| Nome |
# |
|
Orthosteric and allosteric ligands selectively acting at cholinergic receptor subtypes, file dfa8b991-90ca-748b-e053-3a05fe0a3a96
|
2.639
|
|
Selective agonists for M2 muscarinic receptors inhibit cell proliferation and survival in human glioblastoma cells: Possible implications in drug resistance, file dfa8b992-92ff-748b-e053-3a05fe0a3a96
|
964
|
|
Epiboxidine and Novel Related Analogues : a Convenient Synthetic Approach and Estimation of Their Affinity at Neuronal Nicotinic Acetylcholine Receptor Subtypes, file dfa8b98e-dddd-748b-e053-3a05fe0a3a96
|
517
|
|
Combined treatments with the dualsteric agonist N-8-Iper plus chemotherapy drugs affect drug resistance in glioblastoma cancer stem cells, file dfa8b9a8-2737-748b-e053-3a05fe0a3a96
|
504
|
|
Nicotinic anti-inflammatory pathway: a new target to control low-grade inflammation and glucose homeostasis in obesity, file dfa8b995-3b93-748b-e053-3a05fe0a3a96
|
373
|
|
The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling, file dfa8b994-15aa-748b-e053-3a05fe0a3a96
|
195
|
|
Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-Coupled Receptor, file dfa8b999-d9d2-748b-e053-3a05fe0a3a96
|
167
|
|
Photoswitchable ligands for the optical control of α7 nicotinic acetylcholine receptors: synthesis and photochromic characterization, file dfa8b9a7-5d07-748b-e053-3a05fe0a3a96
|
151
|
|
Determination of acid dissociation constants of compounds active at neuronal nicotinic acetylcholine receptors by means of electrophoretic and potentiometric techniques, file dfa8b995-622a-748b-e053-3a05fe0a3a96
|
148
|
|
2020 Italian special anniversary collection : Celebrating NMMC 2019 and 40 Years of the DCF-SCI, file dfa8b9a5-0c18-748b-e053-3a05fe0a3a96
|
140
|
|
Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors, file dfa8b9a4-dbf8-748b-e053-3a05fe0a3a96
|
132
|
|
Synthesis of a group of novel Xanomeline/77-LH-28-1 hybrid ligands and their FRET investigation at muscarinic acetylcholine receptor subtypes, file dfa8b999-240e-748b-e053-3a05fe0a3a96
|
126
|
|
Synthesis and characterization of 13C labeled carnosine derivatives for isotope dilution mass spectrometry measurements in biological matrices, file dfa8b9a8-d8eb-748b-e053-3a05fe0a3a96
|
120
|
|
Dualsteric activation of M2 muscarinic acetylcholine receptors inhibits cell proliferation in human glioblastoma cell lines, file dfa8b991-599e-748b-e053-3a05fe0a3a96
|
111
|
|
Determination of acid dissociation constants of poorly water-soluble nicotinic ligands by means of electrophoretic and potentiometric techniques, file dfa8b993-0586-748b-e053-3a05fe0a3a96
|
79
|
|
Advances in small molecule selective ligands for heteromeric nicotinic acetylcholine receptors, file df42ed82-6638-4c14-8151-0f583ddb279c
|
76
|
|
The novel hybrid agonist HyNDA-1 targets the D3R-nAChR heteromeric complex in dopaminergic neurons, file dbee64ef-8541-4323-89d0-55f553f2df81
|
68
|
|
Novel Bifunctional Compounds Targeting Nicotine and Dopamine Receptor Subtypes: Synthesis and Pharmacological Investigation, file dfa8b990-dbce-748b-e053-3a05fe0a3a96
|
66
|
|
A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitors, file 507096be-a404-487c-8269-efc794fe5f7f
|
58
|
|
Novel Analgesic Agents Obtained by Molecular Hybridization of Orthosteric and Allosteric Ligands, file dfa8b9a3-afcf-748b-e053-3a05fe0a3a96
|
58
|
|
Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation, file dfa8b9a5-26aa-748b-e053-3a05fe0a3a96
|
54
|
|
A Small Library of 1,2,3-Triazole Analogs of CAP-55: Synthesis and Binding Affinity at Nicotinic Acetylcholine Receptors, file cd5e51cb-f745-42cf-9929-fc1081106f25
|
52
|
|
The Combined Treatment with Chemotherapeutic Agents and the Dualsteric Muscarinic Agonist Iper-8-Naphthalimide Affects Drug Resistance in Glioblastoma Stem Cells, file dfa8b9a7-a4b3-748b-e053-3a05fe0a3a96
|
51
|
|
Iperoxo/dequalinium and W84/dequalinium hybrid ligands: synthesis, pharmacological and computational investigation at M2 mAChRs, file aa0bb1db-285b-476a-afcd-0ab2b99bb1d9
|
47
|
|
Peptide derivatives and therapeutic activity thereof, file dfa8b99f-f3b5-748b-e053-3a05fe0a3a96
|
47
|
|
The Mechanisms Mediated by α7 Acetylcholine Nicotinic Receptors May Contribute to Peripheral Nerve Regeneration, file dfa8b9a8-e64d-748b-e053-3a05fe0a3a96
|
40
|
|
Novel pharmacological tools which activate mAChRs: a question of "dualsterism", file dfa8b991-2353-748b-e053-3a05fe0a3a96
|
38
|
|
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype [Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the alpha 3 beta 4 nicotinic acetylcholine receptor subtype], file 4dc6b9c2-6da3-4a3e-b6b4-0f30a60be95c
|
37
|
|
2020 Italian special anniversary collection : Celebrating NMMC 2019 and 40 Years of the DCF-SCI, file dfa8b9a4-bf25-748b-e053-3a05fe0a3a96
|
32
|
|
Design and synthesis of selective ligands targeting different nAChR subtypes, file dfa8b991-1779-748b-e053-3a05fe0a3a96
|
30
|
|
2020 Italian special anniversary collection : Celebrating NMMC 2019 and 40 Years of the DCF-SCI, file dfa8b9a5-6595-748b-e053-3a05fe0a3a96
|
30
|
|
Dualsteric compounds modulate the signaling pattern of muscarinic M1 acetylcholine receptors, file dfa8b995-9430-748b-e053-3a05fe0a3a96
|
27
|
|
Ligand-Specific Allosteric Coupling Controls G-Protein-Coupled Receptor Signaling, file dfa8b9a5-26a8-748b-e053-3a05fe0a3a96
|
26
|
|
α7 Nicotinic Acetylcholine Receptors May Improve Schwann Cell Regenerating Potential via Metabotropic Signaling Pathways, file 2ac7d1e2-97b0-49c1-8bb6-50c3b8efce7a
|
25
|
|
Optical control of dopamine receptors in vitro and in vivo with photoswitchable ligands, file 31790261-5162-4bb1-8d0e-32d4f40867e5
|
19
|
|
Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation, file dfa8b9a3-b42f-748b-e053-3a05fe0a3a96
|
19
|
|
Design, synthesis and preliminary biological evaluation of 3-cyclopropyl-4-phenoxy-1H-pyrazole derivatives as small molecular ligands of RAGE, file dfa8b99f-f44c-748b-e053-3a05fe0a3a96
|
18
|
|
Synthesis and application of isotope-labeled carnosine in LCMS/MS, file dfa8b9a0-17ef-748b-e053-3a05fe0a3a96
|
18
|
|
Novel Xanomeline-Containing Bitopic Ligands of Muscarinic Acetylcholine Receptors: Design, Synthesis and FRET Investigation, file 8e062129-dc74-44ea-9215-7e1da4cc8724
|
17
|
|
Muscarinic dualsteric ligands behave as partial or protean agonists depending on the affinity of their orthosteric moiety, file dfa8b993-4f9f-748b-e053-3a05fe0a3a96
|
15
|
|
Novel Bifunctional Compounds Targeting Nicotine and Dopamine Receptor Subtypes: Synthesis and Pharmacological Investigation, file dfa8b990-dbcf-748b-e053-3a05fe0a3a96
|
14
|
|
Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M1 and M2, file dfa8b999-5155-748b-e053-3a05fe0a3a96
|
10
|
|
The novel hybrid agonist HyNDA-1 targets the D3R-nAChR heteromeric complex in dopaminergic neurons, file dfa8b99f-8e82-748b-e053-3a05fe0a3a96
|
10
|
|
Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors, file dfa8b9a1-7b3e-748b-e053-3a05fe0a3a96
|
10
|
|
In vivo and in vitro ADMET profiling and in vivo pharmacodynamic investigations of a selective α7 nicotinic acetylcholine receptor agonist with a spirocyclic Δ2-isoxazoline molecular skeleton, file dfa8b99a-0959-748b-e053-3a05fe0a3a96
|
9
|
|
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype [Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the alpha 3 beta 4 nicotinic acetylcholine receptor subtype], file dfa8b994-35ba-748b-e053-3a05fe0a3a96
|
8
|
|
Design, Synthesis, and Pharmacological Characterization of Novel Spirocyclic Quinuclidinyl-Δ2-Isoxazoline Derivatives as Potent and Selective Agonists of α7 Nicotinic Acetylcholine Receptors, file dfa8b994-3b46-748b-e053-3a05fe0a3a96
|
7
|
|
Engineered Context-Sensitive Agonism : Tissue-Selective Drug Signaling through a G Protein-Coupled Receptor, file dfa8b997-21e9-748b-e053-3a05fe0a3a96
|
7
|
|
Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization, file dfa8b992-ada2-748b-e053-3a05fe0a3a96
|
6
|
|
Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes, file dfa8b995-7f08-748b-e053-3a05fe0a3a96
|
6
|
|
Investigating the hydrogen-bond acceptor site of the nicotinic pharmacophore model : a computational and experimental study using epibatidine-related molecular probes, file dfa8b994-2dde-748b-e053-3a05fe0a3a96
|
5
|
|
Allosteric modulation of alpha7 nicotinic receptors : mechanistic insight through metadynamics and essential dynamics, file dfa8b994-4a9d-748b-e053-3a05fe0a3a96
|
5
|
|
Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation, file dfa8b9a3-a13d-748b-e053-3a05fe0a3a96
|
5
|
|
Ligand-Specific Allosteric Coupling Controls G-Protein-Coupled Receptor Signaling, file dfa8b9a3-c42a-748b-e053-3a05fe0a3a96
|
5
|
|
M2 Muscarinic Receptor Stimulation Induces Autophagy in Human Glioblastoma Cancer Stem Cells via mTOR Complex-1 Inhibition, file ac2c8df0-72e9-480b-8ef1-3e17ff684dc1
|
4
|
|
Gaucher Disease: A Glance from a Medicinal Chemistry Perspective, file bcb8a466-1f8f-4198-82c5-cec67efbdc2b
|
4
|
|
On the selection of an opioid for local skin analgesia: Structure-skin permeability relationships, file dfa8b992-5ea1-748b-e053-3a05fe0a3a96
|
4
|
|
Synthesis and binding affinity at α4β2 and α7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system, file dfa8b994-1e3b-748b-e053-3a05fe0a3a96
|
4
|
|
A new molecular mechanism to engineer protean agonism at a G protein-coupled receptor, file dfa8b998-2c9b-748b-e053-3a05fe0a3a96
|
4
|
|
A Small Library of 1,2,3-Triazole Analogs of CAP-55: Synthesis and Binding Affinity at Nicotinic Acetylcholine Receptors, file dfa8b99b-e88a-748b-e053-3a05fe0a3a96
|
4
|
|
Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation, file dfa8b99c-18ca-748b-e053-3a05fe0a3a96
|
4
|
|
G protein inhibitors unravel Gq-dependent adenylyl cyclase activation in CHO-M1 cells, file dfa8b9a3-c693-748b-e053-3a05fe0a3a96
|
4
|
|
Photoswitchable ligands for light-mediated control of α7 nicotinic acetylcholine receptors: design, synthesis and photochromic characterization, file dfa8b9a7-9972-748b-e053-3a05fe0a3a96
|
4
|
|
Novel Analgesic Agents Obtained by Molecular Hybridization of Orthosteric and Allosteric Ligands, file f5b97f9a-fc88-4186-b3ca-8e27ef4f522b
|
4
|
|
M2 Muscarinic Receptor Stimulation Induces Autophagy in Human Glioblastoma Cancer Stem Cells via mTOR Complex-1 Inhibition, file 03f5dd46-d906-4c06-88d2-5216d501e70c
|
3
|
|
Sigma receptor and aquaporin modulators: chiral resolution, configurational assignment, and preliminary biological profile of RC752 enantiomers, file 407fb8e9-3a7e-42e1-9a0f-b1d1fae7ee35
|
3
|
|
Gaucher Disease: A Glance from a Medicinal Chemistry Perspective, file 8083ae8a-078b-4a3e-b483-1b3e05e55160
|
3
|
|
ICH3, a selective alpha7 nicotinic acetylcholine receptor agonist, modulates adipocyte inflammation associated with obesity, file 8ba3d165-2b83-4cdf-993c-530ce517238b
|
3
|
|
Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: Synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity, file dfa8b994-15ae-748b-e053-3a05fe0a3a96
|
3
|
|
Dualsteric compounds modulate the signaling pattern of muscarinic M1 acetylcholine receptors, file dfa8b994-f0bf-748b-e053-3a05fe0a3a96
|
3
|
|
Synthesis of a group of novel Xanomeline/77-LH-28-1 hybrid ligands and their FRET investigation at muscarinic acetylcholine receptor subtypes, file dfa8b999-f201-748b-e053-3a05fe0a3a96
|
3
|
|
Activation of M2 muscarinic acetylcholine receptors by a hybrid agonist enhances cytotoxic effects in GB7 glioblastoma cancer stem cells, file dfa8b99b-e82b-748b-e053-3a05fe0a3a96
|
3
|
|
Dualsteric compounds to induce signaling pathway selectivity in CHO-M1 cells, file dfa8b9a3-d197-748b-e053-3a05fe0a3a96
|
3
|
|
Synthesis and characterization of 13C labeled carnosine derivatives for isotope dilution mass spectrometry measurements in biological matrices, file dfa8b9a7-e5ae-748b-e053-3a05fe0a3a96
|
3
|
|
Use of acridinium-based photocatalyst in the Giese-type coupling of arylboronic acids with electron poor olefins, file f3075607-2bc0-4ac2-81cd-f26fb0fe5c2d
|
3
|
|
Novel ligands for neuronal nicotinic receptor subtypes: synthetic, pharmacological and molecular docking studies, file dfa8b992-4e71-748b-e053-3a05fe0a3a96
|
2
|
|
Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors, file dfa8b993-e63a-748b-e053-3a05fe0a3a96
|
2
|
|
Design of novel α7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies, file dfa8b995-5080-748b-e053-3a05fe0a3a96
|
2
|
|
Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters, file dfa8b995-7f06-748b-e053-3a05fe0a3a96
|
2
|
|
Dynamic ligand binding of dualsteric (allosteric/orthosteric) molecular probes controls the graded activation of muscarinic acetylcholine receptors, file dfa8b996-d542-748b-e053-3a05fe0a3a96
|
2
|
|
A novel spirocyclic tropanyl-Delta(2)-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake, file dfa8b998-4544-748b-e053-3a05fe0a3a96
|
2
|
|
Tacrine/Xanomeline hybrid ligands: synthesis and pharmacological evaluation at M1 muscarinic acetylcholine receptors and acetylcholinesterases, file dfa8b99c-7990-748b-e053-3a05fe0a3a96
|
2
|
|
Novel Hybrid Inhibitors of Cholinesterases as Potential Anti-Alzheimer Agents, file dfa8b9a3-b0b6-748b-e053-3a05fe0a3a96
|
2
|
|
Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake, file dfa8b9a8-a97a-748b-e053-3a05fe0a3a96
|
2
|
|
Photoswitchable ligands for light-mediated control of α7 nicotinic acetylcholine receptors: design, synthesis and photochromic characterization, file dfa8b9a8-aebb-748b-e053-3a05fe0a3a96
|
2
|
|
Synthesis, Binding Affinity at Glutamic Acid Receptors, Neuroprotective Effects, and Molecular Modeling Investigation of Novel Dihydroisoxazole Amino Acids, file dfa8b9a8-d97a-748b-e053-3a05fe0a3a96
|
2
|
|
Synthesis of 3-hydroxy- and 3-carboxy-Delta(2)-isoxazoline amino acids and evaluation of their interaction with GABA receptors and transporters, file dfa8b9a8-d97e-748b-e053-3a05fe0a3a96
|
2
|
|
Involvement of α7 nAChR subtype in rat oxaliplatin-induced neuropathy: Effects of selective activation, file 1cecd9cc-315c-45dc-8398-65e11f084a16
|
1
|
|
Involvement of α7 nAChR subtype in rat oxaliplatin-induced neuropathy: Effects of selective activation, file 3e8cfcfb-dc34-4435-98e0-75d28e1de1dc
|
1
|
|
Design of Cyclopentaisoxazoline Amino Acids as Conformationally Constrained Agonists at Glutamate Receptors, file 5a4f0c77-bb88-41d2-9f34-77abc1440277
|
1
|
|
Use of acridinium-based photocatalyst in the Giese-type coupling of arylboronic acids with electron poor olefins, file 7f146f13-ad41-4562-b292-0c8dd172a66c
|
1
|
|
Identification of novel potential B4GALT6 inhibitors through a large scale virtual screening, file 9a1b5f39-8237-4056-8557-ffcd98157c5d
|
1
|
|
(Trans)dermal delivery of opioids: a structure-permeability relationship, file dfa8b992-8742-748b-e053-3a05fe0a3a96
|
1
|
|
Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor, file dfa8b993-e7cc-748b-e053-3a05fe0a3a96
|
1
|
|
Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor, file dfa8b994-2626-748b-e053-3a05fe0a3a96
|
1
|
|
Synthesis and pharmacological characterization at glutamate receptors of erythro- and threo-tricholomic acid and homologues thereof, file dfa8b996-3558-748b-e053-3a05fe0a3a96
|
1
|
|
Insight into the Mechanism of Hydrolysis of Meropenem by OXA-23 Serine-β-lactamase Gained by Quantum Mechanics/Molecular Mechanics Calculations, file dfa8b996-737a-748b-e053-3a05fe0a3a96
|
1
|
|
Activation of M2 muscarinic acetylcholine receptors by orthosteric and dualsteric agonists in glioblastoma cancer stem cells: effects on cell proliferation and drug resistance, file dfa8b99c-160f-748b-e053-3a05fe0a3a96
|
1
|
|
Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid, file dfa8b9a8-b469-748b-e053-3a05fe0a3a96
|
1
|
|
A convenient synthesis of 4-(2-hydroxyethyl)indolin-2-one, a useful intermediate for the preparation of both dopamine receptor agonists and protein kinase inhibitors, file eaf80b13-c747-4e76-947a-d8b8d2713129
|
1
|
| Totale |
7.551 |