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Prodotti della ricerca: [318415] Home page macrotipologia

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Prodotti recenti

An Innovative Tool for Measuring Sunlight Propagation Through Different Snowpacks

Sunlight penetration in the snowpack plays a fundamental role in many environmental processes, ranging from local energy balance to snow microbiology and can potentially contribute to climate change. In addition, many photochemical reactions typically occur in the snowpack driven by solar radiation. Although a few measurements have been attempted in the past decades, light penetration through the snowpack is currently almost only modeled numerically, frequently using severe assumptions. The l...

PATHOGENETIC DEFINITION OF THE MECHANISMS UNDERLYING THE NOVEL FAMILY OF PLIN4 GENE EXPANSION-RELATED MYOPATHY

La miopatia causata da mutazione nel gene PLIN4 è una rara patologia caratterizzata da esordio tardivo e progressiva debolezza muscolare. Fino ad oggi, sono state identificate due mutazioni causative: un’espansione di blocchi di 99 nucleotidi e una duplicazione di 14 blocchi, identificata recentemente e caratterizzata durante il mio percorso di dottorato. Entrambi i riarrangiamenti interessano l’esone 5 del gene PLIN4 che codifica per l’elica amfipatica della proteina. Perilipina 4 appartiene...

ESTABLISHING AN IN VITRO MODEL FOR CRISPR-CAS9 SCREENING OF INTERFERON EFFECTORS IN HBV INFECTION

Hepatitis B virus (HBV) is a hepatotropic virus that can cause both acute and chronic liver infection. According to the World Health Organization, 254 million people were living with chronic hepatitis B virus (CHB) infection in 2022, with approximately 1.2 million new cases each year. While vaccination prevents new infections, CHB still leads to cirrhosis and hepatocellular carcinoma, contributing to over one million deaths annually and underscoring the need for improved therapies (World Heal...

THE ROLE OF CD4+ T MEMORY SUBSETS IN HIV INFECTION: IMMUNE RESPONSE IN PEOPLE WITH HIV AND LATENCY ESTABLISHMENT

T lymphocytes comprise diverse subsets which differ in phenotype, function and maturation level. Among them, T memory stem cells (TSCM) represent the more developmentally immature subpopulation of the memory pool, endowed with longevity, self-renewing capacity and multipotency, other than recall capabilities. These features make them pivotal for maintaining durable immune memory and controlling persistent infections. In the context of vaccination, the induction of vaccine-specific TSCM is a...

KUPFFER CELLS¿ MITOCHONDRIAL PLASTICITY AFFECTS SYSTEMIC IMMUNO-METABOLISM

BACKGROUND: Kupffer cells (KCs) are hepatic resident macrophages that are essential for liver physiology and contribute to the development of metabolic-associated fatty liver disease (MAFLD). Due to their high plasticity, KCs can maintain immunotolerance and mediate cell-cell interaction within the hepatic niche, playing both an immune and metabolic role. As a result, KCs require large amounts of energy to perform their functions, which is why mitochondria turn out to be critical for their fu...

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