IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

DE FRANCESCO, RAFFAELE
 Distribuzione geografica
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Continente #
EU - Europa 7.563
NA - Nord America 7.026
AS - Asia 5.470
SA - Sud America 598
AF - Africa 132
OC - Oceania 70
Continente sconosciuto - Info sul continente non disponibili 3
Totale 20.862
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Nazione #
US - Stati Uniti d'America 6.749
DE - Germania 2.867
CN - Cina 1.687
SG - Singapore 1.571
IT - Italia 1.364
GB - Regno Unito 1.361
HK - Hong Kong 527
BR - Brasile 462
SE - Svezia 453
VN - Vietnam 445
RU - Federazione Russa 401
BD - Bangladesh 372
FR - Francia 263
IN - India 256
CA - Canada 202
IE - Irlanda 167
NL - Olanda 163
FI - Finlandia 160
ID - Indonesia 141
KR - Corea 108
JP - Giappone 83
DK - Danimarca 79
AU - Australia 62
TR - Turchia 51
AT - Austria 46
AR - Argentina 45
MX - Messico 39
IQ - Iraq 35
PH - Filippine 35
UA - Ucraina 34
CH - Svizzera 33
ES - Italia 32
PL - Polonia 32
ZA - Sudafrica 29
BE - Belgio 26
CI - Costa d'Avorio 23
TW - Taiwan 23
CO - Colombia 21
EC - Ecuador 19
PK - Pakistan 18
CL - Cile 15
EG - Egitto 15
KE - Kenya 14
SA - Arabia Saudita 14
VE - Venezuela 14
AE - Emirati Arabi Uniti 13
MY - Malesia 12
TH - Thailandia 12
CZ - Repubblica Ceca 11
MA - Marocco 11
UZ - Uzbekistan 11
RO - Romania 10
GR - Grecia 9
NZ - Nuova Zelanda 8
DZ - Algeria 7
IL - Israele 7
PE - Perù 7
ET - Etiopia 6
JM - Giamaica 6
JO - Giordania 6
NP - Nepal 6
PT - Portogallo 6
SC - Seychelles 6
TN - Tunisia 6
UY - Uruguay 6
AZ - Azerbaigian 5
CR - Costa Rica 5
DO - Repubblica Dominicana 5
GT - Guatemala 5
HU - Ungheria 5
IR - Iran 5
OM - Oman 5
PA - Panama 5
SI - Slovenia 5
KZ - Kazakistan 4
LB - Libano 4
LV - Lettonia 4
NO - Norvegia 4
PY - Paraguay 4
SN - Senegal 4
BG - Bulgaria 3
EU - Europa 3
KG - Kirghizistan 3
LT - Lituania 3
LU - Lussemburgo 3
MK - Macedonia 3
RS - Serbia 3
SK - Slovacchia (Repubblica Slovacca) 3
AL - Albania 2
BH - Bahrain 2
BO - Bolivia 2
BY - Bielorussia 2
GA - Gabon 2
GE - Georgia 2
GY - Guiana 2
HN - Honduras 2
MD - Moldavia 2
MT - Malta 2
NG - Nigeria 2
TT - Trinidad e Tobago 2
Totale 20.839
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Città #
Hanover 1.929
Southend 1.135
Singapore 868
Ashburn 771
Fairfield 472
Hong Kong 450
Dallas 439
Milan 426
San Jose 401
Frankfurt am Main 359
Chandler 342
Council Bluffs 274
Beijing 272
Seattle 269
Houston 246
Woodbridge 232
Wilmington 212
Los Angeles 182
Cambridge 178
Dublin 166
Santa Clara 160
Princeton 157
Ho Chi Minh City 140
New York 138
Ann Arbor 128
Hanoi 121
Helsinki 118
Jakarta 103
Toronto 101
Hefei 96
Lauterbourg 96
Guangzhou 93
Buffalo 89
Dearborn 82
Rome 80
Grafing 77
Shanghai 75
Bengaluru 69
Boardman 68
Phoenix 68
Moscow 62
Nanjing 62
Columbus 61
Des Moines 56
Tokyo 52
Munich 48
San Diego 48
The Dalles 48
São Paulo 46
Andover 45
Berlin 41
Redwood City 41
Turin 41
Seoul 40
Changsha 36
Nuremberg 36
Hangzhou 34
Jinan 33
Shenyang 33
London 32
Cangzhou 31
Chicago 30
Amsterdam 29
Silver Spring 28
Atlanta 27
Naples 26
Central District 25
Washington 24
Zhengzhou 24
Abidjan 23
San Francisco 23
Vienna 23
Da Nang 22
Monza 22
Roxbury 22
Tianjin 21
Chongqing 20
Mumbai 19
Wuhan 19
Florence 18
Montreal 18
Nanchang 18
Taipei 17
Warsaw 17
Zurich 17
Paris 16
Chengdu 15
Istanbul 15
Redmond 15
Shenzhen 15
Düsseldorf 14
Falls Church 14
Haiphong 14
Johannesburg 14
Sydney 14
Bologna 13
Brooklyn 13
Brussels 13
Orem 13
Boston 12
Totale 13.350
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Nome #
Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells 586
Integrated longitudinal immunophenotypic, transcriptional and repertoire analyses delineate immune responses in COVID-19 patients 585
Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination 465
Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response 419
Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients 417
DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic 382
IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B 371
COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models 360
The association of IL28B genotype with the histological features of chronic hepatitis C is HCV genotype dependent 354
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion 349
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure 346
Interaction between PNPLA3 I148M variant and age at infection in determining fibrosis progression in chronic hepatitis C 323
Rare Pathogenic Variants Predispose to Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease 322
Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication? 318
DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection 315
Anti-spike antibodies and neutralising antibody activity in people living with HIV vaccinated with COVID-19 mRNA-1273 vaccine: a prospective single-centre cohort study 312
Nanoparticle‐Mediated Suicide Gene Therapy for Triple Negative Breast Cancer Treatment 305
The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4 293
The Enigmatic Role of Viruses in Multiple Sclerosis : Molecular Mimicry or Disturbed Immune Surveillance? 288
Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants 276
Interleukin 28B genotype and insulin resistance in chronic hepatitis C patients 275
Hepatitis C virus deletion mutants are found in individuals chronically infected with genotype 1 hepatitis c virus in association with age, high viral load and liver inflammatory activity 273
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form 266
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor 262
A rapid and robust luciferase-based reporter system to assess SARS-CoV-2 protease activity 259
Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b 252
Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2 239
New horizons in hepatitis C antiviral therapy with direct-acting antivirals 238
Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation 236
A functionally orthogonal estrogen receptor-based transcription switch specifically induced by a nonsteroid synthetic ligand 231
Transmembrane 6 superfamily member 2 gene E167K variant impacts on steatosis and liver damage in chronic hepatitis C patients 230
Interleukin 28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis C genotype 4 228
Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells 228
Ezrin is a specific and direct target of protein tyrosine phosphatase PRL-3 221
Naturally occurring hepatitis C virus subgenomic deletion mutants replicate efficiently in Huh-7 cells and are trans-packaged in vitro to generate infectious defective particles 220
OXALAMIDO-SUBSTITUTED TRICYCLIC INHIBITORS OF HEPATITIS B VIRUS 220
Genetic variation in the interleukin-28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection 218
Novel interferon-sensitive genes unveiled by correlation-driven gene selection and systems biology 218
Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses 217
Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations 216
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain 210
Characterization of the Inhibition of Hepatitis C Virus RNA Replication by Nonnucleosides 205
Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking 204
Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site 203
B cell analyses after SARS-CoV-2 mRNA third vaccination reveals a hybrid immunity like antibody response 203
Hepatitis C virus NS5A is a direct substrate of casein kinase I-α, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors 202
The alpha isoform of protein kinase CKI is responsible for hepatitis C virus NS5A hyperphosphorylation 202
Daclatasvir : a team player rather than a prima donna in the treatment of hepatitis C 201
Inhibition of the lysine demethylase LSD1 modulates the balance between inflammatory and antiviral responses against coronaviruses 198
Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex 196
HCV antiviral resistance: The impact of in vitro studies on the development of antiviral agents targeting the viral NS5B polymerase 191
Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody 189
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases 187
DNA-Vaccine-Induced Immune Response Correlates with Lower Viral SARS-CoV-2 Titers in a Ferret Model 183
2-(2-thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: Discovery, SAR, modeling, and mutagenesis 183
NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains 182
Tracking the immune response profiles elicited by the BNT162b2 vaccine in COVID-19 unexperienced and experienced individuals 179
Reduction of hepatitis C virus NS5A hyperphosphorylation by selective inhibition of cellular kinases activates viral RNA replication in cell culture 178
Tricyclic inhibitors of hepatitis B virus 178
Anatomy of Omicron BA.1 and BA.2 neutralizing antibodies in COVID-19 mRNA vaccinees 174
Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators 170
Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors 169
Heterogeneity of Latency Establishment in the Different Human CD4+ T Cell Subsets Stimulated with IL-15 169
Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity 168
Mutations in encephalomyocarditis virus 3A protein uncouple the dependency of genome replication on host factors phosphatidylinositol 4-kinase IIIα and oxysterol-binding protein 168
Photodynamic antibacterial and antibiofilm activity of RLP068/Cl against Staphylococcus aureus and Pseudomonas aeruginosa forming biofilms on prosthetic material 167
Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity 162
IL-10 promotes homeostatic proliferation of human CD8+ memory T cells and, when produced by CD1c+ DCs, shapes naive CD8+ T-cell priming 162
Synthetic Carbohydrate Binding Agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2 161
Isolation and Characterization of Neutralizing Monoclonal Antibodies from a Large Panel of Murine Antibodies against RBD of the SARS-CoV-2 Spike Protein 152
Typical NF2 and LTZR1 mutations are retained in an immortalized human schwann cell model of schwannomatosis 152
Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase 151
Nirmatrelvir treatment of SARS-CoV-2-infected mice blunts antiviral adaptive immune responses 150
Mechanism of hepatitis C virus RNA polymerase inhibition with dihydroxypyrimidines 149
Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis 148
Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase 148
Challenges and successes in developing new therapies for hepatitis C 146
NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase III∝ complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes 144
Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture 144
Flavodoxin-cytochrome c interactions : circular dichroism and nuclear magnetic resonance studies 144
Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus 144
A series of novel, potent, and selective histone deacetylase inhibitors 144
Why is it so difficult to develop a hepatitis C virus preventive vaccine? 142
Immune response to SARS-COV-2 infection in patients with rheumatic musculoskeletal diseases: the mainstream study 135
HCVNS5b RNA-dependent RNA polymerase inhibitors: From alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids : design and synthesis 135
Binding of a Noncovalent Inhibitor Exploiting the S′ region Stabilizes the Hepatitis C virus NS3 Protease Conformation in the Absence of Cofactor 133
Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase 133
Development and optimization of a binding assay for histone deacetylase 4 using surface plasmon resonance 127
The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase 123
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination 119
Hepatitis C virus-specific directly acting antiviral drugs 115
A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies 114
Potent inhibitors of subgenomic hepatitis C virus RNA replication through optimization of indole-N-acetamide allosteric inhibitors of the viral NS5B polymerase 113
null 107
In vitro antibiofilm activity of bioactive glass S53P4 106
Biomimetic Recognition of SARS-CoV-2 Receptor-Binding Domain N-Glycans by an Antiviral Synthetic Receptor 100
Structural Basis for Resistance of the Genotype 2b Hepatitis C Virus NS5B Polymerase to Site A Non-Nucleoside Inhibitors 100
Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture 91
Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors 90
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases 75
Totale 21.451
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Categoria #
all - tutte 60.019
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 60.019
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20223.674 83 83 80 360 797 593 376 290 349 247 158 258
2022/20231.666 245 133 113 162 155 255 64 145 162 50 119 63
2023/20241.462 53 104 108 175 321 77 84 83 42 75 155 185
2024/20252.866 107 266 85 289 176 162 191 341 180 256 300 513
2025/20266.847 591 660 645 514 482 379 915 327 691 487 619 537
2026/2027246 246 0 0 0 0 0 0 0 0 0 0 0
Totale 21.577