Liposomes are amphipathic lipidic supramolecular aggregates that are able to encapsulate and carry molecules of both hydrophilic and hydrophobic nature. They have been widely used as in vivo drug delivery systems for some time because they offer features such as synthetic flexibility, biodegradability, biocompatibility, low immunogenicity, and negligible toxicity. In recent years, the chemical modification of liposomes has paved the way to the development of smart liposome-based drug delivery systems, which are characterized by even more tunable and disease-directed features. In this review, we highlight the different types of chemical modification introduced to date, with a particular focus on internal stimuli-responsive liposomes and prodrug activation.

Stimulus-responsive liposomes for biomedical applications / A. Antoniou, S. Giofre, P. Seneci, D. Passarella, S. Pellegrino. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - (2021 May 29). [Epub ahead of print] [10.1016/j.drudis.2021.05.010]

Stimulus-responsive liposomes for biomedical applications

A. Antoniou
Co-primo
;
S. Giofre
Co-primo
;
P. Seneci;D. Passarella;S. Pellegrino
Ultimo
2021-05-29

Abstract

Liposomes are amphipathic lipidic supramolecular aggregates that are able to encapsulate and carry molecules of both hydrophilic and hydrophobic nature. They have been widely used as in vivo drug delivery systems for some time because they offer features such as synthetic flexibility, biodegradability, biocompatibility, low immunogenicity, and negligible toxicity. In recent years, the chemical modification of liposomes has paved the way to the development of smart liposome-based drug delivery systems, which are characterized by even more tunable and disease-directed features. In this review, we highlight the different types of chemical modification introduced to date, with a particular focus on internal stimuli-responsive liposomes and prodrug activation.
Active targeting; Cancer therapy; Enzyme-responsive liposomes; Hypoxia-responsive liposomes; Internal stimuli; Liposomes; Nanocarriers; pH-responsive liposomes; Redox-responsive liposomes; Self-assembly; Targeted drug delivery
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/852763
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