Abstract: Background: Superficial fungal infections are the most common fungal diseases in humans, affecting more than 25% of the population worldwide.Methods: In the present study, we have investigated the activity of kakuol, a natural compound isolated from the rhizomes of Asarum sieboldii, and some analogues, against various dermatophytes and pharmacologically relevant yeasts. Results: One of the tested compounds, 2-acryloyl-4,5-methylenedioxyphenol, showed a broadspectrum activity against most of the fungal species assayed, resulting particularly effective against dermatophyte strains (MIC values in the range of 0.25-0.5 μg/mL, two/four-fold lower than the positive control miconazole). Conclusion: The results suggest that this molecule can be considered a promising starting point for the development of new antifungal compounds.
2-Acryloyl-4,5-methylenedioxyphenol : A small molecule endowed with antidermatophytic activity / M. Zuccolo, S. Dallavalle, R. Cincinelli, L. Mattio, S. Mazzini, M. De Cesare, L. Musso. - In: LETTERS IN DRUG DESIGN & DISCOVERY. - ISSN 1570-1808. - 16:4(2019 May), pp. 461-466.
Titolo: | 2-Acryloyl-4,5-methylenedioxyphenol : A small molecule endowed with antidermatophytic activity |
Autori: | |
Parole Chiave: | Kakuol; Asarum sieboldii; antifungal agents; Candida albicans; dermatophytes; 3,4-methylenedioxyphenol |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica Settore CHIM/08 - Chimica Farmaceutica |
Data di pubblicazione: | mag-2019 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.2174/1570180815666180803115347 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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File | Descrizione | Tipologia | Licenza | |
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2019KAKUOLO 2148-MS-2.pdf | Post-print, accepted manuscript ecc. (versione accettata dall'editore) | Open Access Visualizza/Apri |