PORRO, ALESSANDRO
PORRO, ALESSANDRO
Dipartimento di Bioscienze
A Photoactivatable Version of Ivabradine Enables Light-Induced Block of HCN Current In Vivo
2024 A. Porro, E. Armano, F. Brandalise, R. Appiani, M. Beltrame, A. Saponaro, C. Dallanoce, K. Nakajo, K. Ryu, R. Leone, G. Thiel, M. Pallavicini, A. Moroni, C. Bolchi
Structural determinants of ivabradine block of the open pore of HCN4
2024 A. Saponaro, J.H. Krumbach, A. Chaves-Sanjuan, A.S. Sharifzadeh, A. Porro, R. Castelli, K. Hamacher, M. Bolognesi, D. Difrancesco, O.B. Clarke, G. Thiel, A. Moroni
Design of a photo-activatable ivabradine to enable light induced block of HCN current in tissues
2023 A. Porro, C. Bolchi, F. Brandalise, R. Appiani, R. Leone, F. Thei, G. Thiel, M. Pallavicini, A. Moroni
Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy
2022 A. Merseburg, J. Kasemir, E.W. Buss, F. Leroy, T. Bock, A. Porro, A. Barnett, S.E. Tröder, B. Engeland, M. Stockebrand, A. Moroni, S.A. Siegelbaum, D. Isbrandt, B. Santoro
Do the functional properties of HCN1 mutants correlate with the clinical features in epileptic patients?
2021 A. Porro, G. Abbandonato, V. Veronesi, A. Russo, A. Binda, L. Antolini, T. Granata, B. Castellotti, C. Marini, A. Moroni, J.C. Difrancesco, I. Rivolta
Gating movements and ion permeation in {HCN}4 pacemaker channels
2021 A.C. Saponaro, D. Bauer, M. Hunter Giese, P. Swuec, A. Porro, F. Gasparri, A. Sadat Sharifzadeh, A. CHAVES SANJUAN, L. Alberio, G. Parisi, G. Cerutti, O.B. Clarke, K. Hamacher, H.M. Colecraft, F. Mancia, W.A. Hendrickson, S.A. Siegelbaum, D. DI FRANCESCO, M. Bolognesi, G. Thiel, B. Santoro, A. Moroni
Rational design of a mutation to investigate the role of the brain protein TRIP8b in limiting the cAMP response of HCN channels in neurons
2020 A.C. Saponaro, A. Porro, A. Binda, I. Rivolta, M. Pisoni, C. Donadoni
Cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4
2020 A. Porro, G. Thiel, A. Moroni, A.C. Saponaro
HCN DOMAIN: A KEY REGULATOR OF HCN CHANNEL GATING
2019 A. Porro
Developing Synthetic Peptides to Regulate Native HCN Channels
2019 A. Saponaro, F. Cantini, A. Porro, A. Bucchi, D. Difrancesco, V. Maione, M. Laskowski, P. Mesirca, M. Mangoni, G. Thiel, L. Banci, B. Santoro, A. Moroni
The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels
2019 A. Porro, A. Saponaro, F. Gasparri, D. Bauer, C. Gross, M. Pisoni, G. Abbandonato, K. Hamacher, B. Santoro, G. Thiel, A. Moroni
Assigning Function to the D and E Helices of HCN CNBD
2018 A. Saponaro, A. Porro, C. Donadoni, B. Santoro, G. Thiel, A. Moroni
A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
2018 A. Saponaro, F. Cantini, A. Porro, A. Bucchi, D. Difrancesco, V. Maione, C. Donadoni, B. Introini, P. Mesirca, M.E. Mangoni, G. Thiel, L. Banci, B. Santoro, A. Moroni
A light-gated potassium channel for sustained neuronal inhibition
2018 L. Alberio, A. Locarno, A. Saponaro, E. Romano, V. Bercier, S. Albadri, F. Simeoni, S. Moleri, S. Pelucchi, A. Porro, E. Marcello, N. Barsotti, K. Kukovetz, A.J. Boender, A. Contestabile, S. Luo, A. Moutal, Y. Ji, G. Romani, M. Beltrame, F. Del Bene, M. Di Luca, R. Khanna, H.M. Colecraft, M. Pasqualetti, G. Thiel, R. Tonini, A. Moroni
Fusicoccin activates KAT1 channels by stabilizing their interaction with 14-3-3 proteins
2017 A. Saponaro, A. Porro, A. Chaves-Sanjuan, M. Nardini, O. Rauh, G. Thiel, A. Moroni
Exploring new pharmacological perspectives of Fusicoccin, a stabilizer of 14-3-3 – target protein complex
2017 A. Saponaro, A. Porro, A.C. Sanjuan, B. Introini, M. Nardini, G. Thiel, A. Moroni