Chemokines are key players of the cancer-related inflammation. Chemokine ligands and receptors are downstream of genetic events that cause neoplastic transformation and are abundantly expressed in chronic inflammatory conditions which predispose to cancer. Components of the chemokine system affect multiple pathways of tumor progression including: leukocyte recruitment, neo-angiogenesis, tumor cell proliferation and survival, invasion and metastasis. Evidence in pre-clinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.
Chemokines in cancer related inflammation / P. Allavena, G. Germano, F. Marchesi, A. Mantovani. - In: EXPERIMENTAL CELL RESEARCH. - ISSN 0014-4827. - 317:5(2011 Mar 10), pp. 664-673. [10.1016/j.yexcr.2010.11.013]
Chemokines in cancer related inflammation
G. Germano;F. MarchesiPenultimo
;A. MantovaniUltimo
2011
Abstract
Chemokines are key players of the cancer-related inflammation. Chemokine ligands and receptors are downstream of genetic events that cause neoplastic transformation and are abundantly expressed in chronic inflammatory conditions which predispose to cancer. Components of the chemokine system affect multiple pathways of tumor progression including: leukocyte recruitment, neo-angiogenesis, tumor cell proliferation and survival, invasion and metastasis. Evidence in pre-clinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.
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