Bone metastasis is a serious and often lethal complication of particularly frequent carcinomas, such as breast and prostate cancers, which not only reduces survival but also worsens the patients’ quality of life. Therefore, it is important to find new and/or additional therapeutic possibilities that can counteract the colonization of bone tissue. High adherence to the Mediterranean diet (MD) is effective in the prevention of cancer and improves cancer patients’ health, thus, here, we considered its impact on bone metastasis. We highlighted some molecular events relevant for the development of a metastatic phenotype in cancer cells and the alterations of physiological bone remodeling, which occur during skeleton colonization. We then considered those natural compounds present in MD foods with a recognized role to inhibit or reverse the metastatic process both in in vivo and in vitro systems, and we reported the identified mechanisms of action. The knowledge of this bioactivity by the dietary components of the MD, together with its wide access to all people, could help not only to maintain healthy status but also to improve the quality of life of patients with bone metastases.

Mediterranean diet food components as possible adjuvant therapies to counteract breast and prostate cancer progression to bone metastasis / P. Maroni, P. Bendinelli, A. Fulgenzi, A. Ferraretto. - In: BIOMOLECULES. - ISSN 2218-273X. - 11:9(2021 Sep 09), pp. 1336.1-1336.18. [10.3390/biom11091336]

Mediterranean diet food components as possible adjuvant therapies to counteract breast and prostate cancer progression to bone metastasis

Maroni P.;Bendinelli P.;Fulgenzi A.;Ferraretto A.
2021-09-09

Abstract

Bone metastasis is a serious and often lethal complication of particularly frequent carcinomas, such as breast and prostate cancers, which not only reduces survival but also worsens the patients’ quality of life. Therefore, it is important to find new and/or additional therapeutic possibilities that can counteract the colonization of bone tissue. High adherence to the Mediterranean diet (MD) is effective in the prevention of cancer and improves cancer patients’ health, thus, here, we considered its impact on bone metastasis. We highlighted some molecular events relevant for the development of a metastatic phenotype in cancer cells and the alterations of physiological bone remodeling, which occur during skeleton colonization. We then considered those natural compounds present in MD foods with a recognized role to inhibit or reverse the metastatic process both in in vivo and in vitro systems, and we reported the identified mechanisms of action. The knowledge of this bioactivity by the dietary components of the MD, together with its wide access to all people, could help not only to maintain healthy status but also to improve the quality of life of patients with bone metastases.
bone metastasis; breast cancer; epithelial–mesenchymal transition; Mediterranean diet; nutrients; osteoblastic bone metastasis; osteolytic bone metastasis; prostate cancer; bone neoplasms; breast neoplasms; female; humans; male; prostatic neoplasms; chemotherapy, adjuvant; diet, Mediterranean; disease progression; food
Settore MED/04 - Patologia Generale
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
BIOMOLECULES
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/898484
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