N‐Amidinyl‐Benzodiazaborines as Novel Boron‐Based Scaffolds: Synthesis and Application in Retromer Stabilization

Diazaborines, a class of boron-containing compounds known for their antibacterial activity, are synthesized from 2-formylphenylboronic acid and hydrazines. Yet, the use of aminoguanidine has never been explored; thus, no examples of N-amidinyl-benzodiazaborines have been reported to date. Herein, we computationally and experimentally investigated the synthesis and characterization of novel N-amidinyl-benzodiazaborines, showing how these heteroaryl guanyl hydrazones are able to stabilize the retromer, a protein complex whose malfunction impairs the disposal of neurotoxic protein aggregates in neurodegenerative diseases such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS).