Multiple sclerosis (MS) is a T cell driven autoimmune disease of the central nervous system (CNS). Despite its association with Epstein-Barr Virus (EBV), how viral infections promote MS remains unclear. However, there is increasing evidence that the CNS is continuously surveyed by virus-specific T cells, which protect against reactivating neurotropic viruses. Here, we discuss how viral infections could lead to the breakdown of self-tolerance in genetically predisposed individuals, and how the reactivations of viruses in the CNS could induce the recruitment of both autoaggressive and virus-specific T cell subsets, causing relapses and progressive disability. A disturbed immune surveillance in MS would explain several experimental findings, and has important implications for prognosis and therapy.
The Enigmatic Role of Viruses in Multiple Sclerosis : Molecular Mimicry or Disturbed Immune Surveillance? / J. Geginat, M. Paroni, M. Pagani, D. Galimberti, R. De Francesco, E. Scarpini, S. Abrignani. - In: TRENDS IN IMMUNOLOGY. - ISSN 1471-4906. - 38:7(2017 Jul), pp. 498-512.
|Titolo:||The Enigmatic Role of Viruses in Multiple Sclerosis : Molecular Mimicry or Disturbed Immune Surveillance?|
PARONI, MOIRA (Secondo)
SCARPINI, ELIO ANGELO (Penultimo)
ABRIGNANI, SERGIO (Ultimo)
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
Settore MED/07 - Microbiologia e Microbiologia Clinica
|Data di pubblicazione:||lug-2017|
|Data ahead of print / Data di stampa:||23-mag-2017|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.it.2017.04.006|
|Appare nelle tipologie:||01 - Articolo su periodico|