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Prodotti della ricerca: [326255] Home page macrotipologia

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Prodotti recenti

Circulating tumor DNA: a biomarker for oncology drug development in phase I clinical trials?

Introduction: Circulating tumor DNA (ctDNA) is a noninvasive and promising biomarker for cancer diagnosis, prognosis, and therapeutic monitoring, offering significant potential for real-time insights into tumor dynamics when compared to traditional tissue-based biopsies. Phase I oncology clinical trials, which primarily focus on assessing the safety, pharmacodynamics, and early activity of novel cancer therapies, might find in the unique biological characteristics of ctDNA, a valuable biomark...

Measurement of ψ(2S) to J/ψ cross-section ratio as function of multiplicity in pPb collisions at $$ \sqrt{s_{\textrm{NN}}}=8.16 $$ TeV

The production ratio of ψ(2S) to J/ψ charmonium states is presented as a function of multiplicity in proton-lead collisions at a centre-of-mass energy of sNN=8.16 TeV, for both prompt and nonprompt sources. The total luminosity recorded by the LHCb experiment corresponds to 13.6 nb−1 for pPb collisions and 20.8 nb−1 for Pbp collisions, where the first particle corresponds to the particle traveling towards the detector. Measurements are performed in the dimuon final state at forward (backward)...

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental ab...

Glioblastoma: Overview of Proteomic Investigations and Biobank Approaches for the Development of a Multidisciplinary Translational Network

Glioblastoma is a highly aggressive, infiltrative brain tumor of the central nervous system (CNS). Its extensive molecular and biochemical heterogenicity hinders the identification of reliable biomarkers and therapeutic targets, thereby making prognosis and existing therapy ineffective. In recent years, breakthroughs in the use of proteomics on a range of biological samples, such as plasma, cerebrospinal fluid (CSF), tissues, brain cells, and exosomes, represent a potential improvement to GBM...

A time bridge for obesity care: protein monitoring adds a timing layer to the EASO pathway while preserving the Lancet Commission definition

The European Association for the Study of Obesity (EASO) frames obesity care around staged, target-driven decisions. The Lancet Diabetes & Endocrinology Commission provides a disease definition-clinical obesity requires objective dysfunction- and distinguishes preventive strategies for preclinical obesity from therapeutic strategies for clinical obesity. Continuous protein monitoring (CPM) refers to wearable or minimally invasive sensors that repeatedly measure short panels of proteins in...

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