The present study aimed to investigate the inter- and intraday repeatability of reactive hyperemia index (RHI) measured by Endo-PAT in healthy volunteers. Interday RHI repeatability was tested in two consecutive days in a group of thirty-one male subjects. Intraday repeatability was investigated at baseline and after 2 and 4 h in a group of sixteen volunteers. Data were evaluated by analysis of variance. Bland-Altman plot, coefficient of variation (CV), coefficient of repeatability (CR) and intraclass correlation coefficient (ICC) were measured. While interday RHI repeatability was found to be reliable (CV: 6.0%; CR: 0.51; ICC: 0.77), multiple evaluations within the same day significantly (p<0.001) affected RHI (repeatability of the measurement - CV: 18.8%; CR: 1.26; ICC: 0.48). In particular, a significant increase in RHI occurred at 4 h compared to 2 h (+16.8%; p<0.05) and to baseline (+30.1%; p<0.05). In conclusion, RHI showed good interday but poor intraday repeatability. Multiple evaluations increased RHI especially in subjects with endothelial dysfunction who improved or reversed their impairment. These results show the potential limitations of multiple Endo-PAT measurements within the same day and the importance of standardizing the protocols before RHI evaluations.

Intra and inter-day repeatability of peripheral arterial function: suitability and potential limitations / C. Del Bo', V. Deon, M. Porrini, J. Campolo, M. Parolini, P. Riso. - In: MICROCIRCULATION. - ISSN 1549-8719. - 23:7(2016 Oct), pp. 503-511. [10.1111/micc.12300]

Intra and inter-day repeatability of peripheral arterial function: suitability and potential limitations

C. Del Bo';V. Deon;M. Porrini;P. Riso
2016

Abstract

The present study aimed to investigate the inter- and intraday repeatability of reactive hyperemia index (RHI) measured by Endo-PAT in healthy volunteers. Interday RHI repeatability was tested in two consecutive days in a group of thirty-one male subjects. Intraday repeatability was investigated at baseline and after 2 and 4 h in a group of sixteen volunteers. Data were evaluated by analysis of variance. Bland-Altman plot, coefficient of variation (CV), coefficient of repeatability (CR) and intraclass correlation coefficient (ICC) were measured. While interday RHI repeatability was found to be reliable (CV: 6.0%; CR: 0.51; ICC: 0.77), multiple evaluations within the same day significantly (p<0.001) affected RHI (repeatability of the measurement - CV: 18.8%; CR: 1.26; ICC: 0.48). In particular, a significant increase in RHI occurred at 4 h compared to 2 h (+16.8%; p<0.05) and to baseline (+30.1%; p<0.05). In conclusion, RHI showed good interday but poor intraday repeatability. Multiple evaluations increased RHI especially in subjects with endothelial dysfunction who improved or reversed their impairment. These results show the potential limitations of multiple Endo-PAT measurements within the same day and the importance of standardizing the protocols before RHI evaluations.
augmentation index; healthy young male; peripheral arterial tonometry; reactive hyperemia index; repeatability
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
ott-2016
Article (author)
File in questo prodotto:
File Dimensione Formato  
Del Bo' et al Microcirculation.pdf

accesso aperto

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 452.79 kB
Formato Adobe PDF
452.79 kB Adobe PDF Visualizza/Apri
Del Bo-_et_al-2016-Microcirculation.pdf

accesso riservato

Descrizione: Articolo Principale
Tipologia: Publisher's version/PDF
Dimensione 421.53 kB
Formato Adobe PDF
421.53 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/430432
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact