CONTEXT: Berries are a source of polyphenols with recognized health-promoting activities. Several studies suggest that consumption of berries may improve vascular function. OBJECTIVE: The aim of this systematic review is to provide evidence of short- and long-term benefits of berries on outcomes of vascular function. DATA SOURCES: Human intervention studies were collected from PubMed and Scopus databases. STUDY SELECTION: Studies were eligible if they investigated the effects of acute or chronic berry consumption on one or more markers of vascular function in humans and provided a characterization of the berry polyphenolic content. Only randomized controlled trials were included, and studies were excluded if berries were combined with other foods. DATA EXTRACTION: After selection, 22 randomized controlled trials were included and analyzed, most of which were performed in healthy individuals or patients with cardiovascular risk factors. RESULTS: The overall results seem to suggest a protective role of berries in vascular function, likely dependent on the time of exposure, the type and dose of berry, and the biomarkers analyzed. Flow-mediated dilation and reactive hyperemia index (markers of vascular reactivity) improved following short-term interventions, while pulse wave velocity and augmentation index (markers of arterial stiffness) improved only after medium- to long-term intervention. CONCLUSIONS: Current evidence suggests that berries, at physiological relevant doses, may have a role in the modulation of vascular function and stiffness. High-quality human intervention trials are encouraged in order to strengthen these findings and to better elucidate the mechanisms involved in such modulation.

Role of berries in vascular function : a systematic review of human intervention studies / D. Martini, M. Marino, D. Angelino, C. Del Bo', D. Del Rio, P. Riso, M. Porrini. - In: NUTRITION REVIEWS. - ISSN 0029-6643. - 78:3(2020 Mar), pp. 189-206. [10.1093/nutrit/nuz053]

Role of berries in vascular function : a systematic review of human intervention studies

D. Martini;M. Marino;C. Del Bo'
;
P. Riso;M. Porrini
2020

Abstract

CONTEXT: Berries are a source of polyphenols with recognized health-promoting activities. Several studies suggest that consumption of berries may improve vascular function. OBJECTIVE: The aim of this systematic review is to provide evidence of short- and long-term benefits of berries on outcomes of vascular function. DATA SOURCES: Human intervention studies were collected from PubMed and Scopus databases. STUDY SELECTION: Studies were eligible if they investigated the effects of acute or chronic berry consumption on one or more markers of vascular function in humans and provided a characterization of the berry polyphenolic content. Only randomized controlled trials were included, and studies were excluded if berries were combined with other foods. DATA EXTRACTION: After selection, 22 randomized controlled trials were included and analyzed, most of which were performed in healthy individuals or patients with cardiovascular risk factors. RESULTS: The overall results seem to suggest a protective role of berries in vascular function, likely dependent on the time of exposure, the type and dose of berry, and the biomarkers analyzed. Flow-mediated dilation and reactive hyperemia index (markers of vascular reactivity) improved following short-term interventions, while pulse wave velocity and augmentation index (markers of arterial stiffness) improved only after medium- to long-term intervention. CONCLUSIONS: Current evidence suggests that berries, at physiological relevant doses, may have a role in the modulation of vascular function and stiffness. High-quality human intervention trials are encouraged in order to strengthen these findings and to better elucidate the mechanisms involved in such modulation.
berries; endothelial function; intervention studies; (poly)phenols; systematic review; vascular function
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
mar-2020
31-lug-2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/669748
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