BESUSSO, DARIO
BESUSSO, DARIO
Dipartimento di Bioscienze
A human CAGinSTEM platform for decoding HTT repeats’ somatic instability links CAG interruption to HD pathology in neurons
2025 M. Zobel, G. Damaggio, M.L. Mignogna, D. Besusso, D. Scalzo, A. Cossu, C. Trovesi, M. Crosti, F. Cortina, I. Campus, G. Formenti, S. Mazzara, F. Gregoretti, L. Antonelli, G. Oliva, C. Zuccato, V. Colonna, P. Conforti, M. Cereda, R. Lorenzo Rossi, S. Maestri, A. Scolz, R. Iennaco, E. Cattaneo
When repetita no-longer iuvant: somatic instability of the CAG triplet in Huntington’s disease
2025 E. Cattaneo, D. Scalzo, M. Zobel, R. Iennaco, C. Maffezzini, D. Besusso, S. Maestri
Transplanted human striatal progenitors exhibit functional integration and modulate host circuitry in a Huntington’s disease animal model
2025 L. Scaramuzza, M. Ribodino, C. Cassarino, M. Morrocchi, G.B. Gomez Gonzalez, R. Parolisi, E. Sozzi, G. Turrini, V. Cerrato, P. Conforti, E. Hoxha, R. Tognato, G. Galeotti, C. Cordiglieri, M.C. Crosti, S. Zucca, M. Lorenzati, S. Bovetti, P. Spaiardi, C. De'Sperati, G. Biella, L. Ottoboni, M. Parmar, S. Maestri, D. Besusso, E. Cattaneo, A. Buffo
Stem Cell Revolutions: An alliance for Parkinson’s disease driven by European Commission consortia
2025 E. Cattaneo, D. Besusso
Navigating triplet repeats sequencing: concepts, methodological challenges and perspective for Huntington’s disease
2025 S. Maestri, D. Scalzo, G. Damaggio, M. Zobel, D. Besusso, E. Cattaneo
Huntington’s disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids
2024 M. Galimberti, M.R. Nucera, V.D. Bocchi, P. Conforti, E. Vezzoli, M. Cereda, C. Maffezzini, R. Iennaco, A. Scolz, A. Falqui, C. Cordiglieri, M. Cremona, I. Espuny-Camacho, A. Faedo, D.P. Felsenfeld, T.F. Vogt, V. Ranzani, C. Zuccato, D. Besusso, E. Cattaneo
Neuroprotection by ADAM10 inhibition requires TrkB signaling in the Huntington’s disease hippocampus
2024 A. Scolz, E. Vezzoli, M. Villa, F. Talpo, J. Cazzola, F. Raffin, C. Cordiglieri, A. Falqui, G. Pepe, V. Maglione, D. Besusso, G. Biella, C. Zuccato
hESC-derived striatal progenitors grafted into a Huntington’s disease rat model support long-term functional motor recovery by differentiating, self-organizing and connecting into the lesioned striatum
2023 R. Schellino, D. Besusso, R. Parolisi, G.B. Gómez-González, S. Dallere, L. Scaramuzza, M. Ribodino, I. Campus, P. Conforti, M. Parmar, M. Boido, E. Cattaneo, A. Buffo
Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes
2022 Y. Wang, S. Chiola, G. Yang, C. Russell, C.J. Armstrong, Y. Wu, J. Spampanato, P. Tarboton, H.M.A. Ullah, N.U. Edgar, A.N. Chang, D.A. Harmin, V.D. Bocchi, E. Vezzoli, D. Besusso, J. Cui, E. Cattaneo, J. Kubanek, A. Shcheglovitov
In vitro-derived medium spiny neurons recapitulate human striatal development and complexity at single-cell resolution
2022 P. Conforti, V.D. Bocchi, I. Campus, L. Scaramuzza, M. Galimberti, T. Lischetti, F. Talpo, M. Pedrazzoli, A. Murgia, I. Ferrari, C. Cordiglieri, A. Fasciani, E. Arenas, D. Felsenfeld, G. Biella, D. Besusso, E. Cattaneo
The coding and long noncoding single-cell atlas of the developing human fetal striatum
2021 V.D. Bocchi, P. Conforti, E. Vezzoli, D. Besusso, C. Cappadona, T. Lischetti, M. Galimberti, V. Ranzani, R.J.P. Bonnal, M.D. De Simone, G. Rossetti, X. He, K. Kamimoto, I. Espuny-Camacho, A. Faedo, F. Gervasoni, R. Vuono, S.A. Morris, J. Chen, D. Felsenfeld, G. Pavesi, R.A. Barker, M. Pagani, E. Cattaneo
Modeling autism-associated SHANK3 deficiency using human cortico-striatal organoids generated from single neural rosettes
2021 Y. Wang, S. Chiola, G. Yang, C. Russell, C.J. Armstrong, Y. Wu, J. Spampanato, P. Tarboton, A.N. Chang, D.A. Harmin, E. Vezzoli, D. Besusso, J. Cui, E. Cattaneo, J. Kubanek, A. Shcheglovitov
hiPSCs for predictive modelling of neurodegenerative diseases : dreaming the possible
2021 P. Rivetti di Val Cervo, D. Besusso, P. Conforti, E. Cattaneo
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease
2021 F. Cozzolino, E. Vezzoli, C. Cheroni, D. Besusso, P. Conforti, M. Valenza, I. Iacobucci, V. Monaco, G. Birolini, M. Bombaci, A. Falqui, P. Saftig, R.L. Rossi, M. Monti, E. Cattaneo, C. Zuccato
Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease
2020 D. Besusso, R. Schellino, M. Boido, S. Belloli, R. Parolisi, P. Conforti, A. Faedo, M. Cernigoj, I. Campus, A. Laporta, V. Bocchi, V. Murtaj, M. Parmar, P. Spaiardi, F. Talpo, C. Maniezzi, M.G. Toselli, G. Biella, R.M. Moresco, A. Vercelli, A. Buffo, E. Cattaneo
RUES2 hESCs exhibit MGE-biased neuronal differentiation and muHTT-dependent defective specification hinting at SP1
2020 P. Conforti, D. Besusso, S. Brocchetti, I. Campus, C. Cappadona, M. Galimberti, A. Laporta, R. Iennaco, R.L. Rossi, V. Bocchi, E. Cattaneo
A CRISPR-strategy for the generation of a detectable fluorescent hESC reporter line (WAe009-A-37) for the subpallial determinant GSX2
2020 D. Besusso, A. Cossu, A. Mohamed, M. Cernigoj, P. Codega, M. Galimberti, I. Campus, P. Conforti, E. Cattaneo
PD-1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state
2019 I. Mair, D. Besusso, L. Saul, S.D. Patel, R. Ravindran, R.C. Mcpherson, M.D. Leech, R.A. O'Connor, S.M. Anderton, R.J. Mellanby
Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington’s disease
2019 E. Vezzoli, I. Caron, F. Talpo, D. Besusso, P. Conforti, E. Battaglia, E. Sogne, A. Falqui, L. Petricca, M. Verani, P. Martufi, A. Caricasole, A. Bresciani, O. Cecchetti, P.R. Di Val Cervo, G. Sancini, O. Riess, H. Nguyen, L. Seipold, P. Saftig, G. Biella, E. Cattaneo, C. Zuccato
Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes
2018 P. Conforti, D. Besusso, V.D. Bocchi, A. Faedo, E. Cesana, G. Rossetti, V. Ranzani, C.N. Svendsen, L.M. Thompson, M. Toselli, G. Biella, M. Pagani, E. Cattaneo