Abstract: Background: Superficial fungal infections are the most common fungal diseases in humans, affecting more than 25% of the population worldwide.Methods: In the present study, we have investigated the activity of kakuol, a natural compound isolated from the rhizomes of Asarum sieboldii, and some analogues, against various dermatophytes and pharmacologically relevant yeasts. Results: One of the tested compounds, 2-acryloyl-4,5-methylenedioxyphenol, showed a broadspectrum activity against most of the fungal species assayed, resulting particularly effective against dermatophyte strains (MIC values in the range of 0.25-0.5 μg/mL, two/four-fold lower than the positive control miconazole). Conclusion: The results suggest that this molecule can be considered a promising starting point for the development of new antifungal compounds.

2-Acryloyl-4,5-methylenedioxyphenol : A small molecule endowed with antidermatophytic activity / M. Zuccolo, S. Dallavalle, R. Cincinelli, L. Mattio, S. Mazzini, M. De Cesare, L. Musso. - In: LETTERS IN DRUG DESIGN & DISCOVERY. - ISSN 1570-1808. - 16:4(2019 May), pp. 461-466. [10.2174/1570180815666180803115347]

2-Acryloyl-4,5-methylenedioxyphenol : A small molecule endowed with antidermatophytic activity

M. Zuccolo;S. Dallavalle
;
R. Cincinelli;L. Mattio;S. Mazzini;L. Musso
2019

Abstract

Abstract: Background: Superficial fungal infections are the most common fungal diseases in humans, affecting more than 25% of the population worldwide.Methods: In the present study, we have investigated the activity of kakuol, a natural compound isolated from the rhizomes of Asarum sieboldii, and some analogues, against various dermatophytes and pharmacologically relevant yeasts. Results: One of the tested compounds, 2-acryloyl-4,5-methylenedioxyphenol, showed a broadspectrum activity against most of the fungal species assayed, resulting particularly effective against dermatophyte strains (MIC values in the range of 0.25-0.5 μg/mL, two/four-fold lower than the positive control miconazole). Conclusion: The results suggest that this molecule can be considered a promising starting point for the development of new antifungal compounds.
Kakuol; Asarum sieboldii; antifungal agents; Candida albicans; dermatophytes; 3,4-methylenedioxyphenol
Settore CHIM/06 - Chimica Organica
Settore CHIM/08 - Chimica Farmaceutica
Article (author)
File in questo prodotto:
File Dimensione Formato  
2019KAKUOLO 2148-MS-2.pdf

Open Access dal 01/06/2020

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 839.04 kB
Formato Adobe PDF
839.04 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/599712
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact