The chemical structure of oligonucleotide analogues dictates the conformation of oligonucleotide analogue oligomers, their ability to hybridize complementary DNA and RNA, their stability to degradation and their pharmacokinetic properties. In a study aimed at investigating new analogues featuring a neutral backbone, we explored the ability of oligomers containing a morpholino-peptide backbone to bind oligonucleotides. Circular Dichroism studies revealed the ability of our oligomers to interact with DNA, molecular modelling studies revealed the interaction responsible for complex stabilization.

Morpholino-based peptide oligomers: Synthesis and DNA binding properties / A. Contini, E. Erba, V. Bondavalli, A. Barbiroli, M.L. Gelmi, A. Romanelli. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - 549(2021 Apr 16), pp. 8-13. [10.1016/j.bbrc.2021.02.087]

Morpholino-based peptide oligomers: Synthesis and DNA binding properties

A. Contini
Primo
;
E. Erba
Secondo
;
A. Barbiroli;M.L. Gelmi
Penultimo
;
A. Romanelli
Ultimo
2021

Abstract

The chemical structure of oligonucleotide analogues dictates the conformation of oligonucleotide analogue oligomers, their ability to hybridize complementary DNA and RNA, their stability to degradation and their pharmacokinetic properties. In a study aimed at investigating new analogues featuring a neutral backbone, we explored the ability of oligomers containing a morpholino-peptide backbone to bind oligonucleotides. Circular Dichroism studies revealed the ability of our oligomers to interact with DNA, molecular modelling studies revealed the interaction responsible for complex stabilization.
Circular dichroism; DNA; Molecular modelling; Morpholino; Peptide
Settore CHIM/03 - Chimica Generale e Inorganica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/830698
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