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Prodotti della ricerca: [318490] Home page macrotipologia

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Prodotti recenti

Neurology and physician-assisted suicide: position of the Italian society of neurology

This position paper explores the complex issue of Physician-Assisted Suicide (PAS) in the context of Neurology. It discusses the legal, ethical, and clinical challenges surrounding PAS, including the role of neurologists in assessing eligibility based on prognosis, decision-making capacity, and functional status. The paper outlines Italy’s legal framework regarding PAS, following a landmark 2019 Constitutional Court ruling, which permits PAS under strict conditions for patients suffering from...

Frontotemporal dementia characterization using neurite orientation dispersion and density imaging

Microstructural alterations in brain tissue play a crucial role in the pathophysiology of frontotemporal dementia (FTD). This study assessed brain white matter (WM) and grey-matter (GM) microstructure in FTD variants using neurite orientation dispersion and density imaging (NODDI) diffusion MRI model and developed an exploratory machine-learning algorithm to classify FTD subtypes according to diffusion MRI metrics. Brain MRI including multi-shell diffusion sequences and neuropsychological ass...

Rate of change in upper and lower motor neuron burden is associated with survival in amyotrophic lateral sclerosis

Background: We hypothesize that the rate of change in upper (ΔUMN) and lower (ΔLMN) motor neuron signs from symptom onset to first clinical assessment represent best predictors of survival and disease progression in amyotrophic lateral sclerosis (ALS) compared to singular quantification of UMN and LMN involvement. Methods: A retrospective inpatient cohort of 1000 ALS patients was evaluated. The burden of UMN and LMN signs was assessed using the Penn Upper Motor Neuron Score and Lower Motor Ne...

Cortical Excitability as a Prognostic and Phenotypic Stratification Biomarker in Amyotrophic Lateral Sclerosis

Objective: Despite its clinical heterogeneity, amyotrophic lateral sclerosis is unified by early and prominent alterations in cortical excitability, increasingly recognized as contributors to disease progression. This study assessed whether the ratio between motor evoked potential (MEP) amplitude, reflecting upper motor neuron integrity, and compound muscle action potential (CMAP) amplitude, indexing lower motor neuron function, could provide an accessible marker of corticospinal excitability...

Distinctive Progression Patterns of Brain Structural Damage Aid Classification of Frontotemporal Dementia Variants

Background: Frontotemporal dementia (FTD) encompasses diverse clinical phenotypes, primarily characterized by behavioral and/or language dysfunction. A newly characterized variant, semantic behavioral variant FTD (sbvFTD), exhibits predominant right temporal atrophy with features bridging behavioral variant FTD (bvFTD) and semantic variant primary progressive aphasia (svPPA). This study investigates the longitudinal structural MRI correlates of these FTD variants, focusing on cortical and sub...

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