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The purpose of this study was to evaluate the effect of supplementation with procyanidins from Vitis vinifera on markers of oxidative stress. Ten healthy volunteers received a daily dose of 110 mg of procyanidins for 30 days. Fasting venous blood samples were taken before and at the end of the supplementation period and after 7 days of wash-out. The total antioxidant activity and the plasma concentrations of R-tocopherol were not modified. Conversely, the levels of R-tocopherol in red blood cell membranes increased significantly from 1.8 ( 0.1 to 2.8 ( 0.2 mg/g. Similarly, the lymphocyte oxidized DNA [8-oxo-7,8-dihydro-2¢-deoxyguanosine/2¢-deoxyguanosine ratio] was reduced from 7.23 ( 2.47 to 2.34 (0.51, and the red blood cell membrane fatty acid composition shifted to a higher level of polyunsaturated fatty acids. On the basis of these results, it may be suggested that dietary procyanidins exert their antioxidant protection in vivo by sparing liposoluble vitamin E and reducing DNA oxidative damage.

Procyanidins from Vitis vinifera seeds : in vivo effects on oxidative stress / P. Simonetti, S. Ciappellano, C. Gardana, L. Bramati, P. Pietta. - In: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. - ISSN 0021-8561. - 50:21(2002 Oct 09), pp. 6217-6221.

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