SAPONARO, ANDREA COSIMO
SAPONARO, ANDREA COSIMO
Dipartimento di Scienze Farmacologiche e Biomolecolari Rodolfo Paoletti
Combining elastic network models and linear response theory as tool to understand the global dynamics in allosteric regulation of HCN channels
2026 M. Behringer, J. Krumbach, A. Porro, A. Saponaro, D. Difrancesco, A. Moroni, K. Hamacher, G. Thiel
TRIP8bnano peptide prevents cAMP binding to HCN2 channels alleviating pain-like behaviors in rats with neuropathic pain
2026 S. I Loya-Lopez, K. Gomez, A. Porro, G. Thiel, A. Moroni, H. N Allen, R. Khanna, A. Saponaro
Structure mirroring function: What's the ‘matter’ with the funny current?
2025 A. Saponaro, D. Difrancesco
Extracellular activation of HCN4 by a subtype-specific nanobody
2025 A. Sadat Sharifzadeh, R. Castelli, A. Porro, P. Mesirca, R. Perrier, A. M Gómez, N. Mekrane, H. Benoit, A. C Meli, L.M. G Palloni, D. Difrancesco, M. E Mangoni, G. Thiel, A. Saponaro, A. Moroni
Structural determinants of ivabradine block of the open pore of HCN4
2024 A. Saponaro, J.H. Krumbach, A. Chaves-Sanjuan, A.S. Sharifzadeh, A. Porro, R. Castelli, K. Hamacher, M. Bolognesi, D. Difrancesco, O.B. Clarke, G. Thiel, A. Moroni
A high affinity switch for cAMP in the HCN pacemaker channels
2024 A. Porro, A. Saponaro, R. Castelli, B. Introini, A.H. Alkotob, G. Ranjbari, U. Enke, J. Kusch, K. Benndorf, B. Santoro, D. Difrancesco, G. Thiel, A. Moroni
A Photoactivatable Version of Ivabradine Enables Light-Induced Block of HCN Current In Vivo
2024 A. Porro, E. Armano, F. Brandalise, R. Appiani, M. Beltrame, A. Saponaro, C. Dallanoce, K. Nakajo, K. Ryu, R. Leone, G. Thiel, M. Pallavicini, A. Moroni, C. Bolchi
Structural determinant of the Ivabradine-induced block of pacemaker HCN channels
2023 A. Saponaro, A. Porro, J. Wissmann, A.S. Sharifzadeh, A. Chaves-Sanjuan, D. Difrancesco, K. Hamacher, G. Thiel, A. Moroni
Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block
2023 J. Krumbach, D. Bauer, A.S. Sharifzadeh, A. Saponaro, R. Lautenschläger, K. Lange, O. Rauh, D. Difrancesco, A. Moroni, G. Thiel, K. Hamacher
Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels
2022 J.L. Carvalho-de-Souza, A. Saponaro, C.A.Z. Bassetto, O. Rauh, I. Schroeder, F. Franciolini, L. Catacuzzeno, F. Bezanilla, G. Thiel, A. Moroni
Editorial: The key role of lipids in the regulation of ion channels
2022 A. Saponaro, M. Lolicato
Validation of the binding stoichiometry between HCN channels and their neuronal regulator TRIP8b by single molecule measurements
2022 A. Saponaro, F. Vallese, A. Porro, O.B. Clarke
Gating movements and ion permeation in {HCN}4 pacemaker channels
2021 A.C. Saponaro, D. Bauer, M. Hunter Giese, P. Swuec, A. Porro, F. Gasparri, A. Sadat Sharifzadeh, A. CHAVES SANJUAN, L. Alberio, G. Parisi, G. Cerutti, O.B. Clarke, K. Hamacher, H.M. Colecraft, F. Mancia, W.A. Hendrickson, S.A. Siegelbaum, D. DI FRANCESCO, M. Bolognesi, G. Thiel, B. Santoro, A. Moroni
Detection of ligand binding to purified HCN channels using fluorescence-based size exclusion chromatography
2021 A. Saponaro, A.S. Sharifzadeh, A. Moroni
Structural and functional approaches to studying cAMP regulation of HCN channels
2021 A. Saponaro, G. Thiel, A. Moroni
Rational design of a mutation to investigate the role of the brain protein TRIP8b in limiting the cAMP response of HCN channels in neurons
2020 A.C. Saponaro, A. Porro, A. Binda, I. Rivolta, M. Pisoni, C. Donadoni
Understanding Docking Complexes of Macromolecules Using HADDOCK: The Synergy between Experimental Data and Computations
2020 A.C. Saponaro, V. Maione, A. Bonvin, F. Cantini
Cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4
2020 A. Porro, G. Thiel, A. Moroni, A.C. Saponaro
A functional K+ channel from tetraselmis virus 1, a member of the mimiviridae
2020 K. Kukovetz, B. Hertel, C.R. Schvarcz, A. Saponaro, M. Manthey, U. Burk, T. Greiner, G.F. Steward, J.L. van Etten, A. Moroni, G. Thiel, O. Rauh
Structural Basis of Inhibition of the Pioneer Transcription Factor NF-Y by Suramin
2020 V. Nardone, A. Chaves-Sanjuan, M. Lapi, C. Airoldi, A. Saponaro, S. Pasqualato, D. Dolfini, C. Camilloni, A. Bernardini, N. Gnesutta, R. Mantovani, M. Nardini