The present invention relates to nanoparticles for the delivery of active ingredients across the blood-brain barrier, wherein said nanoparticles comprise at least one ligand at least one linear or branched fatty acid, optionally substituited and/or esterified, satured or unsatured, with a number of carbon atoms between 4 and 22 and said colloidal system comprimes or consists of at least one constituent and, optionally, one or more active ingredients, characterized in that said ligand is bound by a chemical bond to at least one functional group which is present on one or more of the consituents of said colloidal system, so as to form a constituent-ligand conjugate.
Nanoparticles for transport across the blood-brain barrier / E. Cattaneo, M. Valenza, G. Birolini, G. Tosi, B. Ruozi, F. Forni, P. Linciano, M.A. Vandelli.
Nanoparticles for transport across the blood-brain barrier
E. Cattaneo;M. Valenza;G. Birolini;
2022
Abstract
The present invention relates to nanoparticles for the delivery of active ingredients across the blood-brain barrier, wherein said nanoparticles comprise at least one ligand at least one linear or branched fatty acid, optionally substituited and/or esterified, satured or unsatured, with a number of carbon atoms between 4 and 22 and said colloidal system comprimes or consists of at least one constituent and, optionally, one or more active ingredients, characterized in that said ligand is bound by a chemical bond to at least one functional group which is present on one or more of the consituents of said colloidal system, so as to form a constituent-ligand conjugate.
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