Early-onset parkinsonism (EO parkinsonism), defined as subjects with disease onset before the age of 40 or 50 years, can be the main clinical presentation of a variety of conditions that are important to differentiate. Although rarer than classical late-onset Parkinson's disease (PD) and not infrequently overlapping with forms of juvenile onset PD, a correct diagnosis of the specific cause of EO parkinsonism is critical for offering appropriate counseling to patients, for family and work planning, and to select the most appropriate symptomatic or etiopathogenic treatments. Clinical features, radiological and laboratory findings are crucial for guiding the differential diagnosis. Here we summarize the most important conditions associated with primary and secondary EO parkinsonism. We also proposed a practical approach based on the current literature and expert opinion to help movement disorders specialists and neurologists navigate this complex and challenging landscape.

A Practical Approach to Early-Onset Parkinsonism / G.M. Riboldi, E. Frattini, E. Monfrini, S.J. Frucht, A. Di Fonzo. - In: JOURNAL OF PARKINSON'S DISEASE. - ISSN 1877-7171. - 12:1(2022 Jan 21), pp. 1-26. [10.3233/JPD-212815]

A Practical Approach to Early-Onset Parkinsonism

E. Frattini
Secondo
;
E. Monfrini;
2022

Abstract

Early-onset parkinsonism (EO parkinsonism), defined as subjects with disease onset before the age of 40 or 50 years, can be the main clinical presentation of a variety of conditions that are important to differentiate. Although rarer than classical late-onset Parkinson's disease (PD) and not infrequently overlapping with forms of juvenile onset PD, a correct diagnosis of the specific cause of EO parkinsonism is critical for offering appropriate counseling to patients, for family and work planning, and to select the most appropriate symptomatic or etiopathogenic treatments. Clinical features, radiological and laboratory findings are crucial for guiding the differential diagnosis. Here we summarize the most important conditions associated with primary and secondary EO parkinsonism. We also proposed a practical approach based on the current literature and expert opinion to help movement disorders specialists and neurologists navigate this complex and challenging landscape.
Parkinsonian disorders; Parkinson’s disease; adult-onset dystonia-parkinsonism; autosomal recessive early-onset; dopa-responsive dystonia; genetic counseling; secondary Parkinson’s disease;
Settore MED/26 - Neurologia
21-gen-2022
2021
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/957986
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