Purpose Positron emission tomography (PET) with amyloid tracers (amy-PET) allows the quantification of pathological amyloid deposition in the brain tissues, including the white matter (WM). Here, we evaluate amy-PET uptake in WM lesions (WML) and in the normal-appearing WM (NAWM) of patients with Alzheimer's disease (AD) and non-AD type of dementia. Methods Thirty-three cognitively impaired subjects underwent brain magnetic resonance imaging (MRI), A beta(1-42) (A beta) determination in the cerebrospinal fluid (CSF) and amy-PET. Twenty-three patients exhibiting concordant results in both CSF analysis and amy-PET for cortical amyloid deposition were recruited and divided into two groups, amyloid positive (A+) and negative (A-). WML quantification and brain volumes' segmentation were performed. Standardized uptake values ratios (SUVR) were calculated in the grey matter (GM), NAWM and WML on amy-PET coregistered to MRI images. Results A+ compared to A- showed a higher WML load (p = 0.049) alongside higher SUVR in all brain tissues (p < 0.01). No correlations between CSF A beta levels and WML and NAWM SUVR were found in A+, while, in A-, CSF A beta levels were directly correlated to NAWM SUVR (p = 0.04). CSF A beta concentration was the only predictor of NAWM SUVR (adj R-2 = 0.91; p = 0.04) in A-. In A+ but not in A- direct correlations were identified between WM and GM SUVR (p < 0.01). Conclusions Our data provide evidence on the role of amy-PET in the assessment of microstructural WM injury in non-AD dementia, whereas amy-PET seems less suitable to assess WM damage in AD patients due to a plausible amyloid accrual therein.

Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage / A.M. Pietroboni, A. Colombi, T. Carandini, L. Sacchi, C. Fenoglio, G. Marotta, A. Arighi, M.A. De Riz, G.G. Fumagalli, M. Castellani, M. Bozzali, E. Scarpini, D. Galimberti. - In: ALZHEIMER'S RESEARCH & THERAPY. - ISSN 1758-9193. - 14:1(2022), pp. 33.1-33.8. [10.1186/s13195-021-00933-1]

Amyloid PET imaging and dementias: potential applications in detecting and quantifying early white matter damage

L. Sacchi;C. Fenoglio;E. Scarpini
Penultimo
;
D. Galimberti
Ultimo
2022

Abstract

Purpose Positron emission tomography (PET) with amyloid tracers (amy-PET) allows the quantification of pathological amyloid deposition in the brain tissues, including the white matter (WM). Here, we evaluate amy-PET uptake in WM lesions (WML) and in the normal-appearing WM (NAWM) of patients with Alzheimer's disease (AD) and non-AD type of dementia. Methods Thirty-three cognitively impaired subjects underwent brain magnetic resonance imaging (MRI), A beta(1-42) (A beta) determination in the cerebrospinal fluid (CSF) and amy-PET. Twenty-three patients exhibiting concordant results in both CSF analysis and amy-PET for cortical amyloid deposition were recruited and divided into two groups, amyloid positive (A+) and negative (A-). WML quantification and brain volumes' segmentation were performed. Standardized uptake values ratios (SUVR) were calculated in the grey matter (GM), NAWM and WML on amy-PET coregistered to MRI images. Results A+ compared to A- showed a higher WML load (p = 0.049) alongside higher SUVR in all brain tissues (p < 0.01). No correlations between CSF A beta levels and WML and NAWM SUVR were found in A+, while, in A-, CSF A beta levels were directly correlated to NAWM SUVR (p = 0.04). CSF A beta concentration was the only predictor of NAWM SUVR (adj R-2 = 0.91; p = 0.04) in A-. In A+ but not in A- direct correlations were identified between WM and GM SUVR (p < 0.01). Conclusions Our data provide evidence on the role of amy-PET in the assessment of microstructural WM injury in non-AD dementia, whereas amy-PET seems less suitable to assess WM damage in AD patients due to a plausible amyloid accrual therein.
Alzheimer’s disease; Amyloid; Non-AD dementias; White matter; amy-PET; Amyloid; Amyloid beta-Peptides; Humans; Magnetic Resonance Imaging; Positron-Emission Tomography; Alzheimer Disease; White Matter
Settore BIO/13 - Biologia Applicata
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/943384
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