Aims: The association between hyperglycemia at hospital admission and relevant short- and long-term outcomes in elderly population is known. We assessed the effects on mortality of hyperglycemia, disability, and multimorbidity at admission in internal medicine ward in patients aged ≥ 65 years. Methods: Data were collected from an active register of 102 internal medicine and geriatric wards in Italy (RePoSi project). Patients were recruited during four index weeks of a year. Socio-demographic data, reason for hospitalization, diagnoses, treatment, severity and comorbidity indexes (Cumulative Illness rating Scale CIRS-SI and CIRS-CI), renal function, functional (Barthel Index), and cognitive status (Short Blessed Test) and mood disorders (Geriatric Depression Scale) were recorded. Mortality rates were assessed in hospital 3 and 12 months after discharge. Results: Of the 4714 elderly patients hospitalized, 361 had a glycemia level ≥ 250 mg/dL at admission. Compared to subjects with lower glycemia level, patients with glycemia ≥ 250 mg/dL showed higher rates of male sex, smoke and class III obesity. These patients had a significantly lower Barthel Index (p = 0.0249), higher CIRS-SI and CIRS-CI scores (p = 0.0025 and p = 0.0013, respectively), and took more drugs. In-hospital mortality rate was 9.2% and 5.1% in subjects with glycemia ≥ 250 and < 250 mg/dL, respectively (p = 0.0010). Regression analysis showed a strong association between in-hospital death and glycemia ≥ 250 mg/dL (OR 2.07; [95% CI 1.34–3.19]), Barthel Index ≤ 40 (3.28[2.44–4.42]), CIRS-SI (1.87[1.27–2.77]), and male sex (1.54[1.16–2.03]). Conclusions: The stronger predictors of in-hospital mortality for older patients admitted in general wards were glycemia level ≥ 250 mg/dL, Barthel Index ≤ 40, CIRS-SI, and male sex.

Hyperglycemia at admission, comorbidities, and in-hospital mortality in elderly patients hospitalized in internal medicine wards : data from the RePoSI Registry / S. Corrao, A. Nobili, G. Natoli, P.M. Mannucci, F. Perticone, A. Pietrangelo, C. Argano, G. Licata, F. Violi, G.R. Corazza, A. Marengoni, F. Salerno, M. Cesari, M. Tettamanti, L. Pasina, C. Franchi, L. Cortesi, G. Miglio, L. Cortesi, I. Ardoino, A. Novella, D. Prisco, E. Silvestri, G. Emmi, A. Bettiol, C. Caterina, G. Biolo, M. Zanetti, M. Guadagni, M. Zaccari, M. Chiuch, M. Zaccari, M. Vanoli, G. Grignani, E.A. Pulixi, M. Bernardi, S.L. Bassi, L. Santi, G. Zaccherini, G. Lupattelli, E. Mannarino, V. Bianconi, F. Paciullo, R. Alcidi, R. Nuti, R. Valenti, M. Ruvio, S. Cappelli, A. Palazzuoli, D. Girelli, F. Busti, G. Marchi, M. Barbagallo, L. Dominguez, F. Cocita, V. Beneduce, L. Plances, S. Mularo, M. Raspanti, M. Zoli, I. Lazzari, M. Brunori, E. Fabbri, D. Magalotti, R. Arno, F.L. Pasini, P.L. Capecchi, G. Palasciano, M.E. Modeo, C. Di Gennaro, M.D. Cappellini, D. Maira, V. Di Stefano, G. Fabio, S. Seghezzi, M. Mancarella, M.M. De Amicis, G. De Luca, N. Scaramellini, P.D. Rossi, S. Damanti, M. Clerici, F. Conti, G. Bonini, B.B. Ottolini, A. Di Sabatino, E. Miceli, M.V. Lenti, M. Pisati, C.C. Dominioni, G. Murialdo, A. Marra, F. Cattaneo, R. Pontremoli, V. Beccati, G. Nobili, M.B. Secchi, D. Ghelfi, L. Anastasio, L. Sofia, M. Carbone, F. Cipollone, M.T. Guagnano, E. Valeriani, I. Rossi, G. Mancuso, D. Calipari, M. Bartone, G. Delitala, M. Berria, C. Pes, A. Delitala, M. Muscaritoli, A. Molfino, E. Petrillo, G. Zuccala, G. D'Aurizio, G. Romanelli, A. Zucchelli, F. Manzoni, A. Volpini, A. Picardi, U.V. Gentilucci, P. Gallo, C. Dell'Unto, G. Annoni, M. Corsi, G. Bellelli, S. Zazzetta, P. Mazzola, H. Szabo, A. Bonfanti, F. Arturi, E. Succurro, M. Rubino, B. Tassone, G. Sesti, M.G. Serra, M.A. Bleve, L. Gasbarrone, M.R. Sajeva, A. Brucato, S. Ghidoni, F. Fabris, I. Bertozzi, G. Bogoni, M.V. Rabuini, E. Cosi, P. Scarinzi, A. Amabile, E. Omenetto, T. Prandini, R. Manfredini, F. Fabbian, B. Boari, A. De Giorgi, R. Tiseo, R. De Giorgio, G. Paolisso, M.R. Rizzo, C. Borghi, E. Strocchi, E. Ianniello, M. Soldati, C. Sabba, F.S. Vella, P. Suppressa, A. Schilardi, F. Loparco, G.M. De Vincenzo, A. Comitangelo, E. Amoruso, L. Fenoglio, A. Falcetta, C. Bracco, A.L.F.S. Fargion, S. Tiraboschi, A. Cespiati, G. Oberti, G. Sigon, F. Peyvandi, R. Rossio, B. Ferrari, G. Colombo, P. Agosti, V. Monzani, V. Savojardo, C. Folli, G. Ceriani, F. Salerno, G. Pallini, F. Dallegri, L. Ottonello, L. Liberale, L. Caserza, K. Salam, N.L. Liberato, T. Tognin, G.B. Bianchi, S. Giaquinto, F. Purrello, A. Di Pino, S. Piro, R. Rozzini, L. Falanga, E. Spazzini, C. Ferrandina, G. Montrucchio, P. Petitti, P. Peasso, E. Favale, C. Poletto, R. Salmi, P. Gaudenzi, L. Perri, R. Landolfi, M. Montalto, A. Mirijello, L. Guasti, L. Castiglioni, A. Maresca, A. Squizzato, L. Campiotti, A. Grossi, M. Bertolotti, C. Mussi, G. Lancellotti, M.V. Libbra, G. Dondi, E. Pellegrini, L. Carulli, M. Galassi, Y. Grassi, M. Perticone, R. Battaglia, M. Filice, R. Maio, V. Stanghellini, E. Ruggeri, S. del Vecchio, A. Salvi, R. Leonardi, G. Damiani, W. Capeci, A. Gabrielli, M. Mattioli, G.P. Martino, L. Biondi, P. Pettinari, R. Ghio, A.D. Col, S. Minisola, L. Colangelo, M. Cilli, G. Labbadia, A. Afeltra, B. Marigliano, M.E. Pipita, P. Castellino, L. Zanoli, S. Pignataro, A. Gennaro, J. Blanco, V. Saracco, M. Fogliati, C. Bussolino, F. Mete, M. Gino, A. Cittadini, C. Vigorito, M. Arcopinto, A. Salzano, E. Bobbio, A.M. Marra, D. Sirico, G. Moreo, F. Gasparini, S. Prolo, G. Pina, A. Ballestrero, F. Ferrando, S. Berra, S. Dassi, M.C. Nava, B. Graziella, S. Baldassarre, S. Fragapani, G. Gruden, G. Galanti, G. Mascherini, C. Petri, L. Stefani, M. Girino, V. Piccinelli, F. Nasso, V. Gioffre, M. Pasquale, G. Scattolin, S. Martinelli, M. Turrin, L. Sechi, C. Catena, G. Colussi, N. Passariello, L. Rinaldi, F. Berti, G. Famularo, P. Tarsitani, R. Castello, M. Pasino, G.P. Ceda, M.G. Maggio, S. Morganti, A. Artoni, S. Del Giacco, D. Firinu, F. Losa, G. Paoletti, G. Costanzo, G. Montalto, A. Licata, V. Malerba, F.A. Montalto, A. Lasco, G. Basile, A. Catalano, L. Malatino, B. Stancanelli, V. Terranova, S. Di Marca, R. Di Quattro, L. La Malfa, R. Caruso, P. Mecocci, C. Ruggiero, V. Boccardi, T. Meschi, F. Lauretani, A. Ticinesi, A. Nouvenne, P. Minuz, L. Fondrieschi, M. Pirisi, G.P. Fra, D. Sola, M. Porta, P. Riva, R. Quadri, E. Larovere, M. Novelli, G. Scanzi, C. Mengoli, S. Provini, L. Ricevuti, E. Simeone, R. Scurti, F. Tolloso, R. Tarquini, A. Valoriani, S. Dolenti, G. Vannini, A. Tedeschi, L. Trotta, R. Volpi, P. Bocchi, A. Vignali, S. Harari, C. Lonati, M. Cattaneo, F. Napoli. - In: ACTA DIABETOLOGICA. - ISSN 0940-5429. - 58:9(2021 Sep), pp. 1225-1236. [10.1007/s00592-021-01716-8]

Hyperglycemia at admission, comorbidities, and in-hospital mortality in elderly patients hospitalized in internal medicine wards : data from the RePoSI Registry

A. Nobili;P.M. Mannucci;G. Licata;M. Cesari;I. Ardoino;E.A. Pulixi;E. Fabbri;M.D. Cappellini;D. Maira;V. Di Stefano;G. Fabio;N. Scaramellini;S. Damanti;M.V. Lenti;M. Pisati;P. Gallo;G. Annoni;A. Brucato;S. Tiraboschi;A. Cespiati;G. Oberti;G. Sigon;F. Peyvandi;R. Rossio;P. Agosti;V. Monzani;V. Savojardo;G. Pallini;R. Maio;E. Ruggeri;G. Moreo;F. Gasparini;S. Prolo;S. Berra;M.C. Nava;V. Piccinelli;S. Morganti;A. Artoni;G. Montalto;P. Riva;G. Vannini;S. Harari;F. Napoli
2021

Abstract

Aims: The association between hyperglycemia at hospital admission and relevant short- and long-term outcomes in elderly population is known. We assessed the effects on mortality of hyperglycemia, disability, and multimorbidity at admission in internal medicine ward in patients aged ≥ 65 years. Methods: Data were collected from an active register of 102 internal medicine and geriatric wards in Italy (RePoSi project). Patients were recruited during four index weeks of a year. Socio-demographic data, reason for hospitalization, diagnoses, treatment, severity and comorbidity indexes (Cumulative Illness rating Scale CIRS-SI and CIRS-CI), renal function, functional (Barthel Index), and cognitive status (Short Blessed Test) and mood disorders (Geriatric Depression Scale) were recorded. Mortality rates were assessed in hospital 3 and 12 months after discharge. Results: Of the 4714 elderly patients hospitalized, 361 had a glycemia level ≥ 250 mg/dL at admission. Compared to subjects with lower glycemia level, patients with glycemia ≥ 250 mg/dL showed higher rates of male sex, smoke and class III obesity. These patients had a significantly lower Barthel Index (p = 0.0249), higher CIRS-SI and CIRS-CI scores (p = 0.0025 and p = 0.0013, respectively), and took more drugs. In-hospital mortality rate was 9.2% and 5.1% in subjects with glycemia ≥ 250 and < 250 mg/dL, respectively (p = 0.0010). Regression analysis showed a strong association between in-hospital death and glycemia ≥ 250 mg/dL (OR 2.07; [95% CI 1.34–3.19]), Barthel Index ≤ 40 (3.28[2.44–4.42]), CIRS-SI (1.87[1.27–2.77]), and male sex (1.54[1.16–2.03]). Conclusions: The stronger predictors of in-hospital mortality for older patients admitted in general wards were glycemia level ≥ 250 mg/dL, Barthel Index ≤ 40, CIRS-SI, and male sex.
Comorbidity; Diabetes; Disability; Elderly; Hyperglycemia; Mortality
Settore MED/09 - Medicina Interna
Settore MEDS-05/A - Medicina interna
set-2021
22-apr-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/854596
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