A series of isoxazole derivatives structurally related to broxaterol 1 has been prepared and tested for their potency to β1 and β2 adrenergic receptors. At variance with broxaterol, none of the tested compounds displayed agonistic activity. The 3-isopropenyl derivative 5f is the most potent antagonist both in the trachea and atria preparations.

Synthesis and pharmacological characterization of new analogs of broxaterol / M. De Amici, P. Conti, C. Dallanoce, L. Kassi, S. Castellano, G. Stefancich, C. De Micheli. - In: MEDICINAL CHEMISTRY RESEARCH. - ISSN 1054-2523. - 10:2(2000), pp. 69-80.

Synthesis and pharmacological characterization of new analogs of broxaterol

M. De Amici;P. Conti;C. Dallanoce;C. De Micheli
2000

Abstract

A series of isoxazole derivatives structurally related to broxaterol 1 has been prepared and tested for their potency to β1 and β2 adrenergic receptors. At variance with broxaterol, none of the tested compounds displayed agonistic activity. The 3-isopropenyl derivative 5f is the most potent antagonist both in the trachea and atria preparations.
Settore CHIM/08 - Chimica Farmaceutica
MEDICINAL CHEMISTRY RESEARCH
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/183407
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