Data from pre-clinical and clinical studies provide evidence that colony-stimulating factors (CSFs) and other growth factors (GFs) can improve stroke outcome by reducing stroke damage through their anti-apoptotic and anti-inflammatory effects, and by promoting angiogenesis and neurogenesis. This review provides a critical and up-to-date literature review on CSF use in stroke. We searched for experimental and clinical studies on haemopoietic GFs such as granulocyte CSF, erythropoietin, granulocyte-macrophage colony-stimulating factor, stem cell factor (SCF), vascular endothelial GF, stromal cell-derived factor-1α and SCF in ischemic stroke. We also considered studies on insulin-like growth factor-1 and neurotrophins. Despite promising results from animal models, the lack of data in human beings hampers efficacy assessments of GFs on stroke outcome. We provide a comprehensive and critical view of the present knowledge about GFs and stroke, and an overview of ongoing and future prospects.
Growth factors in ischemic stroke / S. Lanfranconi, F. Locatelli, S. Corti, L. Candelise, G. P. Comi, P. L. Baron, S. Strazzer, N. Bresolin, A. Bersano. - In: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. - ISSN 1582-1838. - 15:8(2011 Aug), pp. 1645-1687.
|Titolo:||Growth factors in ischemic stroke|
LANFRANCONI, SILVIA (Primo)
BRESOLIN, NEREO (Penultimo)
BERSANO, ANNA (Ultimo)
|Parole Chiave:||Rats ; Animals ; Granulocyte Colony-Stimulating Factor ; Granulocyte-Macrophage Colony-Stimulating Factor ; Humans ; Stroke ; Brain ; Brain Ischemia ; Mice ; Intercellular Signaling Peptides and Proteins|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||ago-2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1582-4934.2009.00987.x|
|Appare nelle tipologie:||01 - Articolo su periodico|