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Prodotti della ricerca: [329730] Home page macrotipologia

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Prodotti recenti

Botulinum neurotoxin serotype D is poorly effective in humans: An in vivo electrophysiological study

Objective: Botulinum neurotoxins act on nerve endings and block neurotransmitter release. Their potency is due to their enzymatic activity and high affinity binding to neurons. Botulinum toxin type A is used in the treatment of human diseases characterized by hyperactivity of peripheral cholinergic nerve terminals, but some patients are or become resistant to it. This can be overcome by using other botulinum toxins, and studies have been performed with different toxin serotypes. Botulinum neu...

The frequent exacerbator phenotype in bronchiectasis revisited: data from EMBARC registry

Rationale: The frequent exacerbator phenotype was previously defined using a threshold of ≥3 exacerbations per year in bronchiectasis. However, the contribution of each prior exacerbation to future risk as well as the influence of severe exacerbations and different etiologies and regions remain poorly understood. Objectives: To quantify the risk associated with each prior exacerbation of bronchiectasis in predicting future exacerbations and severe exacerbations, and to determine whether this...

Abobotulinumtoxina: A new therapy for hip osteoarthritis. A prospective randomized double-blind multicenter study

Background: Hip Osteoarthritis (OA) causes pain and disability. Here we evaluate abobotulinumtoxinA (Dysport®) (AboBoNT-A) injections versus placebo as a novel treatment option to improve hip range of motion, pain and quality of life. Methods: This prospective randomized double-blind multicenter study (EudraCT # 2012-004890-25) recruited 46 outpatients with hip OA who were randomized 2:1 to the Treatment Group (TG; 31 subjects), or the Placebo Group (PG; 15 subjects). The TG received 400 U of...

Skin Biopsy May Help to Distinguish Multiple System Atrophy–Parkinsonism from Parkinson's Disease With Orthostatic Hypotension

Background: The differential diagnosis between multiple system atrophy parkinsonism type (MSA-P) and Parkinson's disease with orthostatic hypotension (PD+OH) is difficult because the 2 diseases have a similar clinical picture. The aim of this study is to distinguish MSA-P from PD+OH by immunostaining for abnormal phosphorylated α-synuclein at serine 129 (p-syn) in cutaneous nerves. Method: We recruited 50 patients with parkinsonism and chronic orthostatic hypotension: 25 patients fulfilled th...

Neurodevelopmental timing of social learning in mice

Observational learning constitutes a key feature in mammals’ evolution, including mice. Unlike trial-and-error strategies, it constitutes a more efficient learning approach. Indeed, by witnessing a demonstrator’s behavior, an observer can detect the action-outcome relationship avoiding risks of wrong choices. Despite previous studies reported this ability in mice, it remains unclear how it emerges and evolves across neurodevelopment. In this study, we investigate how observational learnin...

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