Plant polyphenolic compounds are considered a promising source for new antibacterial agents. In this study, we evaluated the antimicrobial activity of a collection of resveratrol-derived monomers and dimers screened as single molecules against a panel of nine foodborne pathogens. The results demonstrated that two monomers (i.e., pterostilbene 2 and (E)-3-hydroxy-4′,5-dimethoxystilbene 9) and three dimers (i.e., δ-viniferin 10, viniferifuran 14 and dehydro-δ-viniferin 15) were endowed with significant antibacterial activity against gram-positive bacteria. The exposure of gram-positive foodborne pathogens to 100 µg/mL of 2, 9 and 15 induced severe cell membrane damage, resulting in the disruption of the phospholipid bilayer. The most promising dimeric compound, dehydro-δ-viniferin 15, was tested against Listeria monocytogenes, resulting in a loss of cultivability, viability and cell membrane potential. TEM analysis revealed grave morphological modifications on the cell membrane and leakage of intracellular content, confirming that the cell membrane was the principal biological target of the tested derivative.
Antimicrobial activity of resveratrol-derived monomers and dimers against foodborne pathogens / L.M. Mattio, S. Dallavalle, L. Musso, R. Filardi, L. Franzetti, L. Pellegrino, P. D'Incecco, D. Mora, A. Pinto, S. Arioli. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 9:1(2019 Dec).
Titolo: | Antimicrobial activity of resveratrol-derived monomers and dimers against foodborne pathogens | |
Autori: | MATTIO, LUCE MICHELA (Primo) DALLAVALLE, SABRINA MARIA DONATELLA (Secondo) PINTO, ANDREA (Penultimo) ARIOLI, STEFANIA (Ultimo) | |
Settore Scientifico Disciplinare: | Settore CHIM/10 - Chimica degli Alimenti Settore AGR/16 - Microbiologia Agraria | |
Progetto: | PIANO DI SOSTEGNO ALLA RICERCA 2015-2017 - LINEA 2 "DOTAZIONE ANNUALE PER ATTIVITA' ISTITUZIONALE" PIANO DI SOSTEGNO ALLA RICERCA 2015-2017 - TRANSITION GRANT LINEA 1A PROGETTO "UNIMI PARTENARIATI H2020" | |
Data di pubblicazione: | dic-2019 | |
Rivista: | ||
Tipologia: | Article (author) | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/s41598-019-55975-1 | |
Appare nelle tipologie: | 01 - Articolo su periodico |
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