The use of Plant Food Supplements (PFS) has increased significantly in the last decades. The wide diffusion of these products has raised concerns about their safety and to solve at least some critical points the EU Project PlantLIBRA was financed. The project included among its goals the collection of adverse effects due to PFS; using different sources: 1) the scientific literature; 2) European Poison Centers; 3) the PlantLIBRA consumer survey. New data from the Pavia Poison Centre, ANSES and FDA were elaborated after the end of EU Project. Adverse effects were analysed according to the WHO causal relationship criteria. Valeriana officinalis and Camellia sinensis were the plants most frequently involved in adverse effects in European countries. Although mild/moderate symptomatology were generally described, some severe outcomes occurred, including fatal cases. Nervous and gastrointestinal systems were the main targets; the intestinal disorders were associated with fibres and polyphenols present in some plants.

Adverse effects to food supplements containing botanical ingredients / F. Colombo, C.M. DI LORENZO, S. Biella, S. Vecchio, G. Frigerio, P.A. Restani. - In: JOURNAL OF FUNCTIONAL FOODS. - ISSN 1756-4646. - 72:(2020), pp. 103990.1-103990.10. [10.1016/j.jff.2020.103990]

Adverse effects to food supplements containing botanical ingredients

F. Colombo
Primo
;
C.M. DI LORENZO
Secondo
;
S. Biella;G. Frigerio
Penultimo
;
P.A. Restani
Ultimo
2020

Abstract

The use of Plant Food Supplements (PFS) has increased significantly in the last decades. The wide diffusion of these products has raised concerns about their safety and to solve at least some critical points the EU Project PlantLIBRA was financed. The project included among its goals the collection of adverse effects due to PFS; using different sources: 1) the scientific literature; 2) European Poison Centers; 3) the PlantLIBRA consumer survey. New data from the Pavia Poison Centre, ANSES and FDA were elaborated after the end of EU Project. Adverse effects were analysed according to the WHO causal relationship criteria. Valeriana officinalis and Camellia sinensis were the plants most frequently involved in adverse effects in European countries. Although mild/moderate symptomatology were generally described, some severe outcomes occurred, including fatal cases. Nervous and gastrointestinal systems were the main targets; the intestinal disorders were associated with fibres and polyphenols present in some plants.
Botanicals; Plant Food Supplements; Adverse effects; Poison Centres; Prebiotic fibres
Settore CHIM/10 - Chimica degli Alimenti
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/931781
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