Inflamm-aging refers to the chronic low-grade inflammation that occurs with aging and cellular senescence, and it is linked to various diseases. Understanding the markers involved in inflammation and aging, as well as their interaction with environmental factors and bodily control mechanisms, can provide crucial tools for assessing the resilience (i.e. the ability to adapt and improve) of the human body, particularly in the presence of chronic degenerative conditions or vulnerable life stages, that place the individual and the community to which he belongs in a state of potential fragility. HEBE focuses on physical exercise, along with nutritional and lifestyle recommendations, to reduce systemic inflammation and promote healthy aging. HEBE encompasses multiple research lines (LR). In the ongoing LR1 (“proof of concept”), healthy lifestyle recommendations were provided to University of Milan employees, and changes in quality of life and well-being were assessed using a specialized questionnaire. The first 100 eligible subjects, who expressed their willingness to participate, underwent a personalized physical exercise protocol based on clinical and objective assessments. Biomedical samples were collected at baseline (T0) and follow-up (T1) to establish a shared biobank and identify non-invasive biomarkers that monitor the impact of physical exercise on individual characteristics such as cardiovascular and metabolic health. Subsequently (LR2-LR10), the proof of concept findings will be expanded to include various conditions of vulnerability such as obesity, cancer, endocrine disorders, cardiovascular diseases, infertility, functional syndromes, respiratory disorders, neurodegenerative diseases, and autoimmune conditions. The research lines will leverage the expertise of the 94 participating investigators to form a collaborative network that maximizes the potential for investigation and knowledge exchange. This approach fosters a culture of health promotion and disease prevention.

HEBE project: Healthy aging versus inflamm-aging: The role of physical exercise in modulating the biomarkers of age-associated and environmentally determined chronic diseases, study protocol / F. Bianchi, E. Biganzoli, V. Bollati, M. Clerici, D. Lucini, C. Mando, F. Rota, F. Ambrogi, B. Arosio, M. Aureli, G. Baron, M. Baruscotti, C. Battaglia, C. Bellocchi, S. Bellosta, C. Bernardelli, G. Bernardelli, M. Bonomi, F. Bravi, P. Brocca, A.L. Brucato, A. Bucchi, M. Camera, N. Caporale, G. Cappelletti, L. Casati, S. Castaldi, S. Castiglioni, M.G. Cattaneo, R. Cazzola, S. Centanni, I. Cetin, R. Chiaramonte, I. Chiodini, E. Chiricozzi, P. Ciana, V. Citro, C.B. Cogliati, S.L. Corbetta, F. D'Addio, A. D'Amato, C.M.L. Dallanoce, M.V. DEI CAS, E. DEL FAVERO, A. DELLE FAVE, G. DIAS RODRIGUES, V.C. Edefonti, C. Fenizia, L. Ferrari, M. Ferraroni, P. Fiorina, D.M.M. Fornasari, M. Fumagalli, N. Gagliano, E.R. Galliera, J.A.E. Geginat, D. Giannandrea, F.A. Ingegnoli, C.A.M. LA PORTA, C.V.B. LA VECCHIA, D. Lecca, E.A. Lesma, P. Limonta, C. Loretelli, V. Martini, C. Matera, N. Montano, L. Pantoni, N. Papini, R.C. Paroni, C. Perego, L. Persani, A.S. Pistocchi, N. Platonova, G. Podda, P.T. Rise', P.V. Riva, A.M. Rizzo, V.M. Rondelli, M. Rossi, M. Ruscica, V.M. Savasi, M. Scavone, L. Sfondrini, L. Sironi, M. Sommariva, G. Testa, E. Tobaldini, C.A. Tringali, E. Verduci, M. Vicenzi, C.A. Vigano', G. Vistoli, G. Vitale. - In: PLOS ONE. - ISSN 1932-6203. - 19:4(2024), pp. e0300011.1-e0300011.14. [10.1371/journal.pone.0300011]

HEBE project: Healthy aging versus inflamm-aging: The role of physical exercise in modulating the biomarkers of age-associated and environmentally determined chronic diseases, study protocol

F. Bianchi;E. Biganzoli
;
V. Bollati;M. Clerici
;
D. Lucini;C. Mando;F. Rota;F. Ambrogi;B. Arosio;M. Aureli;G. Baron;M. Baruscotti;C. Battaglia;C. Bellocchi;S. Bellosta;C. Bernardelli;G. Bernardelli;M. Bonomi;F. Bravi;P. Brocca;A.L. Brucato;A. Bucchi;M. Camera;N. Caporale;G. Cappelletti;L. Casati;S. Castaldi;S. Castiglioni;M.G. Cattaneo;R. Cazzola;S. Centanni;I. Cetin;R. Chiaramonte;I. Chiodini;E. Chiricozzi;P. Ciana;V. Citro;C.B. Cogliati;S.L. Corbetta;F. D'Addio;A. D'Amato;C.M.L. Dallanoce;M.V. DEI CAS;E. DEL FAVERO;A. DELLE FAVE;G. DIAS RODRIGUES;V.C. Edefonti;C. Fenizia;L. Ferrari;M. Ferraroni;P. Fiorina;D.M.M. Fornasari;M. Fumagalli;N. Gagliano;E.R. Galliera;J.A.E. Geginat;D. Giannandrea;F.A. Ingegnoli;C.A.M. LA PORTA;C.V.B. LA VECCHIA;D. Lecca;E.A. Lesma;P. Limonta;C. Loretelli;V. Martini;C. Matera;N. Montano;L. Pantoni;N. Papini;R.C. Paroni;C. Perego;L. Persani;A.S. Pistocchi;N. Platonova;G. Podda;P.T. Rise';P.V. Riva;A.M. Rizzo;V.M. Rondelli;M. Rossi;M. Ruscica;V.M. Savasi;M. Scavone;L. Sfondrini;L. Sironi;M. Sommariva;G. Testa;E. Tobaldini;C.A. Tringali;E. Verduci;M. Vicenzi;C.A. Vigano';G. Vistoli;G. Vitale
2024

Abstract

Inflamm-aging refers to the chronic low-grade inflammation that occurs with aging and cellular senescence, and it is linked to various diseases. Understanding the markers involved in inflammation and aging, as well as their interaction with environmental factors and bodily control mechanisms, can provide crucial tools for assessing the resilience (i.e. the ability to adapt and improve) of the human body, particularly in the presence of chronic degenerative conditions or vulnerable life stages, that place the individual and the community to which he belongs in a state of potential fragility. HEBE focuses on physical exercise, along with nutritional and lifestyle recommendations, to reduce systemic inflammation and promote healthy aging. HEBE encompasses multiple research lines (LR). In the ongoing LR1 (“proof of concept”), healthy lifestyle recommendations were provided to University of Milan employees, and changes in quality of life and well-being were assessed using a specialized questionnaire. The first 100 eligible subjects, who expressed their willingness to participate, underwent a personalized physical exercise protocol based on clinical and objective assessments. Biomedical samples were collected at baseline (T0) and follow-up (T1) to establish a shared biobank and identify non-invasive biomarkers that monitor the impact of physical exercise on individual characteristics such as cardiovascular and metabolic health. Subsequently (LR2-LR10), the proof of concept findings will be expanded to include various conditions of vulnerability such as obesity, cancer, endocrine disorders, cardiovascular diseases, infertility, functional syndromes, respiratory disorders, neurodegenerative diseases, and autoimmune conditions. The research lines will leverage the expertise of the 94 participating investigators to form a collaborative network that maximizes the potential for investigation and knowledge exchange. This approach fosters a culture of health promotion and disease prevention.
inflammaging; lifestyle; HEBE; biomarkers
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
Settore MED/01 - Statistica Medica
Settore M-EDF/01 - Metodi e Didattiche delle Attivita' Motorie
Settore MED/44 - Medicina del Lavoro
Settore MED/04 - Patologia Generale
Settore BIO/17 - Istologia
2024
Article (author)
File in questo prodotto:
File Dimensione Formato  
HEBE project_Healthy aging versus inflamm-aging_The role of physical exercise in modulating the biomarkers of age-associated and environmentally determined chronic diseases, study protocol.pdf

accesso aperto

Descrizione: Study Protocol
Tipologia: Publisher's version/PDF
Dimensione 1.09 MB
Formato Adobe PDF
1.09 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1048948
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact