IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

Letter: Optimizing Dupilumab Dosing in Atopic Dermatitis: Real-World Evidence

Degrees of H2AX phosphorylation correlate with unique features of the intratumoral immune microenvironment in colorectal carcinomas

Background: The phosphorylated form of the histone H2AX (γH2AX), a sensor of DNA double-strand breaks (DSB), can serve as a biomarker of DNA damage and therapy response. This study aimed to evaluate the association between γH2AX expression and pathological, molecular, and immune features in colorectal cancer (CRC). Patients and methods: Levels of γH2AX were assessed by immunohistochemistry in a cohort of 198 CRCs, alongside immune-related markers (CD3 and CD8). A sub-cohort of 65 CRCs (26 γH2...

Improving the Reconstruction of the Hydrological Cycle through Satellite Observations: The Case Study of the Po River Basin

Climate change is having a detrimental impact on the availability of water resources, and the effects are found to be particularly pronounced in regions where human activity is more concentrated. Across the world, the rising frequency of meteorological, agricultural, and hydrological droughts highlight the urgency of understanding how human activities contribute to their occurrence, which is crucial for effective water management. Specifically, estimating water storage in groundwater, reservo...

Dietary choline content and hdl levels modulate gut microbiota composition and contribute to a pro-atherogenic plasma metabolomic profile in mice

Background and Aims: Gut microbiota can influence atherosclerosis development by metabolizing dietary choline: experimental and observational studies have highlighted a positive correlation between increased plasma choline-derived TMAO concentrations and adverse cardiovascular events. This study was aimed at investigating how the plasma metabolome of mice prone to atherosclerosis development was modulated by HDL levels and the dietary intake of choline. Methods: Low-fat, no cholesterol die...