A collection of nature-inspired lipophilic phenolic esters have been prepared by an enzymatic synthesis under flow conditions, using the immobilized lipase B from Candida antarctica (Novozyme 435 (R)) as a catalyst in cyclopentyl methyl ether (CPME), a non-conventional and green solvent. Their antimicrobial activity against four selected bacterial strains together with their efficiency as radical scavengers were evaluated. The obtained compounds were characterized by enhanced lipophilicity in comparison with the parent non-esterified compounds, which increased the possibility of their use as additives in the food industry.

Enzymatic continuous-flow preparation of nature-inspired phenolic esters as antiradical and antimicrobial noagents / F. Annunziata, M.L. Contente, V. Anzi, S. Donzella, P. Conti, F. Molinari, P.A. Martino, G. Meroni, V.M. Sora, L. Tamborini, A. Pinto. - In: FOOD CHEMISTRY. - ISSN 0308-8146. - 390:(2022 Oct 01), pp. 133195.1-133195.6. [10.1016/j.foodchem.2022.133195]

Enzymatic continuous-flow preparation of nature-inspired phenolic esters as antiradical and antimicrobial noagents

F. Annunziata
Primo
;
M.L. Contente
Secondo
;
V. Anzi;S. Donzella;P. Conti;F. Molinari;P.A. Martino;G. Meroni;V.M. Sora;L. Tamborini
Penultimo
;
A. Pinto
Ultimo
2022-10-01

Abstract

A collection of nature-inspired lipophilic phenolic esters have been prepared by an enzymatic synthesis under flow conditions, using the immobilized lipase B from Candida antarctica (Novozyme 435 (R)) as a catalyst in cyclopentyl methyl ether (CPME), a non-conventional and green solvent. Their antimicrobial activity against four selected bacterial strains together with their efficiency as radical scavengers were evaluated. The obtained compounds were characterized by enhanced lipophilicity in comparison with the parent non-esterified compounds, which increased the possibility of their use as additives in the food industry.
Antimicrobial agents; Flow chemistry; Food preservatives; Lipase; Phenolic esters; Radical scavenger; Antioxidants; Enzymes, Immobilized; Fungal Proteins; Lipase; Phenols; Anti-Infective Agents; Esters
Settore CHIM/08 - Chimica Farmaceutica
Settore CHIM/10 - Chimica degli Alimenti
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/937212
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