Due to its fundamental role in all eukaryotic cells, a deeper understanding of the molecular mechanisms underlying ubiquitination is of central importance. Being responsible for chain specificity and substrate recognition, E3 ligases are the selective elements of the ubiquitination process. In this review, we discuss different cellular pathways regulated by one of the first identified E3 ligase, NEDD4, focusing on its pathophysiological role, its known targets and modulators. In addition, we highlight small molecule inhibitors that act on NEDD4 and discuss new strategies to effectively target this E3 enzyme.
The NEDD4 ubiquitin E3 ligase: A snapshot view of its functional activity and regulation / D. Sicari, J. Weber, E. Maspero, S. Polo. - In: BIOCHEMICAL SOCIETY TRANSACTIONS. - ISSN 0300-5127. - 50:1(2022 Feb 07), pp. 473-485. [10.1042/BST20210731]
The NEDD4 ubiquitin E3 ligase: A snapshot view of its functional activity and regulation
E. Maspero
Penultimo
;S. Polo
Ultimo
2022
Abstract
Due to its fundamental role in all eukaryotic cells, a deeper understanding of the molecular mechanisms underlying ubiquitination is of central importance. Being responsible for chain specificity and substrate recognition, E3 ligases are the selective elements of the ubiquitination process. In this review, we discuss different cellular pathways regulated by one of the first identified E3 ligase, NEDD4, focusing on its pathophysiological role, its known targets and modulators. In addition, we highlight small molecule inhibitors that act on NEDD4 and discuss new strategies to effectively target this E3 enzyme.
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