IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

LECCA, DAVIDE
 Distribuzione geografica
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Continente #
EU - Europa 7.229
NA - Nord America 5.002
AS - Asia 3.244
SA - Sud America 140
OC - Oceania 74
AF - Africa 29
Continente sconosciuto - Info sul continente non disponibili 5
Totale 15.723
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Nazione #
US - Stati Uniti d'America 4.881
GB - Regno Unito 1.935
CN - Cina 1.620
DE - Germania 1.616
IT - Italia 1.521
SE - Svezia 549
SG - Singapore 460
RU - Federazione Russa 372
IN - India 312
JP - Giappone 231
FR - Francia 224
IE - Irlanda 201
TR - Turchia 179
FI - Finlandia 138
HK - Hong Kong 133
KR - Corea 127
UA - Ucraina 121
DK - Danimarca 113
CA - Canada 95
BE - Belgio 87
ID - Indonesia 78
AU - Australia 69
NL - Olanda 68
ES - Italia 55
CH - Svizzera 53
BR - Brasile 51
EU - Europa 49
PL - Polonia 48
GR - Grecia 38
CO - Colombia 34
TW - Taiwan 26
MX - Messico 25
CL - Cile 22
AT - Austria 21
UY - Uruguay 18
CZ - Repubblica Ceca 13
IL - Israele 12
RO - Romania 12
PT - Portogallo 11
IR - Iran 9
SC - Seychelles 9
VN - Vietnam 9
RS - Serbia 8
AR - Argentina 7
SA - Arabia Saudita 7
TH - Thailandia 7
NG - Nigeria 6
PE - Perù 6
TN - Tunisia 6
HU - Ungheria 5
MY - Malesia 5
NO - Norvegia 5
NZ - Nuova Zelanda 5
PH - Filippine 4
PK - Pakistan 4
ZA - Sudafrica 4
A2 - ???statistics.table.value.countryCode.A2??? 3
AE - Emirati Arabi Uniti 3
BY - Bielorussia 3
HR - Croazia 3
IQ - Iraq 3
KW - Kuwait 3
AL - Albania 2
AM - Armenia 2
BD - Bangladesh 2
BT - Bhutan 2
EC - Ecuador 2
EG - Egitto 2
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BG - Bulgaria 1
BZ - Belize 1
EE - Estonia 1
IM - Isola di Man 1
KE - Kenya 1
LI - Liechtenstein 1
LK - Sri Lanka 1
MA - Marocco 1
MD - Moldavia 1
MK - Macedonia 1
MO - Macao, regione amministrativa speciale della Cina 1
OM - Oman 1
QA - Qatar 1
UZ - Uzbekistan 1
Totale 15.770
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Città #
Southend 1.596
Milan 711
Hanover 616
Chandler 420
Singapore 344
Frankfurt am Main 305
Beijing 277
Fairfield 265
Wilmington 254
Princeton 234
Ashburn 228
Seattle 225
Houston 199
Dublin 196
Ann Arbor 190
Woodbridge 181
Sunnyvale 162
Shanghai 143
Dearborn 142
Redwood City 138
Berlin 130
Mountain View 130
Nanjing 126
Cambridge 117
Hong Kong 89
Redmond 87
Grafing 82
Des Moines 77
Bengaluru 69
Boardman 68
Guangzhou 63
Istanbul 57
Phoenix 57
Shenyang 56
Santa Clara 55
Tokyo 55
Jacksonville 52
New York 50
Somerville 48
Jakarta 47
Helsinki 44
Brussels 41
Serra 41
Hangzhou 39
Medford 37
Jinan 36
Andover 34
London 33
Turin 32
Changsha 31
Rome 31
Chongqing 30
Paris 30
San Diego 30
Athens 29
Bogotá 29
Boston 29
Hefei 29
Hebei 28
Nanchang 28
Sakarya 28
Warsaw 28
Los Angeles 27
Toronto 27
Wuhan 27
Fuzhou 25
Zhengzhou 25
Bühl 24
Minamiota 22
Tianjin 22
Leipzig 21
Melbourne 21
Chengdu 20
Magenta 20
Jiaxing 19
Ottawa 19
Chicago 18
Denver 18
Falls Church 18
Ningbo 18
Silver Spring 18
Kunming 17
Taipei 17
Bonn 16
Brescia 16
Montevideo 16
Eitensheim 15
Odernheim 14
Rio de Janeiro 14
San Francisco 14
San Jose 14
Manchester 13
Nuremberg 13
Strasbourg 13
Taizhou 13
Buffalo 12
Madrid 12
Mannheim 12
Padova 12
Seoul 12
Totale 9.732
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Nome #
Pharmacological Properties and Biological Functions of the GPR17 Receptor, a Potential Target for Neuro-Regenerative Medicine 1.024
Regulation and signaling of the GPR17 receptor in oligodendroglial cells 546
SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation 527
The concise guide to pharmacology 2021/22 : G protein-coupled receptors 438
The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization 372
Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug 359
CNS remyelination as a novel reparative approach to neurodegenerative diseases : The roles of purinergic signaling and the P2Y-like receptor GPR17 354
In vivo silencing of miR-125a-3p promotes myelin repair in models of white matter demyelination 331
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair 286
Differential local tissue permissiveness influences the final fate of GPR17-expressing oligodendrocyte precursors in two distinct models of demyelination 268
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors 252
Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes 250
Prenatal Stress Impairs Spinal Cord Oligodendrocyte Maturation via BDNF Signaling in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis 241
The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor 224
Coinvolgimento di GPR17, un nuovo recettore duale per nucleotidi extracellulari e cistenil-leucotrieni, nell'ischemia cerebrale 207
Purple Corn Extract as Anti-allodynic Treatment for Trigeminal Pain : Role of Microglia 198
Dysregulation of GPR17, a key receptor involved in oligodendrocyte maturation, as a novel potential pathogenetic mechanism in demyelinating diseases 185
Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis 185
Novel in vitro experimental approaches to study myelination and remyelination in the central nervous system 183
Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor 178
MiR-125a-3p timely inhibits oligodendroglial maturation and is pathologically up-regulated in human multiple sclerosis 178
HEBE project: Healthy aging versus inflamm-aging: The role of physical exercise in modulating the biomarkers of age-associated and environmentally determined chronic diseases, study protocol 171
The P2Y-like GPR17 receptor orchestrates the transition between immature and myelinating oligodendrocytes and is a new target for myelin repair 168
A role for the P2Y-like GPR17 receptor in oligodendrocyte differentiation 163
Corn (ZEA MAYS L). extracts as source of active compounds with promising effects in reducing trigeminal pain through microbiota modulation 163
Pathway-Focused Profiling of Oligodendrocytes Over-Expressing miR-125a-3p Reveals Alteration of Wnt and Cell-to-Cell Signaling 163
MicroRNAs change the games in central nervous system pharmacology 161
A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitro 160
The Concise Guide to Pharmacology 2019/20: G protein-coupled receptors 160
Purinergic receptors on oligodendrocyte progenitors : promising targets for myelin repair in multiple sclerosis? 159
The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients 159
Different properties of P2X(7) receptor in hippocampal and cortical astrocytes 153
Expression pattern and distribution of the oligodendroglial receptor GPR17 in Experimental Autoimmune Encephalomyelitis, a mouse model of Multiple Sclerosis 150
The expression and intracellular trafficking of the P2Y-like receptor GPR17 in oligodendroglial cells 141
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview 141
The P2Y-like receptor GPR17 as a sensor of damage and a target of CNS repair 138
Stimulation of P2Y-like receptor GPR17 by both uracil nucleotides and cysteinyl-leukotrienes increases outward potassium currents in 1321N1 cells 137
Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells 132
Deorphanisation of G protein-coupled receptors : a tool to provide new insights in nervous system pathophysiology and new targets for psycho-active drugs 130
Expression pattern of GPR17, a dual receptor for uracil nucleotides and cysteinyl-leukotrienes, during brain ischemia in mice 126
Comparison and optimization of transient transfection methods at human astrocytoma cell line 1321N1 126
Mir-125a-3p negatively regulates oligodendrocyte precursor cells maturation and is altered in human multiple sclerosis 126
Regulation of oligodendrocyte functions : targeting lipid metabolism and extracellular matrix for myelin repair 126
Dysregulation of GPR17, a key receptor involved in NG2 progenitor cells differentiation to mature oligodendrocytes, as a novel potential pathogenetic mechanism in demyelinating diseases 125
Lupin Peptide T9 (GQEQSHQDEGVIVR) Modulates the Mutant PCSK9D374Y Pathway : in vitro Characterization of its Dual Hypocholesterolemic Behavior 125
Microglia is a key player in the reduction of stroke damage promoted by the new antithrombotic agent ticagrelor 124
Dysregulation of the GPR17 receptor in neuroinflammatory diseases: implications for remyelination in multiple sclerosis 124
Opposte effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes 123
Agonist-induced desensitization/resensitization of human GPR17 : a functional cross-talk between purinergic and cysteinyl-leukotriene ligands 120
Local dysregulation of the GPR17 receptor in neuroinflammatory diseases: implications for remyelination in multiple sclerosis 119
Extracellular purine and pyrimidine nucleotides as local extrinsic regulators of adult neural progenitor cells in the diseased CNS 118
Pharmacological and biotechnological in vitro approaches unveil the role of GPR17 signaling in regulating the timing of oligodendroglial differentiation 114
Role of the P2Y-like receptor GPR17 in neural precursor cells 114
Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury 113
Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways? 112
New mechanisms regulating myelination in the central nervous system : the role of GPR17 and of a novel micro-RNA 112
GPR17-expressing oligodendrocyte precursor cells differentially react to damage in experimental autoimmune encephalomyelitis and cuprizone-induced demyelination 111
Purinergic transmission in brain tumors and its impact on drug development 108
Uracil nucleotides : from metabolic intermediates to neuroprotection and neuroinflammation 107
Biotechnological and pharmacological in vitro approaches unveil the role of GPR17 signaling in regulating the timing of oligodendroglial differentiation 107
Involvement of GPR17, a dual receptor for uracil nucleotides and cysteinyl-leukotrienes, in brain ischemia in mice 106
Pathophysiological Role of Purines and Pyrimidines in Neurodevelopment: Unveiling New Pharmacological Approaches to Congenital Brain Diseases 106
The oral reversibly-binding antiplatelet agent, Ticagrelor, acts as an antagonist at the P2Y-like receptor GPR17 105
Gene regulation of the P2Y-like receptor GPR17 in oligodendrocytes, and pathological alterations in a mouse model of multiple sclerosis 105
SNX27 regulates GPR17 recycling and the kinetics of oligodendrocyte differentiation 105
Gene regulation of the P2Y-like receptor GPR17, a key player in oligodendroglial differentiation 104
Frontal Affinity Chromatography-Mass Spectrometry Useful for Characterization of New Ligands for GPR17 Receptor 104
GPR17, a key receptor involved in oligodendrogenesis: implications for re-myelination strategies 104
The P2Y-like GPR17 receptor orchestrates the transition between immature and myelinating oligodendrocytes and is a new target for myelin repair 102
Role of purinergic signalling in neuro-immune cells and adult neural progenitors 102
Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation 102
Gene regulation of the receptor GPR17 in oligodendroglial cells: expression pattern and pathological alterations in a mouse model of multiple sclerosis 101
P2Y receptors in GtoPdb v.2021.3 101
The P2Y-like GPR17 receptor regulates the differentiation of NG2+ neural precursor cells into mature oligodendrocytes 100
Promoting re-myelination in MS via the GPR17 receptor, a new key actor in oligodendrogenesis 100
Functional cross-talk between GPR17 and nerve growth factor in neuronal pheocromocytoma PC12 cell proliferation and differentiation 98
SNX27 regulation of GPR17 recycling is important for the correct differentiation of oligodendrocytes 98
SNX27, a protein of the retromer complex, regulates GPR17 recycling and the kinetics of oligodendrocyte differentiation 95
Identification of CRYAB+ KCNN3+ SOX9+ Astrocyte-Like and EGFR+ PDGFRA+ OLIG1+ Oligodendrocyte-Like Tumoral Cells in Diffuse IDH1-Mutant Gliomas and Implication of NOTCH1 Signalling in Their Genesis 94
Regulation of PC12 cell survival and differentiation by the new P2Y-like receptor GPR17 93
The mammalian target of rapamycin (mTOR) controls oligodendrocyte maturation by fine-tuning the activity of GPR17 receptor via G protein-coupled receptor kinases 93
A PDZ binding motif controls G protein-coupled receptor 17 trafficking in differentiating oligodendrocytes 93
GPR17 ligands : synthesis and characterization of new potent agonists 92
The P2Y-like receptor GPR17 as a potential target for the modulation of adult oligodendrogliogenesis 92
Oligodendrogenesis: focus on G protein-coupled receptor 17 (GPR17) 92
A new miRNA regulating oligodendrocyte maturation in physiology and disease 92
Time-dependent and critical role of the P2Y-like GPR17 receptor at distinct stages of oligodendrocyte differentiation 91
Purinergic and cysteinyl-leukotriene agonists of the GPR17 receptor engender distinct intracellular signalling programs with different functional potentials in oligodendrocyte maturation 91
Time-dependent and critical role of the P2Y-like GPR17 receptor at distinct stages of oligodendrocyte differentiation 90
Identification of molecular mechanisms underlying oligodendrocyte differentiation 87
Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death 86
In search of signals that trigger GPR17 expression in microglia cells 86
The genetic inhibition of GPR17 affects myelination by influencing important players in oligodendrocyte maturation, including purinergic receptors 85
Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor 83
Agonist-induced desensitisation/resensitisation of human GPR17: a functional cross talk between purinergic and cysteinyl-leukotriene ligands 81
P2Y receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database 80
Role of the P2Y-like receptor in neural precursor cells 79
Identification of novel potential B4GALT6 inhibitors through a large scale virtual screening 77
Gene regulation of GPR17, a checkpoint receptor in oligodendroglial differentiation 76
Ventral tegmental area/substantia nigra and prefrontal cortex rodent organotypic brain slices as an integrated model to study the cellular changes induced by oxygen/glucose deprivation and reperfusion : effect of neuroprotective agents 73
Totale 15.759
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Categoria #
all - tutte 50.967
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 50.967
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.257 0 0 0 0 117 216 218 109 233 204 84 76
2020/20211.966 131 121 99 66 171 193 101 138 263 213 374 96
2021/20222.781 185 124 121 147 256 231 284 200 196 384 300 353
2022/20232.122 308 170 203 227 213 361 60 122 226 39 109 84
2023/20242.132 91 101 165 195 357 138 102 209 103 146 262 263
2024/20251.184 181 347 148 282 226 0 0 0 0 0 0 0
Totale 16.624