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Prodotti della ricerca: [328915] Home page macrotipologia

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Prodotti recenti

Association between body mass index and major cancers with a focus on breast in South and Southeast Asia: A regional systematic review and meta-analysis

Objectives: We investigated the association between body mass index (BMI) and cancer at different sites among adults in South and Southeast Asia in a systematic review. Material and Methods: We conducted an electronic database search on PubMed, Embase, CINAHL, and Web of Science, in accordance with the PROSPERO protocol (registration No. CRD42023427644). Studies that reported the association of BMI and cancer incidence in South and Southeast Asian countries were included. We assessed t...

TMS–EEG Reveals Causal Dynamics of the Premotor Cortex during Musical Improvisation

Musical improvisation illustrates the brain's capacity for flexible, creative motor control, yet the causal mechanisms underlying this complex behavior remain poorly understood. We employed transcranial magnetic stimulation combined with electroencephalography (TMS–EEG) to probe state-dependent cortical dynamics in the left dorsal premotor cortex (PMd) of professional jazz pianists (n = 3) during improvisation, sight-reading, and rest. This proof-of-concept study demonstrates the feasibility ...

Restoration of visual acuity and visually guided behavior in ambient white light with photoswitchable small molecules

Blinding diseases caused by photoreceptor (PhR) degeneration, such as geographic atrophy (GA) secondary to dry age-related macular degeneration and retinitis pigmentosa (RP), leave most inner retinal circuitry structurally intact but unable to respond to light. Current therapeutic options remain limited. Gene therapy benefit only small, mutation-defined subsets of RP patients, while electronic retinal prostheses are invasive, costly, and provide limited visual resolution. Photopharmacology ca...

Targeting Pseudomonas aeruginosa LecB with Photoswitchable Glycomimetic Ligands

Antimicrobial resistance (AMR) represents an escalating global health challenge, particularly in relation to nosocomial infections. A key factor driving the persistence and dissemination of AMR is the formation of biofilms, which establish a protective microenvironment that promotes microbial survival and facilitates horizontal gene transfer (1). Bacterial adhesion proteins play a fundamental role in biofilm initiation and maturation by mediating interactions between microbial cells and bioti...

Next generation sequencing (NGS): A revolutionary technology in pharmacogenomics and personalized medicine in cancer

Following the completion of the Human Genome Project in 2003, research in oncology has progressively focused on the sequencing of cancer genomes, with the aim of better understanding the genetic basis of oncogenesis and identifying actionable alterations. The development of next-generation-sequencing (NGS) techniques, commercially available since 2006, allowed for a cost- and time-effective sequencing of tumor DNA, leading to a “genomic era” of cancer research and treatment. NGS provided a si...

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