Binary fission is the most common mode of bacterial cell division and is mediated by a multiprotein complex denominated the divisome. The constriction of the Z-ring splits the mother bacterial cell into two daughter cells of the same size. The Z-ring is formed by the polymerization of FtsZ, a bacterial protein homologue of eukaryotic tubulin, and it represents the first step of bacterial cytokinesis. The high grade of conservation of FtsZ in most prokaryotic organisms and its relevance in orchestrating the whole division system make this protein a fascinating target in antibiotic research. Indeed, FtsZ inhibition results in the complete blockage of the division system and, consequently, in a bacteriostatic or a bactericidal effect. Since many papers and reviews already discussed the physiology of FtsZ and its auxiliary proteins, as well as the molecular mechanisms in which they are involved, here, we focus on the discussion of the most compelling FtsZ inhibitors, classified by their main protein binding sites and following a medicinal chemistry approach.

Targeting bacterial cell division: A binding site-centered approach to the most promising inhibitors of the essential protein FtsZ / A. Casiraghi, L. Suigo, E. Valoti, V. Straniero. - In: ANTIBIOTICS. - ISSN 2079-6382. - 9:2(2020 Feb 07), p. 69.69. [10.3390/antibiotics9020069]

Targeting bacterial cell division: A binding site-centered approach to the most promising inhibitors of the essential protein FtsZ

Casiraghi A.;Suigo L.;Valoti E.;Straniero V.
2020-02-07

Abstract

Binary fission is the most common mode of bacterial cell division and is mediated by a multiprotein complex denominated the divisome. The constriction of the Z-ring splits the mother bacterial cell into two daughter cells of the same size. The Z-ring is formed by the polymerization of FtsZ, a bacterial protein homologue of eukaryotic tubulin, and it represents the first step of bacterial cytokinesis. The high grade of conservation of FtsZ in most prokaryotic organisms and its relevance in orchestrating the whole division system make this protein a fascinating target in antibiotic research. Indeed, FtsZ inhibition results in the complete blockage of the division system and, consequently, in a bacteriostatic or a bactericidal effect. Since many papers and reviews already discussed the physiology of FtsZ and its auxiliary proteins, as well as the molecular mechanisms in which they are involved, here, we focus on the discussion of the most compelling FtsZ inhibitors, classified by their main protein binding sites and following a medicinal chemistry approach.
Bacterial cell division process; FtsZ inhibitors; GTP-binding site; Interdomain site
Settore CHIM/08 - Chimica Farmaceutica
https://www.mdpi.com/2079-6382/9/2/69/pdf
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/717525
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