IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

DE AMICI, MARCO
 Distribuzione geografica
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Continente #
EU - Europa 11.000
NA - Nord America 6.039
AS - Asia 4.116
SA - Sud America 128
AF - Africa 49
OC - Oceania 38
Continente sconosciuto - Info sul continente non disponibili 10
Totale 21.380
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Nazione #
US - Stati Uniti d'America 5.919
GB - Regno Unito 3.342
DE - Germania 2.086
IT - Italia 1.668
CN - Cina 1.381
SE - Svezia 1.204
RU - Federazione Russa 985
SG - Singapore 751
IN - India 462
TR - Turchia 403
HK - Hong Kong 349
KR - Corea 337
IE - Irlanda 317
FR - Francia 297
UA - Ucraina 265
FI - Finlandia 201
NL - Olanda 180
EU - Europa 148
JP - Giappone 103
ES - Italia 100
ID - Indonesia 100
DK - Danimarca 97
CA - Canada 96
PH - Filippine 67
GR - Grecia 64
CO - Colombia 58
BR - Brasile 43
BE - Belgio 41
AU - Australia 36
VN - Vietnam 34
IR - Iran 32
CH - Svizzera 30
RO - Romania 23
MX - Messico 21
TW - Taiwan 21
PL - Polonia 20
AT - Austria 19
PK - Pakistan 19
IL - Israele 13
CL - Cile 12
CZ - Repubblica Ceca 12
NO - Norvegia 11
TH - Thailandia 9
MA - Marocco 8
TN - Tunisia 7
HU - Ungheria 6
NG - Nigeria 6
PT - Portogallo 6
RS - Serbia 6
CM - Camerun 5
EG - Egitto 5
MY - Malesia 5
PE - Perù 5
ZA - Sudafrica 5
HR - Croazia 4
JO - Giordania 4
SC - Seychelles 4
UZ - Uzbekistan 4
AE - Emirati Arabi Uniti 3
AL - Albania 3
AR - Argentina 3
BG - Bulgaria 3
EC - Ecuador 3
ET - Etiopia 3
SA - Arabia Saudita 3
UY - Uruguay 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AZ - Azerbaigian 2
BH - Bahrain 2
BW - Botswana 2
BY - Bielorussia 2
HN - Honduras 2
IQ - Iraq 2
IS - Islanda 2
KZ - Kazakistan 2
LK - Sri Lanka 2
NZ - Nuova Zelanda 2
SK - Slovacchia (Repubblica Slovacca) 2
TZ - Tanzania 2
BA - Bosnia-Erzegovina 1
BD - Bangladesh 1
BO - Bolivia 1
CR - Costa Rica 1
CY - Cipro 1
DZ - Algeria 1
KG - Kirghizistan 1
LV - Lettonia 1
MK - Macedonia 1
MM - Myanmar 1
MN - Mongolia 1
MT - Malta 1
PS - Palestinian Territory 1
ZW - Zimbabwe 1
Totale 21.520
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Città #
Southend 3.092
Hanover 981
Chandler 707
Singapore 546
Milan 536
Seattle 522
Princeton 419
Wilmington 330
Dublin 308
Beijing 281
Ashburn 267
Munich 253
Ann Arbor 244
Mountain View 220
Redmond 215
Santa Clara 182
Dearborn 167
Jacksonville 154
Nanjing 151
Fairfield 129
Boardman 128
Woodbridge 127
Des Moines 126
Sakarya 117
Berlin 107
Bengaluru 101
Houston 99
Hong Kong 97
Jinan 80
Somerville 80
Rome 77
Serra 70
Shanghai 69
Shenyang 69
Cambridge 66
Redwood City 63
Athens 61
Andover 60
Jakarta 59
Barcelona 58
Bogotá 56
Medford 51
Frankfurt am Main 50
Toronto 50
Würzburg 49
Hebei 44
Nanchang 44
New York 42
San Diego 41
Sunnyvale 40
Istanbul 39
Los Angeles 38
Changsha 36
Mumbai 36
Tianjin 35
Eitensheim 34
Brussels 33
Guangzhou 31
Ningbo 29
Bühl 28
Bitonto 27
Tokyo 27
Grafing 26
Zhengzhou 25
Kunming 24
London 24
Naples 24
Fuzhou 22
Hangzhou 22
Hamburg 21
Helsinki 21
Phoenix 21
Kent 20
Hefei 19
Quanzhou 19
Wuhan 19
Dong Ket 18
Jiaxing 18
Nuremberg 18
Turin 18
Boston 17
Norwalk 17
Seoul 17
Brescia 16
Chicago 16
Mannheim 16
Seongnam 16
Auburn Hills 15
Falls Church 15
Florence 14
Haikou 14
Nürnberg 14
Piscataway 14
San Jose 14
São Paulo 14
Tappahannock 14
Vienna 14
Amsterdam 13
Pune 13
Zurich 13
Totale 12.953
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Nome #
Agonisti nicotinici selettivi nel trattamento di patologie del Sistema Nervoso Centrale 422
Epiboxidine and Novel Related Analogues : a Convenient Synthetic Approach and Estimation of Their Affinity at Neuronal Nicotinic Acetylcholine Receptor Subtypes 392
Agenti Adrenergici 354
Combined treatments with the dualsteric agonist N-8-Iper plus chemotherapy drugs affect drug resistance in glioblastoma cancer stem cells 308
Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes 270
2020 Italian special anniversary collection : Celebrating NMMC 2019 and 40 Years of the DCF-SCI 230
Synthesis and pharmacological characterization at glutamate receptors of erythro- and threo-tricholomic acid and homologues thereof 221
The Mechanisms Mediated by α7 Acetylcholine Nicotinic Receptors May Contribute to Peripheral Nerve Regeneration 218
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling 212
Selective agonists for M2 muscarinic receptors inhibit cell proliferation and survival in human glioblastoma cells: Possible implications in drug resistance 209
Photoswitchable ligands for the optical control of α7 nicotinic acetylcholine receptors: synthesis and photochromic characterization 193
Synthesis and structure-activity relationships in a set of new antimuscarinic agents 191
New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus: Synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations 190
The impact of Chirality on Medicinal Chemistry 179
A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitors 176
Orthosteric and allosteric ligands selectively acting at cholinergic receptor subtypes 170
(Trans)dermal delivery of opioids: a structure-permeability relationship 167
Novel pharmacological tools which activate mAChRs: a question of "dualsterism" 165
Synthesis of epibatidine-related Delta(2)-isoxazoline derivatives and evaluation of their binding affinity at neuronal nicotinic acetylcholine receptors 163
Chemotherapy-induced neuropathy: involvement of the alpha7 nAChR subtype 161
Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes 159
Alpha7 nAChR: pathogenesis and treatment of chemotherapy-induced neuropathy 158
Allosteric ligands for G protein-coupled receptors : a novel strategy with attractive therapeutic opportunities 157
Alpha7 nicotinic acetylcholine receptor agonists: prediction of their binding affinity through a molecular mechanics poisson-boltzmann surface area approach 156
Design of Cyclopentaisoxazoline Amino Acids as Conformationally Constrained Agonists at Glutamate Receptors 155
Synthesis, Binding Affinity at Glutamic Acid Receptors, Neuroprotective Effects, and Molecular Modeling Investigation of Novel Dihydroisoxazole Amino Acids 155
Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters 154
In silico design of agonists targeting the alpha7 nicotinic acetylcholine receptors, their synthesis and preliminary pharmacological evaluation 153
Design and synthesis of selective ligands targeting different nAChR subtypes 152
Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors 152
Design, Synthesis, and Pharmacological Characterization of Novel Spirocyclic Quinuclidinyl-Δ2-Isoxazoline Derivatives as Potent and Selective Agonists of α7 Nicotinic Acetylcholine Receptors 150
Novel ligands for neuronal nicotinic receptor subtypes: synthetic, pharmacological and molecular docking studies 149
Determination of acid dissociation constants of compounds active at neuronal nicotinic acetylcholine receptors by means of electrophoretic and potentiometric techniques 148
Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake 143
Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-Coupled Receptor 143
Synthesis and biological evaluation of new amino acids structurally related to the antitumor agent acivicin 142
Synthesis and Anticonvulsant Activity of Novel Bicyclic Acidic Amino Acids 141
The enantiomers of epiboxidine: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes 141
Synthesis and characterization of 13C labeled carnosine derivatives for isotope dilution mass spectrometry measurements in biological matrices 141
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid 140
Synthesis of pyrrol-3-yl-ethanolamines 140
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype [Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the alpha 3 beta 4 nicotinic acetylcholine receptor subtype] 139
Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: Synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity 138
A new synthesis of (D,L)-muscarone via 1,3-dipolar cycloaddition 137
Activation of M2 muscarinic acetylcholine receptors by orthosteric and dualsteric agonists in glioblastoma cancer stem cells: effects on cell proliferation and drug resistance 136
Synthesis of enantiopure Delta(2)-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes 135
Nuovi ligandi nicotinici correlati all'Epibatidina e all'Epibossidina: sintesi e valutazione della loro affinità per i recettori nicotinici neuronali alpha4beta2 e alpha7 135
Novel Analgesic Agents Obtained by Molecular Hybridization of Orthosteric and Allosteric Ligands 135
Synthesis and pharmacological characterization of new analogs of broxaterol 133
Analgesic effects mediated by muscarinic ligands acting at both orthosteric and allosteric receptor binding sites 132
Allosteric modulation of alpha7 nicotinic receptors : mechanistic insight through metadynamics and essential dynamics 132
Synthesis of new Delta(2)-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists 131
Dualsteric compounds modulate the signaling pattern of muscarinic M1 acetylcholine receptors 130
Determination of acid dissociation constants of poorly water-soluble nicotinic ligands by means of electrophoretic and potentiometric techniques 129
Peptide derivatives and therapeutic activity thereof 129
Photoswitchable ligands for light-mediated control of α7 nicotinic acetylcholine receptors: design, synthesis and photochromic characterization 129
Nicotinic agonists selective for the Alpha7 Receptor Subtype, the process for their preparation thereof and pharmaceutical compositions therefrom 128
A Combinatorial Biocatalysis Approach to an Array of Cholic Acid Derivatives 127
Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors 127
New spirocyclic Δ2-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors 125
Dualsteric activation of M2 muscarinic acetylcholine receptors inhibits cell proliferation in human glioblastoma cell lines 125
Design, synthesis and pharmacological properties of alkylbisammonio bitopic ligands of muscarinic acetylcholine receptors 124
Nicotinic anti-inflammatory pathway: a new target to control low-grade inflammation and glucose homeostasis in obesity 124
Synthesis and application of isotope-labeled carnosine in LCMS/MS 124
New hybrid muscarinic agonists: in vitro functional characterization and in vivo analgesic activity evaluation 123
Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor 123
Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization 123
Design of Novel Conformationally Restricted Analogues of Glutamic Acid 122
Design of novel α7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies 122
Progettazione e sintesi di analoghi strutturali dell’Epibossodina 122
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF THE 3-ANALOGS OF VIMINOL 122
AN EASY SYNTHESIS OF DIHYDROMUSCIMOL 122
Epiboxidine and Novel-Related Analogues: A Convenient Synthetic Approach and Estimation of Their at Neuronal Nicotinic Acetylcholine Receptor Subtypes 122
The enantiomers of epiboxidine and of two related analogs: Synthesis and estimation of their binding affinity at α4β2 and α7 neuronal nicotinic acetylcholine receptors 121
Activation of M2 muscarinic acetylcholine receptors by a hybrid agonist enhances cytotoxic effects in GB7 glioblastoma cancer stem cells 120
Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation 120
Development of a Three-Dimensional Model for the N-Methyl-D-aspartate NR2A Subunit 118
Synthesis of novel enantiopure 2-isoxazoline and 2-pyrazoline amino acids and their activity at glutamic acid receptors and transporters 117
Synthesis and binding affinity at α4β2 and α7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system 117
Novel bicylic delta2-isoxazoline and 3-oxo-isoxazolidine derivatives : synthesis and binding affinity at neuronal nicotinic receptor subtypes 116
Tacrine/Xanomeline hybrid ligands: synthesis and pharmacological evaluation at M1 muscarinic acetylcholine receptors and acetylcholinesterases 116
beta(3)-adrenergic receptor ligands: insight into structure-activity relationships using Monte-Carlo conformational analysis in water 115
Selective nicotinic agonists to treat pathologies of the central nervous system 114
Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists 113
Chemoenzymatic synthesis of the enantiomers of desoxymuscarine 113
A chemoenzymatic approach to the synthesis of the stereoisomers of a beta-adrenergic receptor antagonist 113
AN EFFICIENT SYNTHESIS OF ISOXAZOLES AND ISOXAZOLINES 113
Synthesis of 3-benzenesulfonylisoxazolines and isoxazolidines 113
Synthesis of novel epibatidine-related derivatives through 1,3-dipolar cycloaddition of pyridinenitrile oxides 112
Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation 112
Pharmacological profile of enantiomerically pure chiral muscarinic agonists - Desoxymuscarines 111
METAL-HYDRIDE REDUCTION OF ISOXAZOLINE-3-CARBOXYLATE ESTERS 111
The novel hybrid agonist HyNDA-1 targets the D3R-nAChR heteromeric complex in dopaminergic neurons 111
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF CHOLINERGIC LIGANDS STRUCTURALLY RELATED TO MUSCARONE 110
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF STEREOISOMERIC MUSCARINES 110
Iperoxo/dequalinium and W84/dequalinium hybrid ligands: synthesis, pharmacological and computational investigation at M2 mAChRs 109
Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine 108
Relative potencies of the stereoisomers of bethanechol on muscarinic receptor 108
SYNTHESIS, BIOLOGICAL-ACTIVITY AND CONFORMATIONAL-ANALYSIS OF SOME ACYCLIC CHOLINERGIC LIGANDS 107
Allosteric modulators and selective agonists of muscarinic receptors 106
Totale 14.879
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Categoria #
all - tutte 65.066
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 65.066
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.087 0 0 0 0 0 0 232 100 313 280 95 67
2020/20212.120 52 107 202 68 227 141 92 118 249 178 503 183
2021/20223.366 220 102 142 144 231 556 629 169 190 249 292 442
2022/20233.110 398 254 265 351 298 549 89 397 229 55 142 83
2023/20241.933 62 158 84 86 412 175 129 150 83 130 223 241
2024/20251.945 171 411 201 433 411 269 49 0 0 0 0 0
Totale 23.066