Differences in Fusarium musae genomes

Fusarium musae has recently been described as a cross-kingdom pathogen causing crown rot of banana, a post-harvest disease, keratitis and skin infections as well as systemic infections in immunocompromised patients. To better understand the diversity within strains of the species, the entire genome of 19 Fusarium musae strains was obtained through Illumina and Nanopore sequencing assembling short and long reads. The length of the assembled nuclear DNA ranged from 43.04 Mbp to 45.54 Mbp. A similar divergence is shown in mitochondrial DNA ranging from 56493 bp to 59256 bp. Comparative analysis revealed differences in number of secondary metabolites gene clusters (from 41 to 47). A special focus on Enniatin-Beauvericin cluster in F. musae identified evolutionary divergences of NPRS gene within the species. Our results are a fundamental step to better investigate phylogenetic relationship within F. musae strains with diverse origin and will provide essential knowledge for functional studies of genes involved in the environmental adaptation and in the infection process on humans and banana fruit.