Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.

Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease / E. Ferri, B. Arosio, C. D'Addario, D. Galimberti, C. Gussago, M. Pucci, M. Casati, C. Fenoglio, C. Abbate, P.D. Rossi, E. Scarpini, M. Maccarrone, D. Mari. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - 362(2016 Mar 15), pp. 283-286.

Gene promoter methylation and expression of Pin1 differ between patients with frontotemporal dementia and Alzheimer's disease

E. Ferri
Primo
;
B. Arosio
Secondo
;
D. Galimberti;C. Gussago;M. Casati;C. Fenoglio;C. Abbate;E. Scarpini;D. Mari
Ultimo
2016-03-15

Abstract

Frontotemporal Dementia (FTD) and Alzheimer's Disease (AD) share the accumulation of fibrillar aggregates of misfolded proteins. To better understand these neurodegenerative diseases and identify biomarkers in easily accessible cells, we investigated DNA methylation at Pin1 gene promoter and its expression in peripheral blood mononuclear cells of FTD patients. We found a lower gene expression of Pin1 with a higher DNA methylation in three CpG sites at Pin1 gene promoter analysed in FTD subjects, in contrast to a higher gene expression with a lower methylation in AD subjects and controls. These data suggest an important and distinct involvement of Pin1 in these two types of dementia.
Alzheimer's disease; Frontotemporal dementia; Methylation; Neurodegeneration; Peripheral marker; Pin1
Settore MED/09 - Medicina Interna
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/376193
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