IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

Systematic literature review and trial-level meta-analysis of aromatase inhibitors vs tamoxifen in patients with HR+/HER2- early breast cancer

Background: Current standard of care for patients with HR+/HER2− early breast cancer (EBC) includes adjuvant endocrine therapy with an aromatase inhibitor (AI) or tamoxifen (TAM). We present a trial-level meta-analysis on efficacy of AI vs TAM in patients with HR+/HER2− EBC. Methods: A systematic literature review was conducted using key medical literature databases (eg, PubMed; inception to October 2023) and data from conferences (to December 2023). Phase 3 randomized controlled trials (RCTs...

I sistemi ad altro rischio in materia di immigrazione : Commento all’Allegato III, par. 7

Clinician's guide: expert insights on the use of CDK4/6 inhibitors in patients with early breast cancer

The introduction of the cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors abemaciclib and ribociclib to the adjuvant setting marks a significant advancement in the treatment of hormone-receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer (HR+, HER2− EBC). Despite significant strides in early detection and treatment, many patients continue to face the risk of disease recurrence, highlighting the need for more effective adjuvant therapies. These CDK4/6 inh...

“Cum prius de lignamine castrum fecissent, modo fecerunt de muro” : The Destruction of Rural Fortresses and Its Political Significance in Northern Italy During the Age of Communes (Twelfth–Thirteenth Centuries)

This essay explores the conflicts triggered by the presence of stone fortifications in communal northern Italy between the twelfth and thirteenth centuries. It focuses on three primary areas of tension involving the communes: confrontations with territorial powers, inter-city conflicts, and struggles against political exiles. Drawing on a selection of case studies, the analysis highlights the diverse motivations behind the destruction of stone fortresses, examining their military, political, ...