IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

DE FRANCESCO, RAFFAELE
 Distribuzione geografica
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Continente #
EU - Europa 7.383
NA - Nord America 6.553
AS - Asia 5.253
SA - Sud America 588
AF - Africa 132
OC - Oceania 69
Continente sconosciuto - Info sul continente non disponibili 3
Totale 19.981
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Nazione #
US - Stati Uniti d'America 6.300
DE - Germania 2.863
CN - Cina 1.684
SG - Singapore 1.563
GB - Regno Unito 1.360
IT - Italia 1.194
HK - Hong Kong 526
BR - Brasile 459
SE - Svezia 453
VN - Vietnam 440
RU - Federazione Russa 401
FR - Francia 263
IN - India 256
CA - Canada 188
BD - Bangladesh 176
IE - Irlanda 167
NL - Olanda 161
FI - Finlandia 160
ID - Indonesia 141
KR - Corea 108
JP - Giappone 82
DK - Danimarca 79
AU - Australia 61
TR - Turchia 50
AT - Austria 46
AR - Argentina 43
MX - Messico 39
IQ - Iraq 35
PH - Filippine 35
UA - Ucraina 34
CH - Svizzera 33
PL - Polonia 32
ES - Italia 30
ZA - Sudafrica 29
BE - Belgio 26
CI - Costa d'Avorio 23
TW - Taiwan 23
CO - Colombia 19
EC - Ecuador 18
PK - Pakistan 17
EG - Egitto 15
CL - Cile 14
KE - Kenya 14
SA - Arabia Saudita 14
AE - Emirati Arabi Uniti 13
VE - Venezuela 13
MY - Malesia 12
TH - Thailandia 12
CZ - Repubblica Ceca 11
MA - Marocco 11
UZ - Uzbekistan 11
RO - Romania 10
GR - Grecia 9
NZ - Nuova Zelanda 8
DZ - Algeria 7
IL - Israele 7
PE - Perù 7
ET - Etiopia 6
JO - Giordania 6
NP - Nepal 6
PT - Portogallo 6
SC - Seychelles 6
TN - Tunisia 6
UY - Uruguay 6
DO - Repubblica Dominicana 5
HU - Ungheria 5
IR - Iran 5
OM - Oman 5
PA - Panama 5
AZ - Azerbaigian 4
KZ - Kazakistan 4
LB - Libano 4
LV - Lettonia 4
NO - Norvegia 4
PY - Paraguay 4
SI - Slovenia 4
SN - Senegal 4
BG - Bulgaria 3
EU - Europa 3
GT - Guatemala 3
JM - Giamaica 3
KG - Kirghizistan 3
LT - Lituania 3
LU - Lussemburgo 3
MK - Macedonia 3
RS - Serbia 3
SK - Slovacchia (Repubblica Slovacca) 3
AL - Albania 2
BH - Bahrain 2
BO - Bolivia 2
BY - Bielorussia 2
CR - Costa Rica 2
GA - Gabon 2
GE - Georgia 2
GY - Guiana 2
MD - Moldavia 2
MT - Malta 2
NG - Nigeria 2
TT - Trinidad e Tobago 2
UG - Uganda 2
Totale 19.960
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Città #
Hanover 1.929
Southend 1.135
Singapore 864
Ashburn 680
Fairfield 472
Hong Kong 449
Dallas 436
Milan 412
San Jose 389
Frankfurt am Main 359
Chandler 342
Beijing 271
Seattle 265
Council Bluffs 247
Houston 243
Woodbridge 232
Wilmington 212
Cambridge 177
Dublin 166
Los Angeles 162
Princeton 157
Ho Chi Minh City 139
Ann Arbor 128
New York 124
Hanoi 121
Helsinki 118
Jakarta 103
Toronto 99
Hefei 96
Lauterbourg 96
Guangzhou 93
Santa Clara 87
Dearborn 82
Buffalo 78
Grafing 77
Shanghai 74
Bengaluru 69
Phoenix 66
Rome 64
Moscow 62
Nanjing 62
Columbus 60
Des Moines 55
Tokyo 51
Munich 48
San Diego 48
São Paulo 46
Andover 45
The Dalles 45
Redwood City 41
Seoul 40
Berlin 39
Boardman 39
Changsha 36
Nuremberg 36
Hangzhou 34
Jinan 33
Shenyang 33
Turin 32
Cangzhou 31
London 31
Amsterdam 29
Silver Spring 28
Atlanta 27
Chicago 26
Central District 25
Zhengzhou 24
Abidjan 23
Vienna 23
Da Nang 22
Roxbury 22
San Francisco 22
Tianjin 21
Washington 21
Chongqing 20
Monza 20
Mumbai 19
Wuhan 19
Nanchang 18
Naples 17
Taipei 17
Warsaw 17
Zurich 17
Montreal 16
Paris 16
Chengdu 15
Istanbul 15
Redmond 15
Shenzhen 15
Düsseldorf 14
Haiphong 14
Johannesburg 14
Sydney 14
Brussels 13
Falls Church 13
Chennai 12
Dong Ket 12
Florence 12
Manila 12
Nairobi 12
Totale 12.971
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Nome #
Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells 575
Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients 571
Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination 459
Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response 405
Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients 390
DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic 370
COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models 355
IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B 354
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion 345
The association of IL28B genotype with the histological features of chronic hepatitis C is HCV genotype dependent 344
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure 332
Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease 318
DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection 305
Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C 304
Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication? 303
Anti-spike antibodies and neutralising antibody activity in people living with HIV vaccinated with COVID-19 mRNA-1273 vaccine: a prospective single-centre cohort study 295
Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment 287
The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4 282
The Enigmatic Role of Viruses in Multiple Sclerosis : Molecular Mimicry or Disturbed Immune Surveillance? 276
Interleukin 28B genotype and insulin resistance in chronic hepatitis C patients 267
Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants 267
Hepatitis C virus deletion mutants are found in individuals chronically infected with genotype 1 hepatitis c virus in association with age, high viral load and liver inflammatory activity 260
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form 258
A rapid and robust luciferase-based reporter system to assess SARS-CoV-2 protease activity 253
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor 251
Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b 249
Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation 230
New horizons in hepatitis C antiviral therapy with direct-acting antivirals 229
Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2 228
A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand 227
Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells 226
Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients 219
Naturally occurring hepatitis C virus subgenomic deletion mutants replicate efficiently in Huh-7 cells and are trans-packaged in vitro to generate infectious defective particles 216
OXALAMIDO-SUBSTITUTED TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS 216
Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4 209
Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3 208
Genetic variation in the interleukin-28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection 206
Novel interferon-sensitive genes unveiled by correlation-driven gene selection and systems biology 204
Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations 199
Characterization of the Inhibition of Hepatitis C Virus RNA Replication by Nonnucleosides 199
Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses 198
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain 198
Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site 198
The alpha isoform of protein kinase CKI is responsible for hepatitis C virus NS5A hyperphosphorylation 197
Hepatitis C virus NS5A is a direct substrate of casein kinase I-α, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors 194
Inhibition of the lysine demethylase LSD1 modulates the balance between inflammatory and antiviral responses against coronaviruses 192
B cell analyses after SARS-CoV-2 mRNA third vaccination reveals a hybrid immunity like antibody response 192
Daclatasvir : a team player rather than a prima donna in the treatment of hepatitis C 191
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex 189
HCV antiviral resistance: The impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase 183
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases 182
2-(2-thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: Discovery, SAR, modeling, and mutagenesis 181
NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains 180
Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking 179
DNA-Vaccine-Induced Immune Response Correlates with Lower Viral SARS-CoV-2 Titers in a Ferret Model 172
Tricyclic inhibitors of hepatitis B virus 172
Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees 170
Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture 169
Tracking the immune response profiles elicited by the BNT162b2 vaccine in COVID-19 unexperienced and experienced individuals 168
Mutations in encephalomyocarditis virus 3A protein uncouple the dependency of genome replication on host factors phosphatidylinositol 4-kinase IIIα and oxysterol-binding protein 164
Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors 162
Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators 157
Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody 157
Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity 156
Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity 155
Photodynamic antibacterial and antibiofilm activity of RLP068/Cl against Staphylococcus aureus and Pseudomonas aeruginosa forming biofilms on prosthetic material 152
Synthetic Carbohydrate Binding Agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2 150
Isolation and Characterization of Neutralizing Monoclonal Antibodies from a Large Panel of Murine Antibodies against RBD of the SARS-CoV-2 Spike Protein 148
IL-10 promotes homeostatic proliferation of human CD8+ memory T cells and, when produced by CD1c+ DCs, shapes naive CD8+ T-cell priming 148
Typical NF2 and LTZR1 mutations are retained in an immortalized human schwann cell model of schwannomatosis 147
Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis 147
Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase 147
Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase 146
Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines 144
Challenges and successes in developing new therapies for hepatitis C 144
Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus 144
Flavodoxin-cytochrome c interactions : circular dichroism and nuclear magnetic resonance studies 143
Why is it so difficult to develop a hepatitis C virus preventive vaccine? 141
A series of novel, potent, and selective histone deacetylase inhibitors 141
NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase III∝ complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes 140
Heterogeneity of Latency Establishment in the Different Human CD4+ T Cell Subsets Stimulated with IL-15 139
Nirmatrelvir treatment of SARS-CoV-2-infected mice blunts antiviral adaptive immune responses 135
HCVNS5b RNA-dependent RNA polymerase inhibitors: From alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids : design and synthesis 133
Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture 132
Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase 131
Binding of a Noncovalent Inhibitor Exploiting the S′ region Stabilizes the Hepatitis C virus NS3 Protease Conformation in the Absence of Cofactor 130
Development and optimization of a binding assay for histone deacetylase 4 using surface plasmon resonance 124
Immune response to SARS-COV-2 infection in patients with rheumatic musculoskeletal diseases: the mainstream study 123
The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase 122
Hepatitis C virus-specific directly acting antiviral drugs 113
A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies 112
Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase 112
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination 111
null 107
In vitro antibiofilm activity of bioactive glass S53P4 104
Structural Basis for Resistance of the Genotype 2b Hepatitis C Virus NS5B Polymerase to Site A Non-Nucleoside Inhibitors 98
Biomimetic Recognition of SARS-CoV-2 Receptor-Binding Domain N-Glycans by an Antiviral Synthetic Receptor 89
Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors 89
Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture 89
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases 73
Totale 20.595
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Categoria #
all - tutte 57.457
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 57.457
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021203 0 0 0 0 0 0 0 0 0 0 117 86
2021/20223.674 83 83 80 360 797 593 376 290 349 247 158 258
2022/20231.666 245 133 113 162 155 255 64 145 162 50 119 63
2023/20241.462 53 104 108 175 321 77 84 83 42 75 155 185
2024/20252.866 107 266 85 289 176 162 191 341 180 256 300 513
2025/20266.212 591 660 645 514 482 379 915 327 691 487 521 0
Totale 20.696