Esters of sn-glycero-3-phosphoric acid (GPAE) are derivatives of glycerophospholipids in which both the fatty acid chains in sn-1 and sn-2 positions are removed. Phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and phosphatidylserine (PS) are the most abundant glycerophospholipids in Nature. Their deacylated derivatives find application in many industrial sectors; for example, sn-glycero-3-phosphocholine (GPC) is useful as a cognitive enhancer and as a food ingredient, whereas sn-glycero-3-phosphoinositol (GPI) acts as a natural anti-inflammatory agent. This minireview covers the state-of-the-art of chemical and biocatalytic methods for the obtainment of these lipid-derived components.

Chemical and Enzymatic Approaches to Esters of sn-Glycero-3-Phosphoric Acid / R. Semproli, M.S. Robescu, M. Cambo, K. Mema, T. Bavaro, M. Rabuffetti, D. Ubiali, G. Speranza. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2021:29(2021 Aug 06), pp. 4027-4037. [10.1002/ejoc.202100235]

Chemical and Enzymatic Approaches to Esters of sn-Glycero-3-Phosphoric Acid

M. Rabuffetti;G. Speranza
Ultimo
2021

Abstract

Esters of sn-glycero-3-phosphoric acid (GPAE) are derivatives of glycerophospholipids in which both the fatty acid chains in sn-1 and sn-2 positions are removed. Phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and phosphatidylserine (PS) are the most abundant glycerophospholipids in Nature. Their deacylated derivatives find application in many industrial sectors; for example, sn-glycero-3-phosphocholine (GPC) is useful as a cognitive enhancer and as a food ingredient, whereas sn-glycero-3-phosphoinositol (GPI) acts as a natural anti-inflammatory agent. This minireview covers the state-of-the-art of chemical and biocatalytic methods for the obtainment of these lipid-derived components.
Enzyme catalysis; Esters; Phospholipids; Phosphoric acids; Synthetic methods
Settore CHIM/06 - Chimica Organica
CAR_RIC18GSPER_01 - Biocatalysis for oils and fats in cosmetics (BioCosm) - SPERANZA, GIOVANNA - CAR_RIC - Bandi Fondazione Cariplo - 2018
8-apr-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/879592
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