DE AMICI, MARCO
 Distribuzione geografica
Continente #
EU - Europa 10.335
NA - Nord America 5.502
AS - Asia 2.984
SA - Sud America 94
OC - Oceania 36
AF - Africa 32
Continente sconosciuto - Info sul continente non disponibili 10
Totale 18.993
Nazione #
US - Stati Uniti d'America 5.399
GB - Regno Unito 3.326
DE - Germania 2.170
IT - Italia 1.388
SE - Svezia 1.196
CN - Cina 1.160
RU - Federazione Russa 603
IN - India 441
TR - Turchia 392
HK - Hong Kong 337
KR - Corea 323
IE - Irlanda 314
FR - Francia 288
UA - Ucraina 263
FI - Finlandia 187
NL - Olanda 152
EU - Europa 148
DK - Danimarca 94
ES - Italia 92
CA - Canada 83
BE - Belgio 78
JP - Giappone 72
GR - Grecia 62
PH - Filippine 57
CO - Colombia 56
SG - Singapore 43
ID - Indonesia 37
AU - Australia 34
VN - Vietnam 33
IR - Iran 28
CH - Svizzera 26
BR - Brasile 22
RO - Romania 20
PL - Polonia 18
MX - Messico 17
PK - Pakistan 14
IL - Israele 11
CZ - Repubblica Ceca 10
NO - Norvegia 10
TW - Taiwan 8
CL - Cile 7
MA - Marocco 7
TN - Tunisia 7
AT - Austria 6
HU - Ungheria 6
NG - Nigeria 6
RS - Serbia 6
TH - Thailandia 6
MY - Malesia 5
HR - Croazia 4
PT - Portogallo 4
SC - Seychelles 4
AR - Argentina 3
BG - Bulgaria 3
EC - Ecuador 3
JO - Giordania 3
UZ - Uzbekistan 3
ZA - Sudafrica 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AE - Emirati Arabi Uniti 2
BY - Bielorussia 2
HN - Honduras 2
IQ - Iraq 2
IS - Islanda 2
KZ - Kazakistan 2
NZ - Nuova Zelanda 2
PE - Perù 2
SK - Slovacchia (Repubblica Slovacca) 2
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BD - Bangladesh 1
CM - Camerun 1
CR - Costa Rica 1
DZ - Algeria 1
EG - Egitto 1
ET - Etiopia 1
LV - Lettonia 1
MM - Myanmar 1
MN - Mongolia 1
MT - Malta 1
SA - Arabia Saudita 1
UY - Uruguay 1
ZW - Zimbabwe 1
Totale 19.133
Città #
Southend 3.092
Hanover 981
Chandler 707
Seattle 517
Milan 478
Princeton 419
Wilmington 330
Dublin 305
Beijing 266
Munich 252
Ann Arbor 244
Frankfurt am Main 231
Ashburn 221
Mountain View 220
Redmond 215
Dearborn 167
Jacksonville 154
Nanjing 150
Fairfield 129
Woodbridge 127
Des Moines 126
Sakarya 117
Boardman 104
Berlin 101
Bengaluru 100
Houston 99
Hong Kong 97
Jinan 80
Somerville 80
Brussels 70
Serra 70
Shenyang 69
Redwood City 63
Cambridge 61
Andover 60
Athens 60
Barcelona 58
Bogotá 54
Medford 51
Würzburg 49
Rome 48
Toronto 48
Hebei 44
Nanchang 44
Sunnyvale 40
New York 38
Istanbul 37
Shanghai 37
Changsha 36
San Diego 36
Tianjin 35
Ningbo 29
Bitonto 27
Mumbai 27
Grafing 26
Guangzhou 26
Kunming 24
London 24
Zhengzhou 24
Hamburg 21
Hangzhou 21
Hefei 19
Los Angeles 19
Dong Ket 18
Jiaxing 17
Norwalk 17
Phoenix 17
Seoul 17
Helsinki 16
Seongnam 16
Auburn Hills 15
Falls Church 15
Tokyo 15
Haikou 14
Nürnberg 14
Tappahannock 14
Boston 13
Chicago 13
Pune 13
Turin 13
Florence 12
Ottawa 12
Siracusa 12
Brescia 11
Mannheim 11
Rho 11
Taizhou 11
Varedo 11
Verona 11
Zurich 11
Gainesville 10
São Paulo 10
Taiyuan 10
Cinisello Balsamo 9
Dallas 9
Lanzhou 9
Odernheim 9
Perugia 9
Wuhan 9
Denver 8
Totale 11.966
Nome #
Epiboxidine and Novel Related Analogues : a Convenient Synthetic Approach and Estimation of Their Affinity at Neuronal Nicotinic Acetylcholine Receptor Subtypes 354
Agenti Adrenergici 339
Agonisti nicotinici selettivi nel trattamento di patologie del Sistema Nervoso Centrale 285
Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes 268
Combined treatments with the dualsteric agonist N-8-Iper plus chemotherapy drugs affect drug resistance in glioblastoma cancer stem cells 251
2020 Italian special anniversary collection : Celebrating NMMC 2019 and 40 Years of the DCF-SCI 213
Synthesis and pharmacological characterization at glutamate receptors of erythro- and threo-tricholomic acid and homologues thereof 212
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling 206
The Mechanisms Mediated by α7 Acetylcholine Nicotinic Receptors May Contribute to Peripheral Nerve Regeneration 202
New analogues of epiboxidine incorporating the 4,5-dihydroisoxazole nucleus: Synthesis, binding affinity at neuronal nicotinic acetylcholine receptors, and molecular modeling investigations 184
The impact of Chirality on Medicinal Chemistry 173
Selective agonists for M2 muscarinic receptors inhibit cell proliferation and survival in human glioblastoma cells: Possible implications in drug resistance 172
Synthesis and structure-activity relationships in a set of new antimuscarinic agents 171
(Trans)dermal delivery of opioids: a structure-permeability relationship 165
Photoswitchable ligands for the optical control of α7 nicotinic acetylcholine receptors: synthesis and photochromic characterization 158
Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes 153
Chemotherapy-induced neuropathy: involvement of the alpha7 nAChR subtype 153
Novel pharmacological tools which activate mAChRs: a question of "dualsterism" 153
Allosteric ligands for G protein-coupled receptors : a novel strategy with attractive therapeutic opportunities 152
Design of Cyclopentaisoxazoline Amino Acids as Conformationally Constrained Agonists at Glutamate Receptors 151
In silico design of agonists targeting the alpha7 nicotinic acetylcholine receptors, their synthesis and preliminary pharmacological evaluation 150
Synthesis, Binding Affinity at Glutamic Acid Receptors, Neuroprotective Effects, and Molecular Modeling Investigation of Novel Dihydroisoxazole Amino Acids 149
Alpha7 nicotinic acetylcholine receptor agonists: prediction of their binding affinity through a molecular mechanics poisson-boltzmann surface area approach 147
Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters 147
Synthesis of epibatidine-related Delta(2)-isoxazoline derivatives and evaluation of their binding affinity at neuronal nicotinic acetylcholine receptors 147
Novel ligands for neuronal nicotinic receptor subtypes: synthetic, pharmacological and molecular docking studies 144
Alpha7 nAChR: pathogenesis and treatment of chemotherapy-induced neuropathy 144
Orthosteric and allosteric ligands selectively acting at cholinergic receptor subtypes 142
Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake 138
Design and synthesis of selective ligands targeting different nAChR subtypes 138
A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitors 137
Design, Synthesis, and Pharmacological Characterization of Novel Spirocyclic Quinuclidinyl-Δ2-Isoxazoline Derivatives as Potent and Selective Agonists of α7 Nicotinic Acetylcholine Receptors 136
Synthesis and Anticonvulsant Activity of Novel Bicyclic Acidic Amino Acids 135
Determination of acid dissociation constants of compounds active at neuronal nicotinic acetylcholine receptors by means of electrophoretic and potentiometric techniques 135
Synthesis and biological evaluation of new amino acids structurally related to the antitumor agent acivicin 134
Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-Coupled Receptor 130
A new synthesis of (D,L)-muscarone via 1,3-dipolar cycloaddition 129
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid 128
Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: Synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity 128
Activation of M2 muscarinic acetylcholine receptors by orthosteric and dualsteric agonists in glioblastoma cancer stem cells: effects on cell proliferation and drug resistance 128
A Combinatorial Biocatalysis Approach to an Array of Cholic Acid Derivatives 124
Synthesis of enantiopure Delta(2)-isoxazoline derivatives and evaluation of their affinity and efficacy profiles at human beta-adrenergic receptor subtypes 124
Synthesis of new Delta(2)-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists 124
Synthesis of pyrrol-3-yl-ethanolamines 123
The enantiomers of epiboxidine: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes 122
Synthesis and pharmacological characterization of new analogs of broxaterol 122
Novel Analgesic Agents Obtained by Molecular Hybridization of Orthosteric and Allosteric Ligands 122
New spirocyclic Δ2-isoxazoline derivatives related to selective agonists of α7 neuronal nicotinic acetylcholine receptors 121
Dualsteric compounds modulate the signaling pattern of muscarinic M1 acetylcholine receptors 121
Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors 121
Nicotinic agonists selective for the Alpha7 Receptor Subtype, the process for their preparation thereof and pharmaceutical compositions therefrom 118
Analgesic effects mediated by muscarinic ligands acting at both orthosteric and allosteric receptor binding sites 118
Determination of acid dissociation constants of poorly water-soluble nicotinic ligands by means of electrophoretic and potentiometric techniques 118
Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor 117
Allosteric modulation of alpha7 nicotinic receptors : mechanistic insight through metadynamics and essential dynamics 117
New hybrid muscarinic agonists: in vitro functional characterization and in vivo analgesic activity evaluation 116
Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors 116
AN EASY SYNTHESIS OF DIHYDROMUSCIMOL 116
Design, synthesis and pharmacological properties of alkylbisammonio bitopic ligands of muscarinic acetylcholine receptors 116
Peptide derivatives and therapeutic activity thereof 116
Design of Novel Conformationally Restricted Analogues of Glutamic Acid 114
Progettazione e sintesi di analoghi strutturali dell’Epibossodina 114
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF THE 3-ANALOGS OF VIMINOL 114
Design of novel α7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies 113
Nuovi ligandi nicotinici correlati all'Epibatidina e all'Epibossidina: sintesi e valutazione della loro affinità per i recettori nicotinici neuronali alpha4beta2 e alpha7 113
Photoswitchable ligands for light-mediated control of α7 nicotinic acetylcholine receptors: design, synthesis and photochromic characterization 113
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype [Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the alpha 3 beta 4 nicotinic acetylcholine receptor subtype] 112
Nicotinic anti-inflammatory pathway: a new target to control low-grade inflammation and glucose homeostasis in obesity 112
Activation of M2 muscarinic acetylcholine receptors by a hybrid agonist enhances cytotoxic effects in GB7 glioblastoma cancer stem cells 111
Synthesis and application of isotope-labeled carnosine in LCMS/MS 111
Development of a Three-Dimensional Model for the N-Methyl-D-aspartate NR2A Subunit 110
Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization 110
beta(3)-adrenergic receptor ligands: insight into structure-activity relationships using Monte-Carlo conformational analysis in water 109
METAL-HYDRIDE REDUCTION OF ISOXAZOLINE-3-CARBOXYLATE ESTERS 108
Synthesis of 3-benzenesulfonylisoxazolines and isoxazolidines 108
A chemoenzymatic approach to the synthesis of the stereoisomers of a beta-adrenergic receptor antagonist 107
AN EFFICIENT SYNTHESIS OF ISOXAZOLES AND ISOXAZOLINES 107
Synthesis and characterization of 13C labeled carnosine derivatives for isotope dilution mass spectrometry measurements in biological matrices 107
The novel hybrid agonist HyNDA-1 targets the D3R-nAChR heteromeric complex in dopaminergic neurons 106
Dualsteric activation of M2 muscarinic acetylcholine receptors inhibits cell proliferation in human glioblastoma cell lines 106
Novel bicylic delta2-isoxazoline and 3-oxo-isoxazolidine derivatives : synthesis and binding affinity at neuronal nicotinic receptor subtypes 105
The enantiomers of epiboxidine and of two related analogs: Synthesis and estimation of their binding affinity at α4β2 and α7 neuronal nicotinic acetylcholine receptors 105
Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation 105
Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists 104
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF CHOLINERGIC LIGANDS STRUCTURALLY RELATED TO MUSCARONE 104
Chemoenzymatic synthesis of the enantiomers of desoxymuscarine 104
Epiboxidine and Novel-Related Analogues: A Convenient Synthetic Approach and Estimation of Their at Neuronal Nicotinic Acetylcholine Receptor Subtypes 104
Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation 104
The Combined Treatment with Chemotherapeutic Agents and the Dualsteric Muscarinic Agonist Iper-8-Naphthalimide Affects Drug Resistance in Glioblastoma Stem Cells 104
Synthesis of novel epibatidine-related derivatives through 1,3-dipolar cycloaddition of pyridinenitrile oxides 103
Synthesis of novel enantiopure 2-isoxazoline and 2-pyrazoline amino acids and their activity at glutamic acid receptors and transporters 103
SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF STEREOISOMERIC MUSCARINES 103
Selective nicotinic agonists to treat pathologies of the central nervous system 103
Allosteric modulators and selective agonists of muscarinic receptors 101
Synthesis and binding affinity of new muscarinic ligands structurally related to oxotremorine 101
SYNTHESIS, BIOLOGICAL-ACTIVITY AND CONFORMATIONAL-ANALYSIS OF SOME ACYCLIC CHOLINERGIC LIGANDS 101
Relative potencies of the stereoisomers of bethanechol on muscarinic receptor 101
Tacrine/Xanomeline hybrid ligands: synthesis and pharmacological evaluation at M1 muscarinic acetylcholine receptors and acetylcholinesterases 101
Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors 100
ANALOGS OF THE LOW-EFFICACY PARTIAL GABA-A AGONIST 4-PIOL - SYNTHESES AND INVITRO PHARMACOLOGICAL STUDIES 97
Totale 13.531
Categoria #
all - tutte 43.325
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 43.325


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019501 0 0 0 0 0 0 0 36 169 51 150 95
2019/20202.023 351 114 100 86 103 182 232 100 313 280 95 67
2020/20212.120 52 107 202 68 227 141 92 118 249 178 503 183
2021/20223.366 220 102 142 144 231 556 629 169 190 249 292 442
2022/20233.138 398 254 265 351 298 549 93 401 237 56 148 88
2023/20241.429 77 162 108 127 549 175 129 102 0 0 0 0
Totale 20.645