Abstract: Background: Superficial fungal infections are the most common fungal diseases in humans, affecting more than 25% of the population worldwide.Methods: In the present study, we have investigated the activity of kakuol, a natural compound isolated from the rhizomes of Asarum sieboldii, and some analogues, against various dermatophytes and pharmacologically relevant yeasts. Results: One of the tested compounds, 2-acryloyl-4,5-methylenedioxyphenol, showed a broadspectrum activity against most of the fungal species assayed, resulting particularly effective against dermatophyte strains (MIC values in the range of 0.25-0.5 μg/mL, two/four-fold lower than the positive control miconazole). Conclusion: The results suggest that this molecule can be considered a promising starting point for the development of new antifungal compounds.
2-Acryloyl-4,5-methylenedioxyphenol : A small molecule endowed with antidermatophytic activity / M. Zuccolo, S. Dallavalle, R. Cincinelli, L. Mattio, S. Mazzini, M. De Cesare, L. Musso. - In: LETTERS IN DRUG DESIGN & DISCOVERY. - ISSN 1570-1808. - 16:4(2019 May), pp. 461-466. [10.2174/1570180815666180803115347]
2-Acryloyl-4,5-methylenedioxyphenol : A small molecule endowed with antidermatophytic activity
M. Zuccolo;S. Dallavalle
;R. Cincinelli;L. Mattio;S. Mazzini;L. Musso
2019
Abstract
Abstract: Background: Superficial fungal infections are the most common fungal diseases in humans, affecting more than 25% of the population worldwide.Methods: In the present study, we have investigated the activity of kakuol, a natural compound isolated from the rhizomes of Asarum sieboldii, and some analogues, against various dermatophytes and pharmacologically relevant yeasts. Results: One of the tested compounds, 2-acryloyl-4,5-methylenedioxyphenol, showed a broadspectrum activity against most of the fungal species assayed, resulting particularly effective against dermatophyte strains (MIC values in the range of 0.25-0.5 μg/mL, two/four-fold lower than the positive control miconazole). Conclusion: The results suggest that this molecule can be considered a promising starting point for the development of new antifungal compounds.File | Dimensione | Formato | |
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