Towards the Construction of an RNA-based Knowledge Graph

The use of RNA molecules for developing new drugs and new vaccines is attracting more and more scientific centers all over the world that produce biological banks with different kinds of relationships existing among the different coding and non-coding molecules. Collecting and identifying relationships among the data included in these collections is of paramount importance for knowledge discovery and analysis. In this paper, we describe the initial steps in the construction of RNA-KG, an RNA-centered Knowledge Graph that will contain the different types of entities that can be extracted from different public databases and the relationships that can be inferred. A meta-graph reporting the main kinds of relationships that can be included by the integration of the identified data sources is finally presented. These activities are conducted in the context of the “National Center for Gene Therapy and Drugs based on RNA Technology” funded by the Italian PNRR and the NextGenerationEU program.