(-)-Cannabidiol (CBD) is a non-psychoactive compound that has already found many medical applications, from the treatment of epilepsy to other neurological disorders. (-)-CBD is usually extracted from Cannabis Sativa, but unfortunately, its isolation among many other structurally related cannabinoids can be challenging. This, along with the increased demand for (-)-CBD, prompted chemists to come up with synthetic strategies that could afford this cannabinoid in good yield and high enantiopurity. Herein, we aim to review the fundamental strategies employed in the stereoselective synthesis of (-)-cannabidiol, spanning from classic approaches to automated ones, highlighting the challenges encountered in the total synthesis of this cannabinoid.

Stereoselective Synthetic Strategies to (-)-Cannabidiol / A. Maiocchi, J. Barbieri, V. Fasano, D. Passarella. - In: CHEMISTRYSELECT. - ISSN 2365-6549. - 7:28(2022 Jul), pp. e202202400.1-e202202400.8. [10.1002/slct.202202400]

Stereoselective Synthetic Strategies to (-)-Cannabidiol

A. Maiocchi
Primo
;
D. Passarella
2022

Abstract

(-)-Cannabidiol (CBD) is a non-psychoactive compound that has already found many medical applications, from the treatment of epilepsy to other neurological disorders. (-)-CBD is usually extracted from Cannabis Sativa, but unfortunately, its isolation among many other structurally related cannabinoids can be challenging. This, along with the increased demand for (-)-CBD, prompted chemists to come up with synthetic strategies that could afford this cannabinoid in good yield and high enantiopurity. Herein, we aim to review the fundamental strategies employed in the stereoselective synthesis of (-)-cannabidiol, spanning from classic approaches to automated ones, highlighting the challenges encountered in the total synthesis of this cannabinoid.
Cannabidiol; Natural products; Stereoselectivity; Total Synthesis; trans-geometry
Settore CHIM/06 - Chimica Organica
12-lug-2022
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/935215
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