IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case-control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5' region were genotyped. No significant association was detected, although heterogeneity was noted for the 5' CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5' CNV.

No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis / F. Guerini, M. Clerici, R. Cagliani, S. Malhotra, X. Montalban, D. Forni, C. Agliardi, S. Riva, D. Caputo, D. Galimberti, R. Asselta, C. Fenoglio, E. Scarpini, G. Comi, N. Bresolin, M. Comabella, M. Sironi. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 271:1-2(2014 Jun 15), pp. 49-52.

No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis

M. Clerici;D. Galimberti;R. Asselta;C. Fenoglio;E. Scarpini;G. Comi;N. Bresolin;
2014

Abstract

IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case-control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5' region were genotyped. No significant association was detected, although heterogeneity was noted for the 5' CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5' CNV.
Settore MED/03 - Genetica Medica
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/245060
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact