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IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishBackground: Different diets result in significantly different phenotypes through metabolicand genomic reprogramming. Epigenetic marks, identified in humans and mouse models throughcaloric restriction, a high-fat diet or the intake of specific bioactives, suggest that genomic reprogram-ming drives this metabolic reprogramming and mediates the effect of nutrition on health. Histonemodifications encode the epigenetic signal, which adapts genome functions to environmental con-ditions, including diets, by tuning the structure and properties of chromatin. To date, the effect ofdifferent diets on the genome-wide distribution of critical histone marks has not been determined.Methods: Using chromatin immunoprecipitation sequencing, we investigated the distribution of thetrimethylation of lysine 4 of histone H3 in the liver of mice fed for one year with five different diets,including: chow containing yellow corn powder as an extra source of plant bioactives or specificallyenriched with Cyanidin-3-O-Glucoside, high-fat-enriched obesogenic diets, and caloric-restrictedpro-longevity diets. Conclusions: Comparison of the resulting histone mark profiles revealed thatfunctional food containing cyanidin determines a broad effect.
Comparative Analysis of Histone H3K4me3 Distribution in Mouse Liver in Different Diets Reveals the Epigenetic Efficacy of Cyanidin-3-O-glucoside Dietary Intake / G. Persico, F. Casciaro, A. Marinelli, C. Tonelli, K. Petroni, M. Giorgio. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 22:12(2021 Jun 17), pp. 6503.1-6503.10. [10.3390/ijms22126503]
| Titolo: | Comparative Analysis of Histone H3K4me3 Distribution in Mouse Liver in Different Diets Reveals the Epigenetic Efficacy of Cyanidin-3-O-glucoside Dietary Intake | |
| Autori: | ||
| Parole Chiave: | diets; functional food; anthocyanins; epigenetics; histone modifications; mouse liver; | |
| Settore Scientifico Disciplinare: | Settore BIO/18 - Genetica | |
| Data di pubblicazione: | 17-giu-2021 | |
| Rivista: | ||
| Tipologia: | Article (author) | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.3390/ijms22126503 | |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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|---|---|---|---|---|
| ijms-22-06503.pdf | Publisher's version/PDF | Open Access Visualizza/Apri |
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