Different types of cancer take advantage of inflammatory components to improve their life-span in the organs. A sustenance of growth factors and cytokines (e. g. interleukin (IL)-1, tumor necrosis factor, IL-6, vascular endothelial growth factor) supports malignant cell progression and contributes to suppress the body immune defense. Strategies to modulate the host micro-environment offer new approaches for anti-cancer therapies. For these reasons new molecules with anti-tumor and anti-inflammatory features (e. g. trabectedin) are looked at with new eyes in the light of the crucial link between inflammation and cancer.
Targeting of the innate immunity/inflammation as complementary anti-tumor therapies / G. Germano, A. Mantovani, P. Allavena. - In: ANNALS OF MEDICINE. - ISSN 0785-3890. - 43:8(2011 Dec), pp. 581-593.
Targeting of the innate immunity/inflammation as complementary anti-tumor therapies
A. MantovaniSecondo
;
2011
Abstract
Different types of cancer take advantage of inflammatory components to improve their life-span in the organs. A sustenance of growth factors and cytokines (e. g. interleukin (IL)-1, tumor necrosis factor, IL-6, vascular endothelial growth factor) supports malignant cell progression and contributes to suppress the body immune defense. Strategies to modulate the host micro-environment offer new approaches for anti-cancer therapies. For these reasons new molecules with anti-tumor and anti-inflammatory features (e. g. trabectedin) are looked at with new eyes in the light of the crucial link between inflammation and cancer.
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