IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

DE AMICI, MARCO
 Distribuzione geografica
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Continente #
EU - Europa 13.144
NA - Nord America 10.226
AS - Asia 9.909
SA - Sud America 891
AF - Africa 221
OC - Oceania 90
Continente sconosciuto - Info sul continente non disponibili 12
Totale 34.493
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Nazione #
US - Stati Uniti d'America 9.921
GB - Regno Unito 3.442
SG - Singapore 2.883
CN - Cina 2.724
IT - Italia 2.289
DE - Germania 2.254
RU - Federazione Russa 1.379
SE - Svezia 1.233
HK - Hong Kong 1.110
IN - India 661
BR - Brasile 632
FR - Francia 610
VN - Vietnam 568
TR - Turchia 439
KR - Corea 400
NL - Olanda 331
IE - Irlanda 328
BD - Bangladesh 319
UA - Ucraina 304
FI - Finlandia 271
JP - Giappone 213
CA - Canada 183
EU - Europa 148
ES - Italia 147
ID - Indonesia 136
DK - Danimarca 100
AU - Australia 86
PH - Filippine 79
CO - Colombia 78
GR - Grecia 66
MX - Messico 65
AR - Argentina 62
PK - Pakistan 59
AT - Austria 56
PL - Polonia 53
BE - Belgio 48
CI - Costa d'Avorio 48
CH - Svizzera 45
ZA - Sudafrica 41
IQ - Iraq 39
IR - Iran 38
TW - Taiwan 37
CL - Cile 35
EC - Ecuador 34
RO - Romania 29
SA - Arabia Saudita 29
LV - Lettonia 25
MA - Marocco 24
MY - Malesia 23
IL - Israele 22
UZ - Uzbekistan 22
EG - Egitto 20
TH - Thailandia 20
KE - Kenya 17
TN - Tunisia 17
NO - Norvegia 16
CZ - Repubblica Ceca 14
DZ - Algeria 14
JO - Giordania 13
PE - Perù 13
VE - Venezuela 13
AE - Emirati Arabi Uniti 12
AL - Albania 12
JM - Giamaica 12
PT - Portogallo 12
BY - Bielorussia 11
HU - Ungheria 11
NP - Nepal 11
UY - Uruguay 11
AZ - Azerbaigian 10
PR - Porto Rico 10
LU - Lussemburgo 9
RS - Serbia 9
ET - Etiopia 8
HN - Honduras 8
PY - Paraguay 8
HR - Croazia 7
CM - Camerun 6
NG - Nigeria 6
BG - Bulgaria 5
BH - Bahrain 5
BO - Bolivia 5
DO - Repubblica Dominicana 5
KG - Kirghizistan 5
LT - Lituania 5
SC - Seychelles 5
BA - Bosnia-Erzegovina 4
CR - Costa Rica 4
GT - Guatemala 4
MD - Moldavia 4
OM - Oman 4
SK - Slovacchia (Repubblica Slovacca) 4
BB - Barbados 3
EE - Estonia 3
GA - Gabon 3
LK - Sri Lanka 3
MM - Myanmar 3
NZ - Nuova Zelanda 3
PA - Panama 3
PS - Palestinian Territory 3
Totale 34.581
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Città #
Southend 3.092
Singapore 1.640
Hanover 981
Ashburn 901
Hong Kong 812
San Jose 788
Chandler 708
Milan 680
Beijing 563
Seattle 526
Dallas 468
Council Bluffs 433
Princeton 419
Wilmington 331
Dublin 319
Munich 284
Santa Clara 264
Los Angeles 262
Ann Arbor 244
Mountain View 220
Redmond 215
Hefei 195
Lauterbourg 181
Bengaluru 176
Ho Chi Minh City 172
Dearborn 167
New York 159
Jacksonville 155
Nanjing 154
Moscow 149
Buffalo 144
Boardman 138
Hanoi 138
Fairfield 131
Rome 131
Des Moines 129
Woodbridge 128
Sakarya 117
Tokyo 113
Berlin 110
Houston 109
Frankfurt am Main 107
Guangzhou 105
Shanghai 105
Jinan 85
Somerville 80
Jakarta 77
The Dalles 74
Shenyang 72
Seoul 70
Serra 70
Columbus 65
Tianjin 65
Toronto 64
Athens 63
Redwood City 63
São Paulo 63
Barcelona 62
Helsinki 62
Cambridge 61
Andover 60
Bogotá 60
Cangzhou 60
Istanbul 52
Medford 52
Würzburg 49
Abidjan 48
Mumbai 47
Nanchang 46
Changsha 45
Hebei 44
San Diego 44
Sunnyvale 40
Naples 39
Nuremberg 39
Phoenix 39
London 38
Amsterdam 37
Atlanta 35
Brussels 35
Orem 35
Eitensheim 34
Zhengzhou 33
Hangzhou 32
Stockholm 32
Chicago 30
Ningbo 30
Melbourne 29
Bühl 28
Denver 28
Florence 28
Kunming 28
Shenzhen 28
Bitonto 27
Grafing 26
Montreal 26
Turin 26
Brescia 24
Chennai 24
Kyiv 24
Totale 19.940
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Nome #
Agonisti nicotinici selettivi nel trattamento di patologie del Sistema Nervoso Centrale 598
Epiboxidine and Novel Related Analogues : a Convenient Synthetic Approach and Estimation of Their Affinity at Neuronal Nicotinic Acetylcholine Receptor Subtypes 517
Advances in small molecule selective ligands for heteromeric nicotinic acetylcholine receptors 445
Combined treatments with the dualsteric agonist N-8-Iper plus chemotherapy drugs affect drug resistance in glioblastoma cancer stem cells 438
Agenti Adrenergici 406
Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes 366
A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitors 316
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype [Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the alpha 3 beta 4 nicotinic acetylcholine receptor subtype] 311
2020 Italian special anniversary collection : Celebrating NMMC 2019 and 40 Years of the DCF-SCI 303
The Mechanisms Mediated by α7 Acetylcholine Nicotinic Receptors May Contribute to Peripheral Nerve Regeneration 299
Selective agonists for M2 muscarinic receptors inhibit cell proliferation and survival in human glioblastoma cells: Possible implications in drug resistance 291
Synthesis and pharmacological characterization at glutamate receptors of erythro- and threo-tricholomic acid and homologues thereof 281
Photoswitchable ligands for the optical control of α7 nicotinic acetylcholine receptors: synthesis and photochromic characterization 280
New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus: Synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations 274
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling 267
Synthesis and characterization of 13C labeled carnosine derivatives for isotope dilution mass spectrometry measurements in biological matrices 264
Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors 258
Orthosteric and allosteric ligands selectively acting at cholinergic receptor subtypes 254
Synthesis of epibatidine-related Delta(2)-isoxazoline derivatives and evaluation of their binding affinity at neuronal nicotinic acetylcholine receptors 250
Novel pharmacological tools which activate mAChRs: a question of "dualsterism" 250
Synthesis and structure-activity relationships in a set of new antimuscarinic agents 249
Design, Synthesis, and Pharmacological Characterization of Novel Spirocyclic Quinuclidinyl-Δ2-Isoxazoline Derivatives as Potent and Selective Agonists of α7 Nicotinic Acetylcholine Receptors 243
Gaucher Disease: A Glance from a Medicinal Chemistry Perspective 242
Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake 242
Synthesis and application of isotope-labeled carnosine in LCMS/MS 242
Dualsteric compounds modulate the signaling pattern of muscarinic M1 acetylcholine receptors 239
The novel hybrid agonist HyNDA-1 targets the D3R-nAChR heteromeric complex in dopaminergic neurons 238
Iperoxo/dequalinium and W84/dequalinium hybrid ligands: synthesis, pharmacological and computational investigation at M2 mAChRs 236
Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes 234
Novel ligands for neuronal nicotinic receptor subtypes: synthetic, pharmacological and molecular docking studies 232
Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters 229
Interaction between M2 Muscarinic receptors and β-1 arrestin in gliblastoma cell lines: effects mediated by orthosteric and dualsteric agonists 224
The impact of Chirality on Medicinal Chemistry 224
Synthesis, Binding Affinity at Glutamic Acid Receptors, Neuroprotective Effects, and Molecular Modeling Investigation of Novel Dihydroisoxazole Amino Acids 223
Allosteric modulation of alpha7 nicotinic receptors : mechanistic insight through metadynamics and essential dynamics 222
Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation 220
Synthesis and binding affinity at α4β2 and α7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system 218
Design and synthesis of selective ligands targeting different nAChR subtypes 218
Optical control of dopamine receptors in vitro and in vivo with photoswitchable ligands 216
Design of Cyclopentaisoxazoline Amino Acids as Conformationally Constrained Agonists at Glutamate Receptors 214
Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: Synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity 213
Determination of acid dissociation constants of compounds active at neuronal nicotinic acetylcholine receptors by means of electrophoretic and potentiometric techniques 213
(Trans)dermal delivery of opioids: a structure-permeability relationship 213
The enantiomers of epiboxidine and of two related analogs: Synthesis and estimation of their binding affinity at α4β2 and α7 neuronal nicotinic acetylcholine receptors 213
Synthesis and Anticonvulsant Activity of Novel Bicyclic Acidic Amino Acids 212
Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors 212
Determination of acid dissociation constants of poorly water-soluble nicotinic ligands by means of electrophoretic and potentiometric techniques 211
New spirocyclic Δ2-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors 210
Alpha7 nAChR: pathogenesis and treatment of chemotherapy-induced neuropathy 210
Identification of novel potential B4GALT6 inhibitors through a large scale virtual screening 207
Novel Analgesic Agents Obtained by Molecular Hybridization of Orthosteric and Allosteric Ligands 207
Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization 206
Synthesis and biological evaluation of new amino acids structurally related to the antitumor agent acivicin 205
In silico design of agonists targeting the alpha7 nicotinic acetylcholine receptors, their synthesis and preliminary pharmacological evaluation 205
Nuovi ligandi nicotinici correlati all'Epibatidina e all'Epibossidina: sintesi e valutazione della loro affinità per i recettori nicotinici neuronali alpha4beta2 e alpha7 205
Epiboxidine and Novel-Related Analogues: A Convenient Synthetic Approach and Estimation of Their at Neuronal Nicotinic Acetylcholine Receptor Subtypes 204
Design, synthesis and preliminary biological evaluation of 3-cyclopropyl-4-phenoxy-1H-pyrazole derivatives as small molecular ligands of RAGE 204
Alpha7 nicotinic acetylcholine receptor agonists: prediction of their binding affinity through a molecular mechanics poisson-boltzmann surface area approach 201
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid 201
Chemotherapy-induced neuropathy: involvement of the alpha7 nAChR subtype 201
The enantiomers of epiboxidine: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes 200
Peptide derivatives and therapeutic activity thereof 200
Allosteric ligands for G protein-coupled receptors : a novel strategy with attractive therapeutic opportunities 199
Tacrine/Xanomeline hybrid ligands: synthesis and pharmacological evaluation at M1 muscarinic acetylcholine receptors and acetylcholinesterases 199
Design of novel α7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies 196
Analgesic effects mediated by muscarinic ligands acting at both orthosteric and allosteric receptor binding sites 191
Photoswitchable ligands for light-mediated control of α7 nicotinic acetylcholine receptors: design, synthesis and photochromic characterization 190
Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-Coupled Receptor 189
Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light 188
Nicotinic anti-inflammatory pathway: a new target to control low-grade inflammation and glucose homeostasis in obesity 187
Activation of M2 muscarinic acetylcholine receptors by orthosteric and dualsteric agonists in glioblastoma cancer stem cells: effects on cell proliferation and drug resistance 187
A Combinatorial Biocatalysis Approach to an Array of Cholic Acid Derivatives 185
Synthesis of enantiopure Delta(2)-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes 184
Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor 183
Synthesis of pyrrol-3-yl-ethanolamines 179
Dualsteric activation of M2 muscarinic acetylcholine receptors inhibits cell proliferation in human glioblastoma cell lines 179
Synthesis of novel enantiopure 2-isoxazoline and 2-pyrazoline amino acids and their activity at glutamic acid receptors and transporters 178
Synthesis of new Delta(2)-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists 178
Design of Novel Conformationally Restricted Analogues of Glutamic Acid 177
Synthesis of novel epibatidine-related derivatives through 1,3-dipolar cycloaddition of pyridinenitrile oxides 176
A new synthesis of (D,L)-muscarone via 1,3-dipolar cycloaddition 176
Development of a Three-Dimensional Model for the N-Methyl-D-aspartate NR2A Subunit 172
Synthesis and pharmacological characterization of new analogs of broxaterol 172
Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists 171
Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation 171
G protein inhibitors unravel Gq-dependent adenylyl cyclase activation in CHO-M1 cells 171
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF THE 3-ANALOGS OF VIMINOL 170
Novel bicylic delta2-isoxazoline and 3-oxo-isoxazolidine derivatives : synthesis and binding affinity at neuronal nicotinic receptor subtypes 170
Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human b-adrenergic receptor subtypes 169
The Combined Treatment with Chemotherapeutic Agents and the Dualsteric Muscarinic Agonist Iper-8-Naphthalimide Affects Drug Resistance in Glioblastoma Stem Cells 168
Nicotinic agonists selective for the Alpha7 Receptor Subtype, the process for their preparation thereof and pharmaceutical compositions therefrom 167
Activation of M2 muscarinic acetylcholine receptors by a hybrid agonist enhances cytotoxic effects in GB7 glioblastoma cancer stem cells 167
Modulation of bacterial cell adhesion proteins via photoswitchable ligand: a promising strategy to counteract biofilm formation 166
M2-Receptor Stimulation in Blood-Brain-Tumour Barrier: Implications in Glioblastoma Therapy 163
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF STEREOISOMERIC MUSCARINES 163
Progettazione e sintesi di analoghi strutturali dell’Epibossodina 161
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF CHOLINERGIC LIGANDS STRUCTURALLY RELATED TO MUSCARONE 161
Relative potencies of the stereoisomers of bethanechol on muscarinic receptor 161
New hybrid muscarinic agonists: in vitro functional characterization and in vivo analgesic activity evaluation 160
METAL-HYDRIDE REDUCTION OF ISOXAZOLINE-3-CARBOXYLATE ESTERS 160
Totale 22.510
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Categoria #
all - tutte 95.264
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 95.264
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021686 0 0 0 0 0 0 0 0 0 0 503 183
2021/20223.366 220 102 142 144 231 556 629 169 190 249 292 442
2022/20233.110 398 254 265 351 298 549 89 397 229 55 142 83
2023/20241.933 62 158 84 86 412 175 129 150 83 130 223 241
2024/20254.821 171 411 174 429 401 214 162 584 228 346 699 1.002
2025/202610.511 943 688 1.358 952 1.030 798 1.229 607 1.224 795 887 0
Totale 36.453