Biological ion channels precisely control the flow of ions across membranes in response to a range of physical and chemical stimuli. With their ability of transporting ions in a highly selective manner and of integrating regulatory cues, they are a source of inspiration for the construction of solid-state nanopores as sensors or switches for practical applications. Here, we summarize recent advancements in understanding the mechanisms of ion permeation and gating in channel proteins with a focus on the elementary steps of ion transport through the pore and on non-canonical modes of intramolecular communication between peripheral sensory domains and the central channel pore.
Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels / J.L. Carvalho-de-Souza, A. Saponaro, C.A.Z. Bassetto, O. Rauh, I. Schroeder, F. Franciolini, L. Catacuzzeno, F. Bezanilla, G. Thiel, A. Moroni. - In: ADVANCES IN PHYSICS: X. - ISSN 2374-6149. - 7:1(2022 Jan), pp. 1978317.1-1978317.24. [10.1080/23746149.2021.1978317]
Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels
A. SaponaroSecondo
;A. Moroni
Ultimo
2022
Abstract
Biological ion channels precisely control the flow of ions across membranes in response to a range of physical and chemical stimuli. With their ability of transporting ions in a highly selective manner and of integrating regulatory cues, they are a source of inspiration for the construction of solid-state nanopores as sensors or switches for practical applications. Here, we summarize recent advancements in understanding the mechanisms of ion permeation and gating in channel proteins with a focus on the elementary steps of ion transport through the pore and on non-canonical modes of intramolecular communication between peripheral sensory domains and the central channel pore.File | Dimensione | Formato | |
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