The RNA replication machinery of HCV is a multi-subunit membrane-associated complex. NS5A has emerged as an active component of HCV replicase, possibly involved in regulation of viral replication and resistance to the antiviral effect of interferon. We report here substituted piperazinyl-N-(aryl)benzamides as potent inhibitors of HCV replication exerted via modulation of the dimerization of NS5A.

Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture / I. Conte, C. Giuliano, C. Ercolani, F. Narjes, U. Koch, M. Rowley, S. Altamura, R.D. Francesco, P. Neddermann, G. Migliaccio, I. Stansfield. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 19:6(2009), pp. 1779-1783.

Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture

Francesco, Raffaele De;
2009

Abstract

The RNA replication machinery of HCV is a multi-subunit membrane-associated complex. NS5A has emerged as an active component of HCV replicase, possibly involved in regulation of viral replication and resistance to the antiviral effect of interferon. We report here substituted piperazinyl-N-(aryl)benzamides as potent inhibitors of HCV replication exerted via modulation of the dimerization of NS5A.
Hepatitis C virus; Modulation of the dimerization of NS5A; Substituted piperazinyl-N-(aryl)benzamides
Settore BIO/14 - Farmacologia
Settore BIO/13 - Biologia Applicata
Settore BIO/19 - Microbiologia Generale
Settore BIO/11 - Biologia Molecolare
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Article (author)
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0960894X09000869-main.pdf

non disponibili

2.29 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/634742
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 31
social impact