The permeability of the immature intestine is higher in newborns than in adults; a damaged gut barrier in young animals increases the susceptibility to digestive and infectious diseases later in life. It is therefore of major importance to avoid impairment of the intestinal barrier, specifically in a delicate phase of development, such as weaning. This study aimed to evaluate the effects of bovine colostrum supplementation on the intestinal barrier, such as the intestinal morphology and proliferation level and tight junctions expression (zonulin) and enteric nervous system (ENS) inflammation status (through the expression of PGP9.5 and GFAP) in fattening rabbits. Rabbits of 35 days of age were randomly divided into three groups (n = 13) based on the dietary administration: commercial feed (control group, CTR) and commercial feed supplemented with 2.5% and 5% bovine colostrum (BC1 and BC2 groups, respectively). Rabbits receiving the BC1 diet showed a tendency to have better duodenum morphology and higher proliferation rates (p < 0.001) than the control group. An evaluation of the zonulin expression showed that it was higher in the BC2 group, suggesting increased permeability, which was partially confirmed by the expression of GFAP. Our results suggest that adding 2.5% BC into the diet could be a good compromise between intestinal morphology and permeability, since rabbits fed the highest inclusion level of BC showed signs of higher intestinal permeability.

Intestine Health and Barrier Function in Fattening Rabbits Fed Bovine Colostrum / L. Aidos, M. Pallaoro, G. Mirra, V. Serra, M. Castrica, S. Agradi, G. Curone, D. Vigo, F. Riva, C.M. Balzaretti, R. De Bellis, G. Pastorelli, G. Brecchia, S.C. Modina, A. Di Giancamillo. - In: VETERINARY SCIENCES. - ISSN 2306-7381. - 10:11(2023 Nov 15), pp. 657.1-657.17. [10.3390/vetsci10110657]

Intestine Health and Barrier Function in Fattening Rabbits Fed Bovine Colostrum

L. Aidos
Primo
;
M. Pallaoro
Secondo
;
G. Mirra;V. Serra;M. Castrica;S. Agradi;G. Curone;D. Vigo;F. Riva;C.M. Balzaretti;G. Pastorelli;G. Brecchia;S.C. Modina
Penultimo
;
A. Di Giancamillo
Ultimo
2023

Abstract

The permeability of the immature intestine is higher in newborns than in adults; a damaged gut barrier in young animals increases the susceptibility to digestive and infectious diseases later in life. It is therefore of major importance to avoid impairment of the intestinal barrier, specifically in a delicate phase of development, such as weaning. This study aimed to evaluate the effects of bovine colostrum supplementation on the intestinal barrier, such as the intestinal morphology and proliferation level and tight junctions expression (zonulin) and enteric nervous system (ENS) inflammation status (through the expression of PGP9.5 and GFAP) in fattening rabbits. Rabbits of 35 days of age were randomly divided into three groups (n = 13) based on the dietary administration: commercial feed (control group, CTR) and commercial feed supplemented with 2.5% and 5% bovine colostrum (BC1 and BC2 groups, respectively). Rabbits receiving the BC1 diet showed a tendency to have better duodenum morphology and higher proliferation rates (p < 0.001) than the control group. An evaluation of the zonulin expression showed that it was higher in the BC2 group, suggesting increased permeability, which was partially confirmed by the expression of GFAP. Our results suggest that adding 2.5% BC into the diet could be a good compromise between intestinal morphology and permeability, since rabbits fed the highest inclusion level of BC showed signs of higher intestinal permeability.
intestinal barrier; rabbits; intestinal health; zonulin; enteric nervous system; bovine colostrum
Settore VET/01 - Anatomia degli Animali Domestici
Settore VET/02 - Fisiologia Veterinaria
Settore VET/04 - Ispezione degli Alimenti di Origine Animale
Settore VET/05 - Malattie Infettive degli Animali Domestici
Settore AGR/18 - Nutrizione e Alimentazione Animale
15-nov-2023
Article (author)
File in questo prodotto:
File Dimensione Formato  
vetsci-Aidos et al., 2023.pdf

accesso aperto

Descrizione: Article
Tipologia: Publisher's version/PDF
Dimensione 3.21 MB
Formato Adobe PDF
3.21 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/1032214
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 1
social impact