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Prodotti della ricerca: [326874] Home page macrotipologia

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Prodotti recenti

USING ARTIFICIAL INTELLIGENCE FOR DETECTING DISCRIMINATORY LANGUAGE

The rapid expansion of generative AI and large language models (LLM) has transformed how individuals and institutions communicate online. While these systems offer powerful capabilities for understanding natural language and generating natural language text, their ability to reliably detect linguistic patterns depends critically on the quality, completeness, and representativeness of their training data. As LLM become increasingly central to content moderation and language classification task...

TIMELESS QUESTIONS AND MODERN CHALLENGES: A JOURNEY FROM THE ORIGIN OF LIFE IN HYDROTHERMAL VENTS TO ELECTROCHEMICAL CO2 REDUCTION

The objective of the work presented here is to investigate the functioning of the alkaline hydrothermal vent from an electrochemical point of view in order to inspire new technologies for CO2 reduction. Oceanic hydrothermal vents (HTVs) are geological structures that played a key role 4 billion years ago in the formation of the very first organic molecules on our planet and, eventually, life itself. The minerals composing the vent structure, mainly iron (-nickel) sulphides and oxyhydroxide, s...

INSIGHTS ON THE CROSSTALK BETWEEN THE IMMUNE SYSTEMAND CANCER: IMMUNE CHECKPOINT MOLECULES AND LYMPHOIDPOPULATIONS ASSESSMENT IN CANINE ROUND CELL TUMORS

The crosstalk between the immune system and cancer represents a fundamental aspect of oncology, since a better understanding of disease mechanisms could lead to the development of novel therapeutic strategies. This PhD project focused on three main topics: (1) the expression and prognostic role of programmed death-ligand 1 (PD-L1) in canine lymphoma, (2) the expression and prognostic role of CD47 in canine leukemias, and (3) the characterization of lymphocyte populations in peripheral bloo...

THE INTERGENERATIONAL IMPACT OF ENVIRONMENTAL EXPOSURES: MOLECULAR INSIGHTS FROM MODELLING PLURIPOTENCY TRANSITIONS THROUGH THE HUMAN GERMLINE

How environmental exposures shape inheritance across generations is a fundamental question in biology, with far-reaching implications for human health. Despite evidence of such inheritance in animal models, its mechanisms and relevance in humans remain elusive due to key challenges: (i) the inaccessibility of developing germ cells from exposed individuals; (ii) the predominance in the field of methodological approaches based on the investigation of single molecular layers; (iii) the impossibi...

UNCOVERING LNCRNA-CHROMATIN INTERACTIONS SHAPING HUMAN MONOCYTE TO MACROPHAGE DIFFERENTIATION

Mammalian genomes are pervasively transcribed, producing a large repertoire of coding and non-coding transcripts, that can associate with chromatin and contribute to the regulation of genome organization and gene expression. However, the functional roles of most chromatin-associated RNAs, particularly long non-coding RNAs (lncRNAs), are still being elucidated, with new functions continuously emerging as the filed advances. In recent years, several technologies have been developed to study R...

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