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Prodotti della ricerca: [325063] Home page macrotipologia

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Prodotti recenti

LIGAND- AND STRUCTURE-BASED METHODS FOR IN SILICO TARGET IDENTIFICATION

Understanding the interactions between small molecules and their protein targets is a central challenge in drug discovery, underpinning the development of new therapeutics and the rational design of chemical probes. Despite the availability of large-scale bioactivity data, significant variability in experimental conditions, reporting formats, and structural representations often limits their utility for computational modeling and machine learning applications. To address these challenges, cur...

EMPHASIZING THE OPPONENTS' ISSUES. A COMPARATIVE ANALYSIS ON THE INCENTIVES AND OUTCOMES OF POLITICAL PARTIES IN EUROPE

The aim of the thesis is to advance a deeper understanding of the incentives and electoral outcomes of a specific party strategy: the emphasis of issues that not only fall outside the party’s ideological domain but that lie within the opponents’ one. The existing approaches on the matter have focused on the convergence of parties on the same issues while the specific choice to emphasize issues ideologically distinctive of the opponents remained underexplored, a gap this thesis addresses. Al...

THE LOCATION OF DAMAGE IN THE EU CONFLICT OF LAWS: THE CASE OF FINANCIAL LOSS IN THE CONTEXT OF BLOCKCHAIN TRANSACTIONS

Starting from a technical reconstruction of the blockchain, understood as a distributed ledger, and an analysis of the regulatory initiatives proposed at international, European and national level to regulate its use, the thesis analyses the case of pure financial loss that may occur when financial investments are made using these new technologies and the resulting impact from an international private law perspective. Part I introduces blockchain technology and the private international lega...

Evoluzione terapeutica: tradurre l'innovazione farmacologica in benefici tangibili per le persone con emofilia A. Una prospettiva multi-stakeholder

The advances that have marked the history of hemophilia represent a concrete example of therapeutic evolution. The progress made over the years has been able to revolutionize its treatment, bringing about a radical change both in the therapeutic algorithm and in life expectancy. Considering the recent milestones achieved, it would be anachronistic to maintain the same therapeutic goals as in the past; the normalization of hemostasis is the path leading to the ultimate therapeutic goal, which ...

Chirality Effect on Physical and Biological Properties of Peptide-Based Hydrogels

The self-assembly of peptide-based building blocks into ordered structures is widely exploited for the development of novel biomaterials, including hydrogels. In this review, we analyze the effect of chirality on the ability of peptides to form hydrogels. We describe systems composed of peptides of opposite chirality i.e., peptides composed of all L- or D-amino acids and peptides composed of amino acids with alternate chirality, i.e., one L- and D-amino acid or one block containing all L...

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