: Ginger is among the traditional medicinal plants most diffused and widely consumed around the world. Its beneficial effects, which comprise e.g. anticancer and antiinflammatory activities as well as gastrointestinal regulatory effects, are generally addressed to a family of non-volatile compounds characterized by an arylalkyl long-chained alcohol, diol or ketone moiety. In this work, ginger active principles have been successfully recovered from industrial waste biomasses of fermented ginger. Moreover, their recovery has been combined with the first systematic study of the stereoselective reduction of gingerol-like compounds by isolated alcohol dehydrogenases (ADHs), obtaining the enantioenriched sec -alcohol derivatives via a sustainable biocatalytic path in up to >99% conversions and >99% enantiomeric/diastereomeric excesses.

Stereoselective Biocatalyzed Reductions of Ginger Active Components Recovered from Industrial Wastes / R. Nasti, I. Bassanini, E. Elisa Ferrandi, F. Linguardo, S. Bertuletti, M. Vanoni, S. Riva, L. Verotta, D. Monti. - In: CHEMBIOCHEM. - ISSN 1439-4227. - (2022), pp. e202200105.1-e202200105.11. [Epub ahead of print] [10.1002/cbic.202200105]

Stereoselective Biocatalyzed Reductions of Ginger Active Components Recovered from Industrial Wastes

Rita Nasti;Ivan Bassanini;Susanna Bertuletti;Luisella Verotta;
2022

Abstract

: Ginger is among the traditional medicinal plants most diffused and widely consumed around the world. Its beneficial effects, which comprise e.g. anticancer and antiinflammatory activities as well as gastrointestinal regulatory effects, are generally addressed to a family of non-volatile compounds characterized by an arylalkyl long-chained alcohol, diol or ketone moiety. In this work, ginger active principles have been successfully recovered from industrial waste biomasses of fermented ginger. Moreover, their recovery has been combined with the first systematic study of the stereoselective reduction of gingerol-like compounds by isolated alcohol dehydrogenases (ADHs), obtaining the enantioenriched sec -alcohol derivatives via a sustainable biocatalytic path in up to >99% conversions and >99% enantiomeric/diastereomeric excesses.
biocatalysis; challenging ketones; ginger active principles; stereoselectivity; waste valorization
Settore CHIM/06 - Chimica Organica
Settore CHIM/08 - Chimica Farmaceutica
21-feb-2022
CHEMBIOCHEM
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cbic.202200105
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/914307
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