Poly(g-glutamic acid) is a linear anionic biopolymer synthesized by bacterial fermentation from sustainable resources. Being water soluble, biodegradable, edible and non-toxic to humans and the environment, applications of gamma-PGA are of interest in a broad range of industrial sectors. However, preparation of gamma-PGA derivatives is plagued by several difficulties including its scarce solubility in organic solvents. We here report a gamma-PGA derivatization procedure based on the use of its tetrabutylammonium salt. The modified solubility of gamma-PGA provided by counterion exchange led to the synthesis of poly(alpha-ethyl-gamma-glutamate), poly(alpha-benzyl-gamma-glutamate) and poly(alpha-n-butyl-gamma-glutamate) under smoother conditions and an almost complete functionalization degree.
Esterification of poly(γ-glutamic acid) (γ-PGA) mediated by its tetrabutylammonium salt / M. Biagiotti, G. Borghese, P. Francescato, C. Morelli, A..M. Albertini, T. Bavaro, D. Ubiali, R. Mendichi, G. Speranza. - In: RSC ADVANCES. - ISSN 2046-2069. - 6:50(2016), pp. 43954-43958.
|Titolo:||Esterification of poly(γ-glutamic acid) (γ-PGA) mediated by its tetrabutylammonium salt|
BIAGIOTTI, MARCO (Primo)
BORGHESE, GIOVANNI (Secondo)
SPERANZA, GIOVANNA (Corresponding)
|Parole Chiave:||poly(alpha-alkyl gamma-glutamate)s; microbial origin; glutamic acid; esters; microorganism; convenient|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
Settore CHIM/08 - Chimica Farmaceutica
|Data di pubblicazione:||2016|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1039/C6RA08567A|
|Appare nelle tipologie:||01 - Articolo su periodico|