Background: Brain iron homeostasis is disrupted in neurodegeneration and areas of iron overload partially overlap with regions of amyloid and tau burden in Alzheimer's disease (AD). Previous studies demonstrated alterations in brain iron accumulation in AD using quantitative susceptibility mapping (QSM).Objective: Here, we investigate brain alterations of QSM values in AD and non-AD patients as compared to healthy controls (HC) in the superior temporal sulcus and its banks (BANKSSTS), one of the top AD-affected regions.Methods: Thirty-four patients who underwent brain MRI including a multi-echo gradient-echo sequence were subdivided into AD (n = 19) and non-AD (n = 15) groups according to their clinical profile, CSF (A beta(42/40)) and/or amyloid-PET status. Ten HC were also included. QSM values were extracted from left and right BANKSSTS and compared among groups. Correlation and binomial regression analyses between QSM values and CSF-AD biomarkers were conducted.Results: QSM in left BANKSSTS was significantly different among groups (p = 0.003, H= 11.40), being higher in AD. QSM values in left BANKSSTS were correlated with A beta(42) (rho -0.55, p = 0.005), A beta(42/40) (rho -0.66, p < 0.001), pTau (rho 0.63, p < 0.001), tTau (rho 0.56, p = 0.005), tTau/A beta(42) (rho 0.68, p < 0.001) and pTau/A beta(42) (rho 0.71, p < 0.001). No correlations between QSM values and amyloid-PET SUVR in the left BANKSSTS were found. QSM values in left BANKSSTS showed good accuracy in discriminating AD (AUC= 0.80, CI95% [0.66-0.93]). Higher QSM values were independent predictors of A beta(42) (B = 0.63, p = 0.032), A beta(42/40) (B = 0.81, p = 0.028), pTau (B = 0.96, p = 0.046), tTau (B = 0.55, p = 0.027), and tTau/A beta (42) (B = 1.13, p = 0.042) positivity.Conclusion: Our preliminary data support the potential role of increased QSM values in the left BANKSSTS as an auxiliary imaging biomarker in AD diagnosis.

Banks of the Superior Temporal Sulcus in Alzheimer's Disease: A Pilot Quantitative Susceptibility Mapping Study / L. Sacchi, V.E. Contarino, S. Siggillino, T. Carandini, G.G. Fumagalli, A.M. Pietroboni, M. Arcaro, C. Fenoglio, E. Orunesu, M. Castellani, S. Casale, G. Conte, C. Liu, F. Triulzi, D. Galimberti, E. Scarpini, A. Arighi. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 93:3(2023), pp. 1125-1134. [10.3233/JAD-230095]

Banks of the Superior Temporal Sulcus in Alzheimer's Disease: A Pilot Quantitative Susceptibility Mapping Study

L. Sacchi
Primo
;
T. Carandini;G.G. Fumagalli;A.M. Pietroboni;M. Arcaro;C. Fenoglio;E. Orunesu;M. Castellani;G. Conte;F. Triulzi;D. Galimberti;E. Scarpini
Penultimo
;
A. Arighi
Ultimo
2023

Abstract

Background: Brain iron homeostasis is disrupted in neurodegeneration and areas of iron overload partially overlap with regions of amyloid and tau burden in Alzheimer's disease (AD). Previous studies demonstrated alterations in brain iron accumulation in AD using quantitative susceptibility mapping (QSM).Objective: Here, we investigate brain alterations of QSM values in AD and non-AD patients as compared to healthy controls (HC) in the superior temporal sulcus and its banks (BANKSSTS), one of the top AD-affected regions.Methods: Thirty-four patients who underwent brain MRI including a multi-echo gradient-echo sequence were subdivided into AD (n = 19) and non-AD (n = 15) groups according to their clinical profile, CSF (A beta(42/40)) and/or amyloid-PET status. Ten HC were also included. QSM values were extracted from left and right BANKSSTS and compared among groups. Correlation and binomial regression analyses between QSM values and CSF-AD biomarkers were conducted.Results: QSM in left BANKSSTS was significantly different among groups (p = 0.003, H= 11.40), being higher in AD. QSM values in left BANKSSTS were correlated with A beta(42) (rho -0.55, p = 0.005), A beta(42/40) (rho -0.66, p < 0.001), pTau (rho 0.63, p < 0.001), tTau (rho 0.56, p = 0.005), tTau/A beta(42) (rho 0.68, p < 0.001) and pTau/A beta(42) (rho 0.71, p < 0.001). No correlations between QSM values and amyloid-PET SUVR in the left BANKSSTS were found. QSM values in left BANKSSTS showed good accuracy in discriminating AD (AUC= 0.80, CI95% [0.66-0.93]). Higher QSM values were independent predictors of A beta(42) (B = 0.63, p = 0.032), A beta(42/40) (B = 0.81, p = 0.028), pTau (B = 0.96, p = 0.046), tTau (B = 0.55, p = 0.027), and tTau/A beta (42) (B = 1.13, p = 0.042) positivity.Conclusion: Our preliminary data support the potential role of increased QSM values in the left BANKSSTS as an auxiliary imaging biomarker in AD diagnosis.
Alzheimer’s disease; biomarkers; cerebrospinal fluid; iron; magnetic resonance imaging;
Settore BIO/13 - Biologia Applicata
2023
30-mag-2023
Article (author)
File in questo prodotto:
File Dimensione Formato  
Sacchi et al.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 221.35 kB
Formato Adobe PDF
221.35 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/983170
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact