why is it so difficult to develop a hepatitis C virus preventive vaccine? 122
Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase 122
Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase 120
Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity 119
DNA-Vaccine-Induced Immune Response Correlates with Lower Viral SARS-CoV-2 Titers in a Ferret Model 119
NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase III∝ complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes 118
Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators 116
Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines 116
Binding of a Noncovalent Inhibitor Exploiting the S′ region Stabilizes the Hepatitis C virus NS3 Protease Conformation in the Absence of Cofactor 115
Development and optimization of a binding assay for histone deacetylase 4 using surface plasmon resonance 114
HCVNS5b RNA-dependent RNA polymerase inhibitors: From alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids : design and synthesis 112
Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody 111
Typical NF2 and LTZR1 mutations are retained in an immortalized human schwann cell model of schwannomatosis 110
Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees 110
Isolation and Characterization of Neutralizing Monoclonal Antibodies from a Large Panel of Murine Antibodies against RBD of the SARS-CoV-2 Spike Protein 108
The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase 108
null 107
Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase 107
IL-10 promotes homeostatic proliferation of human CD8+ memory T cells and, when produced by CD1c+ DCs, shapes naive CD8+ T-cell priming 105
Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture 104
Immune response to SARS-COV-2 infection in patients with rheumatic musculoskeletal diseases: the mainstream study 103
A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies 103
Hepatitis C virus-specific directly acting antiviral drugs 103
Synthetic Carbohydrate Binding Agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2 103
In vitro antibiofilm activity of bioactive glass S53P4 92
Heterogeneity of Latency Establishment in the Different Human CD4+ T Cell Subsets Stimulated with IL-15 89
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination 79
Structural Basis for Resistance of the Genotype 2b Hepatitis C Virus NS5B Polymerase to Site A Non-Nucleoside Inhibitors 76
Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture 71
Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors 70
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases 58
A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo 50
Totale 17.349
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Categoria #
all - tutte 51.515
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 51.515
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021833 0 0 0 0 0 107 115 120 170 118 117 86
2021/20223.674 83 83 80 360 797 593 376 290 349 247 158 258
2022/20231.666 245 133 113 162 155 255 64 145 162 50 119 63
2023/20241.462 53 104 108 175 321 77 84 83 42 75 155 185
2024/20252.866 107 266 85 289 176 162 191 341 180 256 300 513
2025/20262.917 591 660 645 514 482 25 0 0 0 0 0 0
Totale 17.401