Increasing efforts have been focused on development of novel therapeutic approaches based on a carrier mixed with polymeric microparticles (MPs) for promoting bioactive factors delivery. Polymers as poly (lactide-co-glycolide) are the most widely used due to their tunable physico-chemical properties and biomimetic character. Here, PLGA-MPs of different surface charges were dispersed in hyaluronic acid and their impact on the viability of four cell lines was studied. Our data reveal that the most evident effect is the influence of the cell line proliferation-rate on PLGA-MPs stability and aggregation, highlighting the crucial role of the biological context in affecting microparticles clustering and toxicity.

Effects of cell line proliferation on the aggregation and stability of a hyaluronic acid solution (HA)/PLGA microparticles dispersed in the culture system / S. Locarno, A. Galli, S. Argentiere, M. Galgano, I. Giuntini, C. Lenardi, C. Perego. - In: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS. - ISSN 0091-4037. - (2022), pp. 1-9. [Epub ahead of print] [10.1080/00914037.2021.1941953]

Effects of cell line proliferation on the aggregation and stability of a hyaluronic acid solution (HA)/PLGA microparticles dispersed in the culture system

S. Locarno
Primo
;
A. Galli
Secondo
;
S. Argentiere;M. Galgano;C. Lenardi
Penultimo
;
C. Perego
Ultimo
2022

Abstract

Increasing efforts have been focused on development of novel therapeutic approaches based on a carrier mixed with polymeric microparticles (MPs) for promoting bioactive factors delivery. Polymers as poly (lactide-co-glycolide) are the most widely used due to their tunable physico-chemical properties and biomimetic character. Here, PLGA-MPs of different surface charges were dispersed in hyaluronic acid and their impact on the viability of four cell lines was studied. Our data reveal that the most evident effect is the influence of the cell line proliferation-rate on PLGA-MPs stability and aggregation, highlighting the crucial role of the biological context in affecting microparticles clustering and toxicity.
Cell proliferation; cytotoxicity; hyaluronic acid; microparticle aggregation; PLGA microparticles;
Settore BIO/09 - Fisiologia
RL_DG-UNI16CLENA_01 - Cells Therapy COntrolled RElease Carrier (Cells Therapy CORE Carrier): Carrier a rilascio controllato per terapia cellulare - LENARDI, CRISTINA - RL_DG-UNI - Bandi DG Università, ricerca e open innovation - 2016
14-lug-2021
https://www.tandfonline.com/doi/abs/10.1080/00914037.2021.1941953?tab=permissions&scroll=top
Article (author)
File in questo prodotto:
File Dimensione Formato  
58 2021particles Track_GPOM1941953_AU.pdf

embargo fino al 14/07/2022

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 1.02 MB
Formato Adobe PDF
1.02 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/890324
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact