This study was aimed at demonstrating the substantial equivalence of two extra virgin olive oil samples extracted from the same batch of Coratina olives with (OMU) or without (OMN) using ultrasound technology, by performing chemical, biochemical, and cellular investigations. The volatile organic compounds compositions and phenolic profiles were very similar, showing that, while increasing the extraction yields, the innovative process does not change these features. The antioxidant and hypocholesterolemic activities of the extra virgin olive oil (EVOO) phenol extracts were also preserved, since OMU and OMN had equivalent abilities to scavenge the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radicals in vitro and to protect HepG2 cells from oxidative stress induced by H2O2, reducing intracellular reactive oxygen species (ROS) and lipid peroxidation levels. In addition, by inhibiting 3-hydroxy-3-methylglutarylcoenzyme a reductase, both samples modulated the low-density lipoprotein receptor (LDLR) pathway leading to increased LDLR protein levels and activity.
Virgin Olive Oil Extracts Reduce Oxidative Stress and Modulate Cholesterol Metabolism: Comparison between Oils Obtained with Traditional and Innovative Processes / C. Lammi, N. Mulinacci, L. Cecchi, M. Bellumori, C. Bollati, M. Bartolomei, C. Franchini, M. Lisa Clodoveo, F. Corbo, A. Arnoldi. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 9:9(2020 Aug 27), pp. 798.1-798.17.
|Titolo:||Virgin Olive Oil Extracts Reduce Oxidative Stress and Modulate Cholesterol Metabolism: Comparison between Oils Obtained with Traditional and Innovative Processes|
LAMMI, CARMEN (Primo) (Corresponding)
BOLLATI, CARLOTTA (Secondo)
BARTOLOMEI, MARTINA (Penultimo)
ARNOLDI, ANNA (Ultimo)
|Parole Chiave:||EVOO extract; HepG2 cells; IOC methods; LDLR; PCSK9; antioxidant|
|Settore Scientifico Disciplinare:||Settore CHIM/10 - Chimica degli Alimenti|
|Progetto:||Claims of olive oil to improve the market value of the product|
|Data di pubblicazione:||27-ago-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/antiox9090798|
|Appare nelle tipologie:||01 - Articolo su periodico|