POLO, SIMONA LAURA ANNA
POLO, SIMONA LAURA ANNA
Dipartimento di Oncologia ed Emato-Oncologia
Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4
2025 E. Maspero, A. Cappa, J. Weber, P. Trifiro, R. Amici, A. Bruno, G. Faga, V. Cecatiello, R. Fattori, B. Leuzzi, V. Taibi, G. Meroni, M. Pasi, A. Romussi, L. Sartori, M. Villa, S. Vultaggio, M. Ciro, P. Soffientini, L. Lombardo, S. Dahe, A. Bachi, M. Varasi, M. Rossi, S. Pasqualato, C. Mercurio, S. Polo
The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells
2025 A. Lauriola, J.H. Enrique Steinberg, M. Sarubo, E. Maspero, F.A. Rossi, Y. Mouri, M. Pedretti, M. Hajisadeghian, V. Taibi, A. Vettori, N. Vitulo, M. Assfalg, M. D'Onofrio, M. Rossi, A. Yasue, A. Astegno, S. Polo, S. Santi, Y. Kudo, D. Guardavaccaro
Deconstructing destruction: A rapid route to proteasomal fate
2025 E. Maspero, S. Polo
Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
2024 P. Gahlot, B. Kravic, G. Rota, J. van den Boom, S. Levantovsky, N. Schulze, E. Maspero, S. Polo, C. Behrends, H. Meyer
A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements
2024 S. Martin, S. Scorzoni, S. Cordone, A. Mazzagatti, G.V. Beznoussenko, A.L. Gunn, M. Di Bona, Y. Eliezer, G. Leor, T. Ben-Yishay, A. Loffreda, V. Cancila, M.C. Rainone, M.R. Ippolito, V. Martis, F. Bedin, M. Garrè, L.P. Vaites, P. Vasapolli, S. Polo, D. Parazzoli, C. Tripodo, A.A. Mironov, A. Cuomo, U. Ben-David, S.F. Bakhoum, E.M. Hatch, P. Ly, S. Santaguida
BioE3 identifies specific substrates of ubiquitin E3 ligases
2023 O. Barroso-Gomila, L. Merino-Cacho, V. Muratore, C. Perez, V. Taibi, E. Maspero, M. Azkargorta, I. Iloro, F. Trulsson, A.C.O. Vertegaal, U. Mayor, F. Elortza, S. Polo, R. Barrio, J.D. Sutherland
A planar polarized MYO6-DOCK7-RAC1 axis promotes tissue fluidification in mammary epithelia
2023 L. Menin, J. Weber, S. Villa, E. Martini, E. Maspero, C.A. Niño, V. Cancila, A. Poli, P. Maiuri, A. Palamidessi, E. Frittoli, F. Bianchi, C. Tripodo, K.J. Walters, F. Giavazzi, G. Scita, S. Polo
Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1
2022 E. Magistrati, G. Maestrini, C.A. Nino, M. Lince-Faria, G. Beznoussenko, A. Mironov, E. Maspero, M. Bettencourt-Dias, S. Polo
The NEDD4 ubiquitin E3 ligase: A snapshot view of its functional activity and regulation
2022 D. Sicari, J. Weber, E. Maspero, S. Polo
Recurrent Spliceosome Mutations in Cancer: Mechanisms and Consequences of Aberrant Splice Site Selection
2022 C.A. Nino, R.S. Di Perrotolo, S. Polo
Myomics : myosin VI structural and functional plasticity
2021 E. Magistrati, S. Polo
The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress
2021 F. Napoletano, G. Ferrari Bravo, I.A.P. Voto, A. Santin, L. Celora, E. Campaner, C. Dezi, A. Bertossi, E. Valentino, M. Santorsola, A. Rustighi, V. Fajner, E. Maspero, F. Ansaloni, V. Cancila, C.F. Valenti, M. Santo, O.B. Artimagnella, S. Finaurini, U. Gioia, S. Polo, R. Sanges, C. Tripodo, A. Mallamaci, S. Gustincich, F. d'Adda di Fagagna, F. Mantovani, V. Specchia, G. Del Sal
Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles
2021 V. Fajner, F. Giavazzi, S. Sala, A. Oldani, E. Martini, F. Napoletano, D. Parazzoli, G. Cesare, R. Cerbino, E. Maspero, T. Vaccari, S. Polo
Listeria monocytogenes exploits host caveolin for cell-to-cell spreading
2020 A.S. Dhanda, C. Yu, K.T. Lulic, A.W. Vogl, V. Rausch, D. Yang, B.J. Nichols, S.H. Kim, S. Polo, C.G. Hansen, J.A. Guttman
USP25 regulates EGFR fate by modulating EGF-induced ubiquitylation dynamics
2020 C.A. Nino, N. Wollscheid, G. Giangreco, E. Maspero, S. Polo
The ubiquitin ligase Hecw controls oogenesis and neuronal homeostasis by promoting the liquid state of ribonucleoprotein particles
2020 V. Fajner, F. Giavazzi, S. Sala, A. Oldani, E. Martini, F. Napoletano, D. Parazzoli, R. Cerbino, E. Maspero, T. Vaccari, S.L.A. Polo
Selectivity of the CUBAN domain in the recognition of ubiquitin and NEDD8
2019 L. Castagnoli, W. Mandaliti, R. Nepravishta, E. Valentini, A. Mattioni, R. Procopio, M. Iannuccelli, S. Polo, M. Paci, G. Cesareni, E. Santonico
HECT E3 Ligases : a Tale With Multiple Facets
2019 J. Weber, S. Polo, E. Maspero
Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension
2019 M. Biancospino, G.R. Buel, C.A. Nino, E. Maspero, R.S. di Perrotolo, A. Raimondi, L. Redlingshofer, J. Weber, F.M. Brodsky, K.J. Walters, S. Polo
Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling
2019 R. Pascolutti, V. Algisi, A. Conte, A. Raimondi, M. Pasham, S. Upadhyayula, R. Gaudin, T. Maritzen, E. Barbieri, G. Caldieri, C. Tordonato, S. Confalonieri, S. Freddi, M.G. Malabarba, E. Maspero, S. Polo, C. Tacchetti, V. Haucke, T. Kirchhausen, P.P. Di Fiore, S. Sigismund