Arthrospira platensis (spirulina) is a cyanobacterium, which contains mainly two phycobiliproteins (PBP), i.e., C-phycocyanin (C-PC) and allophycocyanin (APC). In this study, PBP were hydrolyzed using trypsin, and the composition of the hydrolysate was characterized by HPLC-ESI-MS/MS. Furthermore, the potential anti-diabetic activity was assessed by using either biochemical or cellular techniques. Findings suggest that PBP peptides inhibit DPP-IV activity in vitro with a dose-response trend and an IC50 value falling in the range between 0.5 and 1.0 mg/mL. A lower inhibition of the DPP-IV activity expressed by Caco-2 cells was observed, which was explained by a secondary metabolic degradation exerted by the same cells.
Phycobiliproteins from Arthrospira Platensis (Spirulina): A New Source of Peptides with Dipeptidyl Peptidase-IV Inhibitory Activity / Y. Li, G. Aiello, C. Bollati, M. Bartolomei, A. Arnoldi, C. Lammi. - In: NUTRIENTS. - ISSN 2072-6643. - 12:3(2020 Mar).
Titolo: | Phycobiliproteins from Arthrospira Platensis (Spirulina): A New Source of Peptides with Dipeptidyl Peptidase-IV Inhibitory Activity |
Autori: | LI, YUCHEN (Primo) AIELLO, GILDA (Secondo) ARNOLDI, ANNA (Penultimo) LAMMI, CARMEN (Ultimo) (Corresponding) |
Settore Scientifico Disciplinare: | Settore CHIM/10 - Chimica degli Alimenti |
Progetto: | PIANO DI SOSTEGNO ALLA RICERCA 2015-2017 - LINEA 2 "DOTAZIONE ANNUALE PER ATTIVITA' ISTITUZIONALE" |
Data di pubblicazione: | mar-2020 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/nu12030794 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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