Magnesium (Mg2+) deficiency is probably the most underestimated electrolyte imbalance in Western countries. It is frequent in obese patients, subjects with type-2 diabetes and metabolic syndrome, both in adulthood and in childhood. This narrative review aims to offer insights into the pathophysiological mechanisms linking Mg2+ deficiency with obesity and the risk of developing metabolic syndrome and type 2 diabetes. Literature highlights critical issues about the treatment of Mg2+ deficiency, such as the lack of a clear definition of Mg2+ nutritional status, the use of different Mg2+ salts and dosage, and the different duration of the Mg2+ supplementation. Despite the lack of agreement, an appropriate dietary pattern, including the right intake of Mg2+, improves metabolic syndrome by reducing blood pressure, hyperglycemia, and hypertriglyceridemia. This occurs through the modulation of gene expression and proteomic profile as well as through a positive influence on the composition of the intestinal microbiota and the metabolism of vitamins B1 and D.

Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes / G. Piuri, M. Zocchi, M. Della Porta, V. Ficara, M. Manoni, G.V. Zuccotti, L. Pinotti, J.A. Maier, R. Cazzola. - In: NUTRIENTS. - ISSN 2072-6643. - 13:2(2021 Jan 22), pp. 320.1-320.16. [10.3390/nu13020320]

Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes

G. Piuri
Co-primo
;
M. Zocchi
Co-primo
;
M. Della Porta;V. Ficara;M. Manoni;G.V. Zuccotti;L. Pinotti;J.A. Maier
Penultimo
;
R. Cazzola
Ultimo
2021-01-22

Abstract

Magnesium (Mg2+) deficiency is probably the most underestimated electrolyte imbalance in Western countries. It is frequent in obese patients, subjects with type-2 diabetes and metabolic syndrome, both in adulthood and in childhood. This narrative review aims to offer insights into the pathophysiological mechanisms linking Mg2+ deficiency with obesity and the risk of developing metabolic syndrome and type 2 diabetes. Literature highlights critical issues about the treatment of Mg2+ deficiency, such as the lack of a clear definition of Mg2+ nutritional status, the use of different Mg2+ salts and dosage, and the different duration of the Mg2+ supplementation. Despite the lack of agreement, an appropriate dietary pattern, including the right intake of Mg2+, improves metabolic syndrome by reducing blood pressure, hyperglycemia, and hypertriglyceridemia. This occurs through the modulation of gene expression and proteomic profile as well as through a positive influence on the composition of the intestinal microbiota and the metabolism of vitamins B1 and D.
magnesium; magnesium deficiency; magnesium supplementation; obesity; metabolic syndrome; type 2 diabetes; gut microbiota; vitamin D
Settore BIO/10 - Biochimica
Settore MED/38 - Pediatria Generale e Specialistica
Settore MED/04 - Patologia Generale
Settore AGR/18 - Nutrizione e Alimentazione Animale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/810038
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