settings Order Article Reprints Open AccessReview Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals by Francesca Gado [ORCID] , Giulio Ferrario [ORCID] , Larissa Della Vedova [ORCID] , Beatrice Zoanni , Alessandra Altomare [ORCID] , Marina Carini , Giancarlo Aldini [ORCID] , Alfonsina D’Amato * [ORCID] and Giovanna Baron [ORCID] Department of Pharmaceutical Sciences (DISFARM), State University of Milan, Via Mangiagalli 25, 20133 Milan, Italy * Author to whom correspondence should be addressed. Molecules 2023, 28(3), 1356; https://doi.org/10.3390/molecules28031356 Received: 31 December 2022 / Revised: 27 January 2023 / Accepted: 28 January 2023 / Published: 31 January 2023 (This article belongs to the Special Issue Recent Advances in Development of Small Molecules to Fight Cancer) Download Browse Figures Versions Notes Abstract Plant secondary metabolites, known as phytochemicals, have recently gained much attention in light of the “circular economy”, to reutilize waste products deriving from agriculture and food industry. Phytochemicals are known for their onco-preventive and chemoprotective effects, among several other beneficial properties. Apple phytochemicals have been extensively studied for their effectiveness in a wide range of diseases, cancer included. This review aims to provide a thorough overview of the main studies reported in the literature concerning apple phytochemicals, mostly polyphenols, in cancer prevention. Although there are many different mechanisms targeted by phytochemicals, the Nrf2 and NF-κB signaling pathways are the ones this review will be focused on, highlighting also the existing crosstalk between these two systems.

Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals / F. Gado, G. Ferrario, L. DELLA VEDOVA, B. Zoanni, A.A. Altomare, M. Carini, G. Aldini, A. D'Amato, G. Baron. - In: MOLECULES. - ISSN 1420-3049. - 28:3(2023 Jan 31), pp. 1356.1-1356.14. [10.3390/molecules28031356]

Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals

F. Gado
Primo
;
G. Ferrario
Secondo
;
L. DELLA VEDOVA;B. Zoanni;A.A. Altomare;M. Carini;G. Aldini;A. D'Amato
Penultimo
;
G. Baron
Ultimo
2023

Abstract

settings Order Article Reprints Open AccessReview Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals by Francesca Gado [ORCID] , Giulio Ferrario [ORCID] , Larissa Della Vedova [ORCID] , Beatrice Zoanni , Alessandra Altomare [ORCID] , Marina Carini , Giancarlo Aldini [ORCID] , Alfonsina D’Amato * [ORCID] and Giovanna Baron [ORCID] Department of Pharmaceutical Sciences (DISFARM), State University of Milan, Via Mangiagalli 25, 20133 Milan, Italy * Author to whom correspondence should be addressed. Molecules 2023, 28(3), 1356; https://doi.org/10.3390/molecules28031356 Received: 31 December 2022 / Revised: 27 January 2023 / Accepted: 28 January 2023 / Published: 31 January 2023 (This article belongs to the Special Issue Recent Advances in Development of Small Molecules to Fight Cancer) Download Browse Figures Versions Notes Abstract Plant secondary metabolites, known as phytochemicals, have recently gained much attention in light of the “circular economy”, to reutilize waste products deriving from agriculture and food industry. Phytochemicals are known for their onco-preventive and chemoprotective effects, among several other beneficial properties. Apple phytochemicals have been extensively studied for their effectiveness in a wide range of diseases, cancer included. This review aims to provide a thorough overview of the main studies reported in the literature concerning apple phytochemicals, mostly polyphenols, in cancer prevention. Although there are many different mechanisms targeted by phytochemicals, the Nrf2 and NF-κB signaling pathways are the ones this review will be focused on, highlighting also the existing crosstalk between these two systems.
phytochemicals; apple polyphenols; Nrf2 signaling pathway; NF-κB signaling pathway; anti-cancer activity; Nrf2/NF-κB crosstalk; secondary metabolites; circular economy;
Settore CHIM/08 - Chimica Farmaceutica
31-gen-2023
Article (author)
File in questo prodotto:
File Dimensione Formato  
molecules-28-01356.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 1.6 MB
Formato Adobe PDF
1.6 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/952998
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 4
social impact